Dietary composition effects on appetite and energy regulation
Official title: Do Dietary Patterns Influence Your Weight Management and Circadian Rhythms?
Run by Brigham and Women's Hospital · NCT05800990 · Data updated 2026-11-12
This study is testing how different types of diets affect hunger and energy use to help people manage obesity better.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 45 Years |
| Sex | All |
| Enrollment | 24 (estimated) |
| Sponsor | Brigham and Women's Hospital Academic / other |
| Locations | 1 site (Boston, Massachusetts) |
| Status | Recruiting |
| Started | November 8, 2024 |
| Main results expected | August 31, 2027 |
| Study ends | August 31, 2027 |
| Registry record updated | October 20, 2026 |
| Trial ID | NCT05800990 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are adults aged 18-45 with a BMI between 18.5 and 29.9 who do not have any acute or chronic medical conditions.
✕Probably not a fit
Patients with significant medical conditions, food allergies, or those on specific diets may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial aims to investigate how different dietary compositions influence food intake rhythms, appetite regulation, and energy expenditure. Participants will undergo two field-based dietary interventions and two inpatient stays, during which they will consume standard meals and provide various biological samples. The study seeks to understand the connection between diet and the circadian system to develop evidence-based dietary interventions for obesity management.
Why it matters
Potential benefit: If successful, this study could lead to effective dietary strategies for weight management and obesity prevention.
How similar studies have gone: Previous studies have shown promising results in understanding the relationship between diet and circadian rhythms, but this specific approach is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * 18-45 yr old * BMI 18.5-29.9 * No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.) * Without medication use (except oral contraceptives) Exclusion Criteria: * Currently smoking/vaping or 5 or more years of smoking/vaping * History of drug or alcohol dependency * History of psychiatric illness or disorder * People with food allergies/intolerances or following specific diets
Where it's running
-
Brigham and Women's Hospital
Boston, Massachusetts, United States Recruiting
Study contacts
- Principal investigator: Frank AJL Scheer, PhD — Brigham and Women's Hospital
- Study coordinator: Frank A.J.L. Scheer, PhD
- Email: FSCHEER@BWH.HARVARD.EDU
- Phone: 617-732-7014
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
High-protein, high-fiber pre-fast meal effects on fullness and blood sugar during fasting
This test sees if eating a high-protein, high-fiber meal before a fasting period helps healthy adults feel fuller and keep blood sugar steadier than a low-protein, low-fiber meal.
-
A dietary and behavioral intervention to improve health and sustainability
This study is testing a new lifestyle program that combines diet tips and support to see if it can help people improve their health and the environment better than regular diet advice alone.
-
Prenatal and postnatal strategies to improve breastfeeding for women with excess weight
This project will test whether prenatal hand expression of colostrum, a postnatal meal plan, and extra lactation support help pregnant women with overweight or obesity breastfeed more successfully.
-
Home-delivered DASH groceries for Southeastern US residents to lower blood pressure
This project will test whether adults with high blood pressure in Florida, Georgia, and Tennessee who receive dietitian‑assisted, home‑delivered DASH groceries for 4 weeks have larger blood pressure drops than those given a shopping stipend and a DASH brochure.
-
Patiromer to allow more flexible potassium diets and improve quality of life for people on chronic dialysis
This trial will test whether giving patiromer to people on chronic hemodialysis lets them relax potassium restrictions in their diet without raising their risk of high blood potassium.
-
Effects of CONTRAVE on weight loss and behavior in adults with obesity
This study is testing if the weight-loss drug CONTRAVE can help adults with obesity lose weight and manage their appetite better when combined with a diet.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.