Comparing ketamine delivery methods for postoperative pain management in orthopedic surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to evaluate the effectiveness of intravenous ketamine administered as a continuous infusion versus a patient-controlled analgesia (PCA) pump for managing postoperative pain in adults undergoing major orthopedic surgery. Participants will be randomly assigned to receive either method, and their pain levels and opioid consumption will be monitored over the first 24 hours post-surgery. The study seeks to determine which method provides better pain control and reduces the need for opioids, addressing a critical aspect of postoperative care.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients over 18 years of age
* Elective major orthopedic surgery.
* ASA (American Association of Anesthesiology) classification 1, 2 or 3.

Exclusion Criteria:

* Patients with a diagnosis of perioperative kidney injury or hepatic failure
* Patients with active cardiac conditions
* Patients with any cognitive impairment that disables the patient from operating the PCA pump or impedes the postoperative interview
* Patients with scheduled ICU admission with invasive ventilatory support
* Patients with known hypersensitivity to opioid medications
* Patients with past medical history of severe adverse reactions to opioids or ketamine.
* Pregnant patients
* Patients undergoing continuous regional anesthetic techniques including peripheral nerve catheters or continuous epidural catheters
* Patient refusal to participate in the study

Where it's running

• St. Vincent's Foundation University Hospital
  Medellín, Antioquia, Colombia Recruiting

Study contacts

• Study coordinator: Fabian D Casas, Professor
• Email: fabian.casas@udea.edu.co
• Phone: +57 (604) 300574882

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.