Computerized alerts to prevent blood clots in hospitalized patients
Official title: Randomized Controlled Trial of Computerized Decision Support for Prevention of Venous Thromboembolism in Hospitalized Medical Patients Across the Continuum of Care (DC-eALERT)
Run by Brigham and Women's Hospital · NCT03728166 · Data updated 2026-11-12
This study is testing if using computer alerts can help doctors give blood clot prevention medication to hospitalized patients who are at risk.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 40 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | February 1, 2019 |
| Main results expected | December 31, 2022 |
| Study ends | December 30, 2026 |
| Registry record updated | September 29, 2026 |
| Trial ID | NCT03728166 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are hospitalized patients aged 40 and older with acute medical illnesses who are at risk for VTE and not currently prescribed thromboprophylaxis.
✕Probably not a fit
Patients who are already prescribed thromboprophylaxis at hospital discharge will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to evaluate the effectiveness of an electronic alert-based decision support tool in increasing the prescription of extended-duration thromboprophylaxis for hospitalized medical patients at risk of venous thromboembolism (VTE). The study will involve 400 patients who are 40 years or older and hospitalized for acute medical illnesses, focusing on those who are not currently prescribed thromboprophylaxis. Participants will be randomly assigned to receive either the computerized alerts or standard care without alerts. The goal is to improve patient outcomes by ensuring high-risk patients receive appropriate preventive treatment before discharge.
Why it matters
Potential benefit: If successful, this approach could significantly reduce the incidence of VTE in hospitalized patients, improving patient safety and outcomes.
How similar studies have gone: Previous studies have shown success with computerized decision support tools in improving clinical outcomes, suggesting potential for this approach.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: -≥40 years of age, are hospitalized for acute medical illness (heart failure, respiratory failure, infectious disease, rheumatic disease, or ischemic stroke), have reduced mobility, are not prescribed thromboprophylaxis at hospital discharge, and have one additional risk factor for VTE: * Age ≥60 * Prior VTE OR * History of cancer Exclusion Criteria: \- Prescribed thromboprophylaxis at hospital discharge
Where it's running
-
Brigham and Women's Hospital
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Gregory Piazza, MD, MS — Bwh
- Study coordinator: Gregory Piazza, MD, MS
- Email: gpiazza@bwh.harvard.edu
- Phone: 6177326984
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.