Aloe vera gel versus paraffin tulle dressings for donor-site pain after split-thickness skin grafts
Comparison of Postoperative Pain After Application of Aloe Vera Gel Dressings With Conventional Paraffin-Based Tulle Dressings at Split-Thickness Skin Graft Donor Site
This trial tests whether Aloe vera gel dressings reduce pain more than paraffin tulle dressings for adults (18–60) after split-thickness skin graft donor-site wounds.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 72 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | King Edward Medical University Academic / other |
| Drugs / interventions | chemotherapy |
| Locations | 1 site (Lahore, Punjab Province) |
| Trial ID | NCT07057557 on ClinicalTrials.gov |
What this trial studies
This randomized controlled trial at Mayo Hospital, Lahore will enroll 72 adults undergoing split-thickness skin grafting and randomize them to receive either Aloe vera gel dressings or conventional paraffin-based tulle dressings at the donor site. Dressings will be applied with identical secondary dressings, and grafts will be harvested at a uniform thickness under general anesthesia. Pain will be measured using a visual analogue scale on postoperative day 7 and any supplemental analgesic use will be recorded. The trial runs over six months and excludes patients with altered pain perception or known allergies to the dressings.
Who should consider this trial
Good fit: Adults aged 18–60 who need a split-thickness skin graft, can undergo general anesthesia, and do not have conditions that alter pain response or allergies to the dressings are ideal candidates.
Not a fit: Patients with diabetes, neuropathy, ongoing chemotherapy or opioid use, altered pain perception, allergies to dressing components, or those outside the 18–60 age range may not benefit or are excluded.
Why it matters
Potential benefit: If successful, the Aloe vera dressing could reduce donor-site pain and lower the need for additional pain medication, improving comfort and recovery.
How similar studies have performed: Aloe vera has shown benefit for pain and healing in burns and superficial wounds, but randomized comparisons specifically for STSG donor-site pain are limited.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * • Patients aged 18-60 years of age of either gender needing Split thickness skin graft Exclusion Criteria: * • Patients known to have exaggerated/diminished pain response due to certain medical conditions (e.g. diabetes, neuropathy, chemotherapy, opioids etc.) * Patients allergic to either dressings
Where this trial is running
Lahore, Punjab Province
- Mayo Hospital Lahore — Lahore, Punjab Province, Pakistan (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.