Aloe vera gel versus paraffin tulle dressings for donor-site pain after split-thickness skin grafts
Official title: Comparison of Postoperative Pain After Application of Aloe Vera Gel Dressings With Conventional Paraffin-Based Tulle Dressings at Split-Thickness Skin Graft Donor Site
Run by King Edward Medical University · NCT07057557 · Data updated 2026-11-12
This trial tests whether Aloe vera gel dressings reduce pain more than paraffin tulle dressings for adults (18–60) after split-thickness skin graft donor-site wounds.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 60 Years |
| Sex | All |
| Enrollment | 72 (estimated) |
| Sponsor | King Edward Medical University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Lahore, Punjab Province) |
| Status | Recruiting |
| Started | August 5, 2025 |
| Main results expected | February 5, 2026 |
| Study ends | April 14, 2026 |
| Registry record updated | September 25, 2025 |
| Trial ID | NCT07057557 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults aged 18–60 who need a split-thickness skin graft, can undergo general anesthesia, and do not have conditions that alter pain response or allergies to the dressings are ideal candidates.
✕Probably not a fit
Patients with diabetes, neuropathy, ongoing chemotherapy or opioid use, altered pain perception, allergies to dressing components, or those outside the 18–60 age range may not benefit or are excluded.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized controlled trial at Mayo Hospital, Lahore will enroll 72 adults undergoing split-thickness skin grafting and randomize them to receive either Aloe vera gel dressings or conventional paraffin-based tulle dressings at the donor site. Dressings will be applied with identical secondary dressings, and grafts will be harvested at a uniform thickness under general anesthesia. Pain will be measured using a visual analogue scale on postoperative day 7 and any supplemental analgesic use will be recorded. The trial runs over six months and excludes patients with altered pain perception or known allergies to the dressings.
Why it matters
Potential benefit: If successful, the Aloe vera dressing could reduce donor-site pain and lower the need for additional pain medication, improving comfort and recovery.
How similar studies have gone: Aloe vera has shown benefit for pain and healing in burns and superficial wounds, but randomized comparisons specifically for STSG donor-site pain are limited.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * • Patients aged 18-60 years of age of either gender needing Split thickness skin graft Exclusion Criteria: * • Patients known to have exaggerated/diminished pain response due to certain medical conditions (e.g. diabetes, neuropathy, chemotherapy, opioids etc.) * Patients allergic to either dressings
Where it's running
-
Mayo Hospital Lahore
Lahore, Punjab Province, Pakistan Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.