Effects of Buprenorphine, Clonidine, and Dexamethasone on Pain Management After Shoulder Surgery
Effects of a Triple Adjuvant Combination of Buprenorphine, Clonidine, and Dexamethasone on Duration of Brachial Plexus Blocks for Upper Extremity Surgery, a Prospective, Randomized Clinical Trial
This study is testing if adding buprenorphine, clonidine, and dexamethasone to a common pain relief method can help people manage pain better after shoulder surgery.
Quick facts
| Phase | Phase 4 |
|---|---|
| Study type | Interventional |
| Enrollment | 120 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Loyola University Academic / other |
| Locations | 1 site (Maywood, Illinois) |
| Trial ID | NCT05824832 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to evaluate the impact of adding buprenorphine, clonidine, and dexamethasone to Interscalene brachial plexus blocks on postoperative pain management in patients undergoing shoulder arthroscopy. A total of 120 patients will be randomly assigned to receive either the enhanced block with adjuvants or the standard block alone. The primary outcome is to assess differences in morphine requirements post-surgery between the two groups. This prospective, randomized, single-blinded study seeks to determine if the addition of these medications can improve pain control.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older who are scheduled for shoulder arthroscopy and are willing to participate.
Not a fit: Patients with severe COPD, chronic pain requiring daily opioid use, or those with contraindications to general anesthesia may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management strategies for patients undergoing upper extremity surgeries.
How similar studies have performed: Previous studies have shown promising results with similar approaches in enhancing pain management after surgical procedures.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients ≥ 18 years old * Patients undergoing shoulder arthroscopy * Patients willing to participate and sign informed consent Exclusion Criteria: * Severe COPD/other contraindication to general anesthesia * Patient with a weight of less than 60 kg * Dementia, not alert or oriented to person, place, or time * Chronic pain patient with daily opioid use at home. * Patient with allergy to local anesthetics * Patient refusal * Total shoulder arthroplasty * Concomitant pain in different area from operative site. * Pregnancy * Patient with active infection on the injection sites for the blocks * Patients unable or willing to understand or comply with the study protocol
Where this trial is running
Maywood, Illinois
- Loyola University Chicago — Maywood, Illinois, United States (Recruiting)
Study contacts
- Principal investigator: Audrice Francois, MD — Loyola University Chicago
- Study coordinator: Susan Fargo
- Email: sfargo@luc.edu
- Phone: 708-216-8046
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.