Using gabapentin before wisdom teeth removal to reduce pain and opioid use

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of administering 600 mg of gabapentin two hours before wisdom teeth extraction to reduce intraoperative and postoperative opioid use while managing pain. It is a double-blind, randomized, placebo-controlled study involving 49 patients, who will be monitored for pain severity, opioid consumption, and side effects at various intervals post-surgery. The goal is to determine if gabapentin can provide adequate pain control and minimize reliance on opioids during recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects must be at or older than 18.
* Screened body mass index (BMI) between 18-35 kg/m2.
* American Society of Anesthesiologists Classification I and II.
* Subjects must be willing and able to comply with protocol requirements.
* Subjects must be able to understand the informed consent and must be able to sign a written informed consent form prior to the initiation of any study procedures.
* A subject must have at least 1 partial or fully impacted third molar tooth removal.

Exclusion Criteria:

* hypersensitivity to gabapentinoids;
* history of chronic opioid or gabapentin usage (regular use of opioids \>3 months)
* history of recreational drug usage
* a history or clinical manifestations of significant metabolic, hematologic, pulmonary, cardiovascular, gastrointestinal, neurologic, hepatic, renal, urologic, musculoskeletal, psychiatric, or immunologic disorder, any acute, clinically significant illness or condition within 14 days prior to Day 1.
* Patients with baseline pain.
* Patients with any oral pathology will be excluded.
* Pregnant or breastfeeding patients
* An individual not legally competent to consent (e.g., incapacitated individuals, incompetents, minors)

Where it's running

• Loma Linda University Health
  Loma Linda, California, United States Recruiting

Study contacts

• Principal investigator: Chi Viet, DDS MD PhD — Loma Linda University
• Study coordinator: Je Dong Ryu, DMD MD
• Email: jryu@llu.edu
• Phone: 909-558-4423

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.