Clinical trial Recruiting at 1 site Interventional Ages 40 and up

Computerized alerts to prevent blood clots in hospitalized patients

Official title: Randomized Controlled Trial of Computerized Decision Support for Prevention of Venous Thromboembolism in Hospitalized Medical Patients Across the Continuum of Care (DC-eALERT)

Run by Brigham and Women's Hospital · NCT03728166 · Data updated 2026-11-12

This study is testing if using computer alerts can help doctors give blood clot prevention medication to hospitalized patients who are at risk.

Quick facts

Study typeInterventional
Ages40 Years and up
SexAll
Enrollment400 (estimated)
SponsorBrigham and Women's Hospital
Academic / other
Locations1 site (Boston, Massachusetts)
StatusRecruiting
StartedFebruary 1, 2019
Main results expectedDecember 31, 2022
Study endsDecember 30, 2026
Registry record updatedSeptember 29, 2026
Trial IDNCT03728166 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are hospitalized patients aged 40 and older with acute medical illnesses who are at risk for VTE and not currently prescribed thromboprophylaxis.

Probably not a fit

Patients who are already prescribed thromboprophylaxis at hospital discharge will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of an electronic alert-based decision support tool in increasing the prescription of extended-duration thromboprophylaxis for hospitalized medical patients at risk of venous thromboembolism (VTE). The study will involve 400 patients who are 40 years or older and hospitalized for acute medical illnesses, focusing on those who are not currently prescribed thromboprophylaxis. Participants will be randomly assigned to receive either the computerized alerts or standard care without alerts. The goal is to improve patient outcomes by ensuring high-risk patients receive appropriate preventive treatment before discharge.

Why it matters

Potential benefit: If successful, this approach could significantly reduce the incidence of VTE in hospitalized patients, improving patient safety and outcomes.

How similar studies have gone: Previous studies have shown success with computerized decision support tools in improving clinical outcomes, suggesting potential for this approach.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

-≥40 years of age, are hospitalized for acute medical illness (heart failure, respiratory failure, infectious disease, rheumatic disease, or ischemic stroke), have reduced mobility, are not prescribed thromboprophylaxis at hospital discharge, and have one additional risk factor for VTE:

* Age ≥60
* Prior VTE OR
* History of cancer

Exclusion Criteria:

\- Prescribed thromboprophylaxis at hospital discharge

Where it's running

  • Brigham and Women's Hospital
    Boston, Massachusetts, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.