Condition

Nerve Block clinical trials and research

• 19Clinical trials
• 7NIH research projects
• 6Countries

Newest Nerve Block clinical trials

All recruiting trials (19)

• Nervous system blocks to ease pain after lung cancer surgery

  This trial tests whether retro-SCTLB or TPVB can reduce the need for opioid pain medicines after thoracoscopic radical lung cancer surgery.

  Recruiting Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu · NCT07745881

• QLESP Block to Ease Pain After Robot-Assisted Kidney Surgery

  Doctors are testing a ultrasound-guided nerve block called QLESP to see if it lowers pain and reduces strong pain medicines after robotic partial nephrectomy in adults.

  Recruiting Huazhong University of Science and Technology · Wuhan, Hubei · NCT07704970

• SPSIP Block to Help Pain After Breast Reduction Surgery

  A randomized trial tests whether adding an ultrasound-guided SPSIP block can lower opioid use in the first 24 hours after bilateral breast reduction surgery.

  Recruiting Cumhuriyet University Hospital · Sivas, Sivas · NCT07657949

• Shoulder Nerve Block Experience After Keyhole Surgery

  This study asks adults who had outpatient shoulder arthroscopic surgery with a single-shot nerve block to share their pain and recovery experiences to see if a nerve catheter might help some patients longer after surgery.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT07641842

• Bupivacaine plus lidocaine versus bupivacaine alone for ultrasound-guided popliteal sciatic nerve block

  This trial will test whether adding lidocaine to bupivacaine gives faster numbness and longer-lasting pain relief for adults having below-knee (foot or ankle) surgery with an ultrasound-guided popliteal sciatic nerve block.

  Recruiting Ataturk University · Erzurum · NCT07550348

• Comparing two ultrasound-guided chest wall nerve blocks for pain after mastectomy

  This study will see if one of two ultrasound-guided chest wall nerve blocks gives better pain relief and less opioid use for women having an elective mastectomy.

  Recruiting Uludag University · Bursa, Nilüfer · NCT07510269

• Combined transversus thoracic + serratus anterior plane blocks versus erector spinae plane block for pain after sternotomy

  This trial will try whether combining transversus thoracic and serratus anterior plane nerve blocks controls pain after median sternotomy better than an erector spinae plane block in adults having elective heart surgery.

  Recruiting Uludag University · Bursa, Nilüfer · NCT07452627

• Minimal Effective Volume for double-injection costoclavicular block

  This study tests the smallest amount of lidocaine that still provides a successful double-injection costoclavicular nerve block in adults having upper-extremity surgery.

  Recruiting Phase 4 McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT07374952

• PENG block plus local infiltration analgesia for anterior-approach hip replacement

  This test sees if a motor-sparing PENG block combined with local infiltration around the hip controls pain as well as spinal anesthesia for adults having anterior‑approach hip replacement.

  Recruiting ASST Gaetano Pini-CTO · Milan · NCT07239817

• Nerve block comparison for CT-guided lung nodule localization: retro‑SCTLB versus TPVB

  This trial will try two ultrasound-guided nerve blocks—retro‑SCTLB and thoracic paravertebral block (TPVB)—to see which gives wider local anesthetic spread and sensory numbness for adults having CT‑guided lung nodule localization.

  Recruiting at 2 sites Nanjing First Hospital, Nanjing Medical University · Nanjing, Jiangsu and 1 other locations · NCT07153263

• How Injection Time Affects Block Success in Gallbladder Surgery

  This study tests whether the speed of injecting anesthetic in fascial plane blocks changes how well the block works for people having laparoscopic gallbladder removal.

  Recruiting Bursa Yuksek Ihtisas Training and Research Hospital · Bursa · NCT07096765

• Intrathecal morphine and urinary retention after revision knee replacement

  This study will see if adding a small dose of spinal (intrathecal) morphine for adults having revision knee replacement lowers early pain but raises the chance of needing a urinary catheter.

  Recruiting Phase 3 University of Toronto · Toronto, Ontario · NCT07050277

• Immersive virtual reality versus mannequin training for the ultrasound-guided supra-inguinal fascia iliaca nerve block

  We will see if self-guided immersive virtual reality training works as well as mannequin-based training to teach anesthesiology, emergency medicine, and orthopedic staff and trainees how to perform an ultrasound-guided supra-inguinal fascia iliaca block.

  Recruiting The Ottawa Hospital · Ottawa, Ontario · NCT07035015

• Supra-inguinal fascia iliaca nerve block for pain after hip replacement

  This project will try a supra-inguinal fascia iliaca nerve block during primary total hip replacement to see if it reduces pain and the need for opioids afterward.

  Recruiting Institut Mutualiste Montsouris · Paris · NCT06982625

• Comparing two types of nerve blocks for pain management after lumbar surgery

  This study is testing two different nerve block techniques to see which one helps people have less pain and use fewer opioids after lumbar surgery.

  Recruiting Medipol University · Istanbul · NCT06851533

• Comparing two nerve block techniques for pain relief after hip surgery

  This study is testing which of two nerve block techniques helps people recover with less pain and fewer opioids after hip surgery.

  Recruiting Başakşehir Çam & Sakura City Hospital · Istanbul, Türki̇ye · NCT06821516

• Using remote guidance to improve regional anesthesia training

  This study tests whether using real-time remote guidance from expert anesthesiologists can help train doctors in ultrasound-guided regional anesthesia techniques to improve patient safety and satisfaction.

  Recruiting Queen's University · Kingston, Ontario · NCT05968261

• Comparing two methods for pain control after shoulder surgery

  This study is testing whether a new way of delivering pain relief after shoulder surgery works better than the standard method to help patients feel less pain and recover more comfortably.

  Recruiting Phase 4 University of Iowa · Iowa City, Iowa · NCT05868330

• Erector spinae plane block for managing pain after breast cancer surgery

  This study is testing if a special nerve block combined with a medication can help reduce pain and improve recovery for women after breast cancer surgery.

  Recruiting at 2 sites Peking University First Hospital · Beijing, Beijing Municipality and 1 other locations · NCT05494502

NIH-funded research (7)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Non-Addictive Nose Spray Nerve Block for Quick Migraine Relief

  A new nasal nerve-blocking treatment being tested to relieve migraine attacks quickly without addictive drugs.

  NIH research Olfax, LLC · Asheville, United States · NIH-11405684

• Block a nerve to help with opioid use disorder when on buprenorphine

  A new study will test whether injecting a local anesthetic near a facial nerve (SPG block) as an add-on to buprenorphine treatment can reduce withdrawal symptoms and improve treatment acceptance for people with opioid use disorder who use fentanyl.

  NIH research New York State Psychiatric Institute Dba Research Foundation for Mental Hygiene, INC · New York, United States · NIH-11353623

• Nerve block technique to reduce pain after wisdom tooth removal

  This study is looking at a new way to help manage pain and improve how well you can open your mouth after getting your wisdom teeth removed, using a special injection that could be a safer alternative to pain pills.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11033310

• Non-invasive electrical nerve block to reduce muscle spasticity

  This study is exploring a new way to help people with muscle tightness, like those with cerebral palsy, stroke, or spinal cord injuries, by using a gentle electrical technique that can reduce unwanted nerve signals and improve movement.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10814406

• Using partial electrical nerve block to improve heart function regulation

  This study is exploring a new way to help people with heart disease by using gentle electrical signals to fine-tune how the nerves control the heart, aiming to make it safer and easier to manage conditions like heart failure and irregular heartbeats.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-10756990

• A device to relieve pain from migraines and headaches without drugs

  This study is testing a new, easy-to-use device that helps people with migraines and headaches manage their pain without medication, and it's for anyone looking for a drug-free way to find relief.

  NIH research Thermaquil, INC. · Philadelphia, United States · NIH-10493404

• A device for providing pain relief through electrical nerve blocks.

  This study is testing a new, easy-to-use device that sends gentle electrical signals to help relieve knee pain for people with osteoarthritis, aiming to improve their movement and daily life without the need for surgery or strong pain medications.

  NIH research H-Cubed, INC. · Olmsted Falls, United States · NIH-10482175

Related topics

Quick answers

How many Nerve Block clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 6 countries. The most sites are in Turkey (Türkiye) (7 trials), Canada (5 trials), China (4 trials), France (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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