PENG block plus local infiltration analgesia for anterior-approach hip replacement

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized comparison assigns adults having anterior‑approach hip endoprosthesis to either an ultrasound‑guided anterior/posterior PENG block combined with local infiltration analgesia (LIA) or to standard spinal anesthesia. The PENG+LIA arm uses targeted pericapsular sensory injections (A‑PENG and PONG) and a 360° LIA protocol intended to provide surgical anesthesia without major motor blockade. Primary outcomes include pain scores over the first 48 hours and time to first mobilization, with secondary outcomes capturing nausea and other side effects. The aim is to determine whether pain control is similar while allowing earlier leg movement and rehabilitation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Provision of signed and dated informed consent form.
* Scheduled for hip endoprosthesis surgery for femoral fracture with an anterior, lateral or posterolateral approach (any approach).
* Age 18 years or older.
* Willing and able to comply with the study protocol.

Exclusion Criteria:

* Failure to provide informed consent.
* Age less than 18 years.
* Known allergy to local anesthetics or other medications used in the protocol.
* Presence of infection at the planned injection site.
* Pre-existing hip prosthesis or prior major surgery on the same hip (e.g., revision surgery).
* ASA physical status class \> IV.
* Administration of intraoperative opiates or conversion to general anesthesia.

Where it's running

• Gaetano Pini-CTO
  Milan, Italy Recruiting

Study contacts

• Principal investigator: Romualdo Del Buono, MD — Unit of Anesthesia, Intensive Care and Pain Management, ASST Gaetano Pini, Milan, Italy;
• Study coordinator: Romualdo Del Buono, MD
• Email: romualdo.delbuono@asst-pini-cto.it
• Phone: +39 02 5829 6592

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.