Condition

Pain, Postoperative clinical trials and research

• 95Clinical trials
• 24Countries

Newest Pain, Postoperative clinical trials

All recruiting trials (95)

• Low-Volume PENG Block With Dexamethasone After Hip Replacement

  This trial tests whether a smaller PENG block with dexamethasone provides similar pain relief but preserves quadriceps strength after hip replacement, compared with the standard-volume PENG block.

  Recruiting Phase 4 Ain Shams University · Cairo, Cairo Governorate · NCT07855341

• Analgesia after open inguinal hernia repair using intrathecal morphine or a transversalis fascia plane block

  This trial tests whether intrathecal morphine or a ultrasound-guided transversalis fascia plane block can provide better pain relief after open inguinal hernia repair in adults.

  Recruiting Atatürk Chest Diseases and Chest Surgery Training and Research Hospital · Yenimahalle, Ankara · NCT07826741

• Single-level vs two-level erector spinae plane block for breast surgery

  This study tests whether a single-level ESPB provides similar pain relief to a two-level ESPB for adults undergoing breast surgery.

  Recruiting Atatürk Chest Diseases and Chest Surgery Training and Research Hospital · Yenimahalle, Ankara · NCT07747623

• Transverse vs Longitudinal Serratus Anterior Plane Block for Breast Surgery

  This trial tests whether a longitudinal ultrasound view for serratus anterior plane block provides better pain relief after breast surgery than the standard transverse view.

  Recruiting Ankara Etlik City Hospital · Ankara, Yenimahalle\Ankara · NCT07739277

• iPAWS: Helping teens manage pain and risky behaviors after wisdom tooth removal

  This program tests a short online intervention to help teens and their parents handle post-surgical pain and reduce risky behaviors after wisdom tooth extraction.

  Recruiting Brown University · Providence, Rhode Island · NCT07731295

• Single-shot nerve block with IV dexamethasone for rebound pain after shoulder surgery

  This trial tests whether giving a one-time shoulder nerve block plus an IV dexamethasone dose can prevent rebound pain after shoulder surgery.

  Recruiting Phase 4 Seoul National University Hospital · Seoul, Jongno-gu · NCT07699744

• VR After Hip Replacement: See if Virtual Reality Helps Pain and Comfort

  This study tests whether virtual reality can help adults recover after total hip replacement by reducing pain and anxiety and improving comfort.

  Recruiting Adiyaman University · Malatya · NCT07689461

• Liposomal vs Standard Bupivacaine for Post-Rhinoplasty Pain

  This study tests whether liposomal bupivacaine provides better pain control after rhinoplasty than standard bupivacaine.

  Recruiting Phase 2 Washington University School of Medicine · St Louis, Missouri · NCT07689162

• Liposomal Bupivacaine Plus Plain Bupivacaine vs Dexamethasone Plus Plain Bupivacaine for High-Risk Pain After Supraclavicular Brachial Plexus Block

  This trial tests whether liposomal bupivacaine with plain bupivacaine can better control postoperative pain after distal radial fracture surgery in patients at high risk of severe pain, compared with dexamethasone plus plain bupivacaine.

  Recruiting Phase 3 The University of Hong Kong · Hong Kong · NCT07665762

• Rhomboid Intercostal Block vs Serratus Posterior Superior Intercostal Plane Block for VATS Pain

  This study tests two regional anesthesia techniques to see which better reduces postoperative pain after video-assisted thoracic surgery in adults undergoing thoracic procedures.

  Recruiting Ankara City Hospital Bilkent · Çankaya, Ankara · NCT07650877

• Dexa vs Dexmedetomidine with Bupivacaine in TAP Block for Laparotomy Analgesia

  This study tests whether adding dexamethasone or dexmedetomidine to bupivacaine in a TAP block improves postoperative pain control after laparotomy.

  Recruiting Phase 2/3 Sahiwal medical college sahiwal · Sahiwal, Punjab Province · NCT07590752

• Using pectointercostal and other fascial plane nerve blocks to improve recovery after open‑heart (sternotomy) surgery

  This study will test whether adding ultrasound‑guided pectointercostal and related fascial plane nerve blocks to standard care speeds recovery and reduces pain for adults having elective open‑heart surgery through a median sternotomy.

  Recruiting Ordu University · Ordu, Altinordu · NCT07557108

• Bupivacaine plus lidocaine versus bupivacaine alone for ultrasound-guided popliteal sciatic nerve block

  This trial will test whether adding lidocaine to bupivacaine gives faster numbness and longer-lasting pain relief for adults having below-knee (foot or ankle) surgery with an ultrasound-guided popliteal sciatic nerve block.

  Recruiting Ataturk University · Erzurum · NCT07550348

• Methadone for post-op spine surgery pain control

  This trial tests whether giving methadone around the time of spine surgery helps with pain control and lowers opioid needs after surgery for adults.

  Recruiting Phase 4 University of Kentucky · Lexington, Kentucky · NCT07517679

• Single versus double drains after modified radical mastectomy with quilting stitches

  This trial will test whether using one drain instead of two, together with quilting stitches, reduces fluid buildup, pain, and infections after modified radical mastectomy for adults with breast cancer.

  Recruiting Sindh Institute of Urology and Transplantation · Karachi, Sindh · NCT07512141

• Low vs. standard volume EXORA block for pain control in laparoscopic gallbladder surgery

  This trial tests whether a smaller amount of local anesthetic given as a bilateral EXORA block provides pain relief after laparoscopic cholecystectomy.

  Recruiting Fayoum University Hospital · El Fayoum Qesm, Faiyum Governorate · NCT07507799

• Tegileridine for faster bowel recovery after abdominal surgery

  This trial tests if tegileridine, given after abdominal surgery, helps the gut start working sooner compared with morphine while both are used with a patient-controlled pump.

  Recruiting at 3 sites Phase 4 Xiangya Hospital of Central South University · Guangzhou, Guangdong and 2 other locations · NCT07412223

• Comparing BiFeS and iPACK nerve blocks for pain after knee replacement

  This trial will test if adding the BiFeS nerve block to an adductor canal block controls pain and reduces opioid use more than adding the iPACK block in people having total knee replacement.

  Recruiting Amasya University · Amasya · NCT07360392

• Erector spinae versus quadro-iliac nerve blocks for pain after lumbar instrumentation

  This study will test whether an erector spinae plane block or a quadro-iliac plane block gives better pain relief after elective lumbar instrumentation surgery in adults.

  Recruiting Bursa City Hospital · Bursa · NCT07354581

• Dexamethasone Palmitate for Postoperative Pain: A New Lipid-Formulated Option

  This study tests whether preoperative intravenous dexamethasone palmitate helps reduce moderate-to-severe postoperative pain better than conventional dexamethasone.

  Recruiting Beijing Tiantan Hospital · Beijing, China · NCT07341854

• Adding dexmedetomidine to bupivacaine for pain relief after abdominal surgery

  This trial will try adding dexmedetomidine to bupivacaine in a TAP block to see if adults having elective abdominal surgery get better pain relief and need less extra pain medicine than with bupivacaine alone.

  Recruiting Sheikh Zayed Medical College · Rahim Yar Khan, Punjab Province · NCT07285083

• PENG block plus local infiltration analgesia for anterior-approach hip replacement

  This test sees if a motor-sparing PENG block combined with local infiltration around the hip controls pain as well as spinal anesthesia for adults having anterior‑approach hip replacement.

  Recruiting ASST Gaetano Pini-CTO · Milan · NCT07239817

• Baduanjin Exercises After Total Knee Replacement

  This trial will test whether doing Baduanjin exercises after total knee replacement can reduce pain and improve comfort and recovery in adult patients.

  Recruiting University of Yalova · Yalova · NCT07109557

• Autonomic Nerve Blockade to Reduce Pain and Nausea After Bariatric Surgery

  This study tests whether an autonomic nerve block given during bariatric surgery can lessen pain and nausea and decrease the need for anti-nausea and pain medicines in the first 72 hours after sleeve gastrectomy or gastric bypass.

  Recruiting Endeavor Health · Evanston, Illinois · NCT07104825

• Sacral erector spinae plane block versus caudal epidural block for pain after hypospadias repair in young boys

  This trial will see if a sacral erector spinae plane block or a caudal epidural block gives better pain relief for boys aged 1–5 after hypospadias repair.

  Recruiting Tanta University · Tanta, El-Gharbia Govenorate · NCT07099560

• Clonidine added to ultrasound-guided rectus sheath block for outpatient umbilical hernia repair

  This trial will test whether adding clonidine to an ultrasound-guided rectus sheath block reduces pain for adults having outpatient umbilical hernia repair.

  Recruiting Phase 2/3 Universidade Federal do Rio de Janeiro · Rio de Janeiro, Rio de Janeiro · NCT07062497

• Aloe vera gel versus paraffin tulle dressings for donor-site pain after split-thickness skin grafts

  This trial tests whether Aloe vera gel dressings reduce pain more than paraffin tulle dressings for adults (18–60) after split-thickness skin graft donor-site wounds.

  Recruiting King Edward Medical University · Lahore, Punjab Province · NCT07057557

• Perioperative IV nimodipine for people undergoing open colectomy for bowel cancer

  This trial tests whether giving intravenous nimodipine around the time of open colectomy can reduce opioid use, lower pain, and speed early bowel recovery for people having surgery for bowel cancer.

  Recruiting University of Ioannina · Pátrai, Achaea · NCT07048522

• Robot-assisted radical cystectomy: effects on blood loss, pain, and transfusions

  This trial will test whether robot-assisted bladder removal (radical cystectomy), with or without bladder reconstruction, leads to less blood loss, less postoperative pain, and fewer transfusions for people scheduled for radical cystectomy.

  Recruiting Goethe University · Frankfurt am Main · NCT07008261

• Comparing two methods for pain relief after minimally invasive heart surgery

  This study is testing two different ways to relieve pain after minimally invasive heart surgery to see which one helps patients feel better and use fewer pain medications.

  Recruiting İstanbul Yeni Yüzyıl Üniversitesi · Istanbul · NCT06968065

• Minimally invasive Ennovate® method for cervical pedicle screw placement

  This project tests whether the minimally invasive Ennovate® method for placing cervical pedicle screws is safe and helps adults who need posterior cervical fusion.

  Recruiting at 3 sites Aesculap AG · Aachen and 2 other locations · NCT06960018

• Using buprenorphine for pain relief after ankle fracture surgery

  This study tests if a skin patch with buprenorphine can help manage pain after ankle fracture surgery for patients who haven't used opioids before, while also looking at safety and the risk of addiction.

  Recruiting Phase 4 Washington University School of Medicine · St Louis, Missouri · NCT06949826

• Comparing pain management methods for ACL surgery

  This study is testing whether a new way of managing pain before ACL surgery works better than a traditional method to help patients recover more comfortably.

  Recruiting Ankara University · Ankara · NCT06936995

• Using Virtual Reality to Reduce Pain and Anxiety Before Spine Surgery

  This study tests if using virtual reality can help reduce pain and anxiety for people getting ready for spine surgery compared to those who only get standard care.

  Recruiting Medical University of Lodz · Lodz, Łódź Voivodeship · NCT06917300

• Comparing pain relief methods after knee surgery

  This study is testing which pain relief method, Adductor Canal Block or Genicular Nerve Block, works better for people aged 18-72 after knee surgery.

  Recruiting Başakşehir Çam & Sakura City Hospital · Istanbul · NCT06909851

• Using the Nociception Level Index to guide opioid dosing during combined regional and general anesthesia

  This trial tests whether using a Nociception Level Index (NOL) monitor to guide opioid dosing during combined general and regional anesthesia can reduce opioid use and side effects for adults having elective trauma or orthopedic surgery.

  Recruiting Universitätsklinikum Hamburg-Eppendorf · Hamburg · NCT06905340

• Comparing two nerve block techniques for pain relief after hip surgery

  This study is testing which of two nerve block techniques helps people recover with less pain and fewer opioids after hip surgery.

  Recruiting Başakşehir Çam & Sakura City Hospital · Istanbul, Türki̇ye · NCT06821516

• Low-dose Esketamine for preventing delirium in elderly patients undergoing surgery

  This study is testing if low-dose Esketamine can help prevent confusion after surgery in older adults aged 65 to 90.

  Recruiting at 3 sites Nanfang Hospital, Southern Medical University · Fuzhou, Fujian and 5 other locations · NCT06817239

• Comparing postoperative pain from different neck surgery methods

  This study looks at how much pain people with thyroid cancer feel after different types of neck surgery to see if less invasive methods help reduce discomfort.

  Recruiting Shanghai 6th People's Hospital · Shanghai, Shanghai Municipality · NCT06803732

• Comparing ketamine delivery methods for postoperative pain management in orthopedic surgery

  This study is testing whether giving ketamine through an IV or a patient-controlled pump works better for managing pain after major orthopedic surgery in adults.

  Recruiting Phase 4 Universidad de Antioquia · Medellín, Antioquia · NCT06774274

• Comparing intrathecal morphine and continuous wound infiltration for pain relief after pancreatic surgery

  This study is testing whether a single injection of morphine into the spine can help manage pain better than a continuous pain relief method after pancreatic surgery for adults.

  Recruiting Seoul National University Hospital · Seoul, Seoul · NCT06761989

• Different doses of liposomal bupivacaine for adductor canal block after total knee replacement

  This will test whether different doses of liposomal bupivacaine given in the adductor canal block reduce pain and opioid use after elective total knee replacement in adults.

  Recruiting Phase 3 The University of Hong Kong · Hong Kong, Hong Kong · NCT06740214

• Effects of Quranic Recitation and Classical Music on Pain and Inflammation After Surgery

  This study is testing whether listening to Islamic verse recitation or classical music during surgery can help reduce pain and inflammation after the operation compared to standard care.

  Recruiting Universitas Jenderal Soedirman · Purwokerto, Central Java · NCT06713044

• Comparing two pain relief methods after laparoscopic hernia surgery

  This study is testing two different pain relief methods after laparoscopic hernia surgery to see which one helps patients feel better and need less extra pain medication.

  Recruiting Gaziosmanpasa Research and Education Hospital · Istanbul · NCT06664177

• Investigating reasons for longer hospital stays after lung surgery

  This study looks at why some patients stay in the hospital longer after lung surgery and aims to find ways to improve their recovery.

  Recruiting at 2 sites University Hospital, Ghent · Bruges and 1 other locations · NCT06638645

• Comparing pain control methods after tonsil surgery in children

  This study is testing whether long-lasting pain medicine like methadone works better than short-lasting options like fentanyl and hydromorphone for controlling pain in kids and teens after tonsil surgery.

  Recruiting Phase 4 Duke University · Durham, North Carolina · NCT06576830

• Reducing opioid use after neck surgery with a nerve block

  This study is testing if a special nerve block can help people having neck surgery use less opioids for pain relief compared to standard pain management.

  Recruiting Stony Brook University · Stony Brook, New York · NCT06570577

• Using Exparel to control pain after MPFL reconstruction in kids

  This study sees if adding Exparel to standard local anesthesia reduces post-op pain and opioid pill use in patients aged 13 and older having an isolated MPFL reconstruction.

  Recruiting Phase 2 Texas Scottish Rite Hospital for Children · Frisco, Texas · NCT06559215

• Saddle spinal block with low-dose intrathecal morphine for pain after penile inversion vaginoplasty

  This trial tests whether adding a motor-sparing saddle spinal block with low-dose intrathecal morphine to usual pain care reduces postoperative pain after penile inversion vaginoplasty for transgender women.

  Recruiting Women's College Hospital · Toronto, Ontario · NCT06556121

• Comparing pain relief methods after lumbar fusion surgery

  This study tests whether a new way of giving local anesthesia during lumbar fusion surgery can help patients feel less pain and use fewer opioids compared to the traditional method.

  Recruiting University of Massachusetts, Worcester · Worcester, Massachusetts · NCT06528288

• Using Midazolam to Improve Postoperative Pain Relief for Colorectal Cancer Patients with Anxiety or Sleep Issues

  This study is testing if giving midazolam before surgery can help colorectal cancer patients with anxiety or sleep issues feel less pain and recover faster afterward.

  Recruiting Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT06407518

• Opioid-free anesthesia for breast cancer surgery

  This study tests whether using opioid-free anesthesia during breast cancer surgery can help patients recover better and have fewer side effects compared to traditional anesthesia.

  Recruiting University of Ioannina · Ioannina, Epirus · NCT06404983

• Comparing cryoablation and standard methods for pain control after thoracic surgery

  This study is testing if a new pain relief method called cryoablation works better than standard techniques for people recovering from thoracic surgery.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT06384664

• Evaluating opioid-free pain management before urogynecologic surgeries

  This study is testing if a combination of pain relievers without opioids can help women recover faster after certain bladder surgeries.

  Recruiting Phase 4 Northwell Health · Bay Shore, New York · NCT06379425

• Smart opioid dispenser and app for patients having a one-level lumbar discectomy or laminectomy

  This test tries a locked opioid-dispensing device plus a smartphone app to help adults having a one-level lumbar discectomy or laminectomy who are opioid-naive or occasional users take oxycodone more safely after discharge.

  Recruiting Hospital for Special Surgery, New York · New York, New York · NCT06358040

• Improving pain management after pituitary surgery

  This study is testing whether a special pain relief technique using a nerve block can help people feel less pain after having minimally invasive pituitary surgery.

  Recruiting Phase 4 Hamilton Health Sciences Corporation · Hamilton, Ontario · NCT06353529

• Comparing pain relief from two medications after knee surgery

  This study tests whether mirogabalin or pregabalin works better to relieve pain after knee surgery for people aged 50-85 with osteoarthritis.

  Recruiting Thammasat University Hospital · Khlong Luang, Changwat Pathum Thani · NCT06328062

• Improving pain control after cesarean section with nerve blocks

  This study is testing if a special pain relief method called TAP blocks can help women feel less pain and recover faster after having a cesarean section.

  Recruiting University of Calgary · Calgary, Alberta · NCT06324942

• Optimal timing for TAP blocks in bariatric surgery

  This study is testing whether giving a pain relief shot earlier during bariatric surgery helps obese patients recover faster and use less pain medication.

  Recruiting Phase 2 McMaster University · Hamilton, Ontario · NCT06270147

• Different ways to record pain after surgery.

  This study tests three ways for adults after surgery to record their pain—a handwritten journal, a smartphone app, or a small electronic device—to see which method produces more frequent pain entries.

  Recruiting University of California, San Francisco · San Francisco, California · NCT06206148

• Comparing pain management methods for hip surgery in children with cerebral palsy

  This study is testing whether local anesthetic injections can help manage pain better than traditional epidural anesthesia for children with cerebral palsy after hip surgery.

  Recruiting at 3 sites Phase 4 University of California, Los Angeles · Los Angeles, California and 3 other locations · NCT06189781

• Improving sleep to reduce pain after joint surgery

  This study is testing if helping people with insomnia sleep better before knee or hip surgery can reduce their pain after the operation.

  Recruiting Uppsala University · Uppsala, Uppland · NCT06145516

• Using placebos to manage postoperative pain

  This study is testing if using a special pill or scent along with regular pain medication can help patients after thoracic and spinal surgeries use less opioids and feel better.

  Recruiting Centre de Médecine Intégrative et Complémentaire (CEMIC) · Lausanne, Canton of Vaud · NCT06107595

• Non-invasive pain management after lumbar fusion surgery

  This study is testing if a new non-opioid pain relief method called transcutaneous auricular neurostimulation can help people feel less pain after lumbar fusion surgery.

  Recruiting University of Texas Southwestern Medical Center · Dallas, Texas · NCT06100172

• Evaluating sensation and satisfaction in cancer and transgender mastectomy patients

  This study is testing if advanced surgical techniques can improve sensation and satisfaction for people undergoing gender-affirming mastectomy and breast reconstruction.

  Recruiting at 2 sites Weill Medical College of Cornell University · Boston, Massachusetts and 1 other locations · NCT06094257

• Improving chest tube and pain management after surgery for spontaneous pneumothorax

  This study is testing whether taking out chest tubes right after surgery for a collapsed lung can help patients recover faster and feel less pain compared to keeping them in for several days.

  Recruiting Maxima Medical Center · Veldhoven · NCT06053476

• Improving surgical outcomes for Latinx children

  This study is testing a mobile health program to help Latinx children aged 2-7 feel less anxious and manage pain better before and after their outpatient surgeries.

  Recruiting University of California, Irvine · Orange, California · NCT06020677

• Comparing recovery after different anesthesia techniques in surgery

  This study is testing whether recovery is better after surgery using either intravenous propofol or inhaled anesthesia for different types of surgeries.

  Recruiting at 22 sites Washington University School of Medicine · Little Rock, Arkansas and 23 other locations · NCT05991453

• Effects of Depo-Medrol on Psoas Muscle After Lumbar Spine Surgery

  This study tests if giving a corticosteroid called Depo-Medrol to the psoas muscle after lumbar spine surgery can help reduce thigh pain and improve hip strength compared to patients who don’t receive the injection.

  Recruiting Phase 4 UConn Health · Farmington, Connecticut · NCT05929755

• Comparing mindfulness breathing and biofeedback for pain relief after shoulder surgery

  This study tests whether mindfulness breathing, biofeedback, or pain education can help people who are having shoulder surgery feel less pain and recover better.

  Recruiting Chang Gung Memorial Hospital · Taoyuan · NCT05917262

• Comparing pain and swelling after two types of endodontic microsurgery

  This study is testing whether patients who have endodontic microsurgery feel less pain and swelling after using a traditional method compared to a newer technique.

  Recruiting King Abdullah University Hospital · Irbid · NCT05898035

• Documenting opioid use and pain management after surgery

  This study looks at how opioids are used for pain management after surgery in adults to see how it affects their recovery and quality of life over time.

  Recruiting University of Aberdeen · Zagreb, Vinogradska 29 and 3 other locations · NCT05877157

• Effects of Buprenorphine, Clonidine, and Dexamethasone on Pain Management After Shoulder Surgery

  This study is testing if adding buprenorphine, clonidine, and dexamethasone to a common pain relief method can help people manage pain better after shoulder surgery.

  Recruiting Phase 4 Loyola University · Maywood, Illinois · NCT05824832

• Evaluating the impact of zolpidem on recovery after lumbar spine fusion surgery

  This study is testing if giving a sleep aid called zolpidem to patients having spine surgery can help them recover better and feel less pain.

  Recruiting Phase 4 University of Southern California · Los Angeles, California · NCT05746143

• Comparing pain relief methods after surgery

  This study is testing whether a combination of over-the-counter pain relievers works better and has fewer side effects than low-dose opioids for people recovering from common surgeries.

  Recruiting at 8 sites Phase 4 University of Michigan · Ann Arbor, Michigan and 7 other locations · NCT05722002

• Erector spinae plane block for managing pain after breast cancer surgery

  This study is testing if a special nerve block combined with a medication can help reduce pain and improve recovery for women after breast cancer surgery.

  Recruiting at 2 sites Peking University First Hospital · Beijing, Beijing Municipality and 1 other locations · NCT05494502

• Using cryoablation to improve pain control after rib fracture surgery

  This study is testing if using cryoablation on certain nerves after rib fracture surgery can help patients feel less pain and use fewer pain medications.

  Recruiting Wake Forest University Health Sciences · Winston-Salem, North Carolina · NCT05415384

• Mindfulness for new moms after cesarean to ease pain and mood

  This small, early-phase trial tests a self-guided 8-week mindfulness program delivered on a mobile device to see if it can reduce pain after cesarean delivery and lower postpartum depressive symptoms in new mothers.

  Recruiting University of Illinois at Urbana-Champaign · Champaign, Illinois · NCT05400382

• Using intrathecal morphine to manage pain after lung surgery

  This study is testing if a special type of morphine given directly into the spine can help reduce pain and the need for other pain medications after lung surgery.

  Recruiting Phase 4 Northwestern University · Chicago, Illinois · NCT05351229

• ESP nerve block versus wound infiltration for pain after laminectomy

  This trial will try whether an erector spinae plane (ESP) block or wound infiltration gives better pain relief and reduces opioid use for adults having a one- or two-level laminectomy.

  Recruiting University of Padova · Padova, Veneto · NCT05271331

• Optimizing anesthesia for pediatric Le Fort surgeries

  This study is testing a new anesthesia plan for kids having Le Fort surgeries to see if it helps them feel less pain afterward and recover faster compared to the usual care.

  Recruiting Johns Hopkins University · Baltimore, Maryland · NCT05260320

• Using steroids during lumbar surgery to reduce pain and opioid use

  This study tests if using steroids during back surgery can help reduce pain and the need for opioids in patients recovering from the procedure.

  Recruiting Phase 3 Hospital for Special Surgery, New York · New York, New York · NCT05058287

• Using gabapentin before wisdom teeth removal to reduce pain and opioid use

  This study tests if taking gabapentin before getting your wisdom teeth removed can help manage pain and reduce the need for opioids during recovery.

  Recruiting Phase 4 Loma Linda University · Loma Linda, California · NCT04860141

• Using gabapentin to reduce opioid use in children after thoracic surgery

  This study is testing if gabapentin can help reduce the amount of pain medication kids need after having thoracic surgery.

  Recruiting Phase 2/3 University of California, Davis · Sacramento, California · NCT04724252

• Opioid-free pain management after orthopedic surgery

  This study is testing a new way to manage pain after orthopedic surgery without using opioids to see if it helps patients feel better and reduces the need for painkillers.

  Recruiting at 3 sites Phase 3 Emory University · Atlanta, Georgia and 2 other locations · NCT04659317

• Pectoral nerve block versus local numbing for children getting chest pacemaker or ICD placement

  This test will see if giving a pectoral nerve block before implant surgery helps children need fewer opioids after chest device placement than local numbing alone.

  Recruiting Phase 4 The Hospital for Sick Children · Toronto, Ontario · NCT04577690

• Evaluating pain pathways and nerve regeneration in keratoconus patients after corneal crosslinking

  This study is testing how corneal crosslinking affects pain and nerve healing in people with keratoconus to see how their pain changes over time.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT04439552

• New technology for deep brain stimulation to treat chronic pain

  This study is testing a new type of brain stimulation to see if it can help people with chronic pain that doesn't respond to regular treatments.

  Recruiting University of California, San Francisco · San Francisco, California · NCT04144972

• Infusion of pain relief medication after minimally invasive hysterectomy

  This study is testing if a continuous infusion of pain relief medication can help women feel less pain after having a minimally invasive hysterectomy compared to a placebo.

  Recruiting at 2 sites Phase 4 George Washington University · Washington D.C., District of Columbia and 1 other locations · NCT04130464

• Using pulsed electromagnetic field therapy to reduce post-operative pain after orthopedic surgery

  This study is testing if pulsed electromagnetic field therapy can help reduce pain after shoulder or knee surgery for adults.

  Recruiting Stanford University · Redwood City, California · NCT04109638

• Comparing opioids and non-opioids for pain management after knee surgery

  This study is testing whether non-opioid pain medications can work as well as opioids for people recovering from knee surgery.

  Recruiting Phase 4 Sanford Health · Fargo, North Dakota · NCT03858231

• Opioid-free care for patients undergoing obesity surgery

  This study is testing if an opioid-free way to manage pain can help people recovering from obesity surgery feel better and heal faster compared to using traditional opioid medications.

  Recruiting at 2 sites Göteborg University · Lindesberg, Region Örebro and 1 other locations · NCT03756961

• Comparing liposomal bupivacaine and plain bupivacaine for pain management after thoracoscopic surgery

  This study is testing whether a newer form of bupivacaine can help manage pain after thoracoscopic surgery better and safely compared to the regular version.

  Recruiting Phase 4 Milton S. Hershey Medical Center · Hershey, Pennsylvania · NCT03737292

• Comparing spinal and epidural anesthesia for liver surgery recovery

  This study is testing whether spinal anesthesia can help people recovering from liver surgery feel better and recover faster compared to epidural anesthesia.

  Recruiting University of Manitoba · Winnipeg, Manitoba · NCT03715517

• Comparing continuous and scheduled bolus infusions for post-surgical pain management

  This study is testing whether continuous or scheduled doses of local anesthetic work better for managing pain after surgery in adults who receive nerve blocks.

  Recruiting Phase 4 Stanford University · Stanford, California · NCT03230565

Related topics

Quick answers

How many Pain, Postoperative clinical trials are recruiting right now?

95, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 24 countries. The most sites are in United States (37 trials), Turkey (Türkiye) (15 trials), Canada (7 trials), China (6 trials), Pakistan (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 21, Phase 3: 4, Phase 2: 3, Phase 2/3: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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