Bupivacaine plus lidocaine versus bupivacaine alone for ultrasound-guided popliteal sciatic nerve block

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective, randomized, double-blind, single-center trial at Ataturk University comparing two local anesthetic regimens for ultrasound-guided popliteal sciatic nerve block in adults undergoing elective distal lower extremity surgery. Sixty patients aged 18–65 (ASA I–III, BMI 18–35) will be randomized 1:1 to receive either 10 mL 2% lidocaine plus 10 mL 0.5% bupivacaine or 20 mL 0.5% bupivacaine alone prior to surgery. The primary outcome is onset time of sensory and motor blockade; secondary outcomes include block success rate, duration of sensory and motor block, postoperative opioid consumption, Numeric Rating Scale pain scores at 2, 4, 8, 12, and 24 hours, QoR-15 score, and incidence of rebound pain. Ultrasound guidance and standardized block technique will be used to ensure consistent administration across participants.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age between 18 and 65 years
* American Society of Anesthesiologists (ASA) physical status classification I, II, or III
* Scheduled for elective distal lower extremity surgery (below-knee)
* Body mass index (BMI) between 18 and 35 kg/m²
* Provision of written informed consent

Exclusion Criteria:

* Refusal to participate in the study
* Morbid obesity (BMI ≥35 kg/m²)
* Known allergy or hypersensitivity to any local anesthetic agent
* Severe cardiac, hepatic, or renal disease
* Pre-existing neurological deficits or peripheral neuropathy
* Use of anticoagulant therapy
* History of prior surgery or significant scar tissue in the popliteal fossa
* Pregnancy
* Chronic opioid use at home

Where it's running

• Ataturk University
  Erzurum, Turkey (Türkiye) Recruiting

Study contacts

• Principal investigator: AHMET MURAT YAYIK, MD, PhD — Ataturk University Faculty of Medicine, Department of Anesthesiology and Reanimation
• Study coordinator: AHMET MURAT YAYIK, MD, PhD
• Email: ahmetmuratyayik@gmail.com
• Phone: +95544259287

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.