Condition

Total Knee Arthroplasty clinical trials and research

• 51Clinical trials
• 17NIH research projects
• 1New in 30 days
• 21Countries

Newest Total Knee Arthroplasty clinical trials

All recruiting trials (51)

• Mind mapping-based education to help after knee replacement

  A group of adults having total knee replacement will receive mind-mapping education in addition to standard care to see if it helps with pain, fear of movement, and readiness to leave the hospital.

  Recruiting Inonu University · Batman · NCT07885449

• DoACs vs LMWH for blood flow after knee replacement

  This study tests whether rivaroxaban, apixaban, or LMWH work differently to support blood flow in the legs after total knee replacement in adults.

  Recruiting Military Hospital of Tunis · Tunis, Tunis Governorate · NCT07869615

• Branched chain amino acids after knee replacement to help muscle

  This trial tests whether giving Livact after knee replacement helps preserve muscle and function in adults with sarcopenia.

  Recruiting at 2 sites Phase 4 Seoul National University Hospital · Seongnam-si, Gyeonggi-do and 2 other locations · NCT07634523

• Cryotherapy to Cut Opioid Use After Knee Replacement

  This trial tests whether compressive cryotherapy with a Game Ready device can lower opioid use and improve recovery after total knee replacement in adults 60–80.

  Recruiting Hospital Italiano de Buenos Aires · Buenos Aires, Buenos Aires · NCT07630337

• Early cognitive changes after same-day hip or knee replacement

  This study tests whether older adults (65 or older, 70 per description) who have same-day discharge after hip or knee replacement show changes in cognitive test performance from before surgery to the first day after surgery.

  Recruiting Odense University Hospital · Svendborg · NCT07598552

• Preoperative Genicular Nerve Block for Knee Replacement

  This study tests whether giving a genicular nerve block before knee replacement can reduce pain after surgery and lower opioid use.

  Recruiting Helse Møre og Romsdal HF · Hjelset, Møre og Romsdal · NCT07589127

• BiFeS and adductor canal block for pain after knee replacement

  This study tests whether adding a BiFeS block and adductor canal block to spinal anesthesia reduces opioid use and improves pain control after total knee arthroplasty.

  Recruiting Kayseri City Hospital · Kayseri, Kocasinan · NCT07577869

• ACB plus IPACK versus ACB plus BiFeS blocks for pain control after total knee replacement

  This trial will test whether adding an IPACK or a BiFeS block to an adductor canal block gives better pain relief for adults (18–80) having primary total knee replacement under spinal anesthesia.

  Recruiting Hitit University · Çorum, Centre · NCT07561333

• AI-assisted anatomical visualization to reduce anxiety and fear of movement before knee replacement

  This trial tests whether AI-enhanced visualization training helps people 55+ with knee osteoarthritis see and understand their knee replacement better and fear less about moving after surgery.

  Recruiting Munzur University · Elâzığ, Ulukent · NCT07545447

• Comparing femoral triangle and adductor canal nerve blocks for early quadriceps function after knee replacement

  This test compares two nerve blocks — femoral triangle block and adductor canal block — to see which causes less early quadriceps weakness in adults having a single knee replacement.

  Recruiting Social Medical Corporation Daiyukai · Ichinomiya, Aichi-ken · NCT07524387

• 72-hour knee extension brace after total knee replacement

  This will try wearing a knee extension brace for the first 72 hours after a primary knee replacement to see if it reduces early pain and improves recovery.

  Recruiting Université de Sherbrooke · Sherbrooke, Quebec · NCT07511842

• One preoperative dose of IV methadone for pain after knee replacement

  This study tests whether a single IV methadone dose given before total knee replacement can improve postoperative pain control and reduce later pain medicine use for patients undergoing the surgery.

  Recruiting Phase 4 AdventHealth · Denver, Colorado · NCT07485803

• Local infiltration analgesia vs quadruple nerve blocks for total knee replacement

  This study tests whether a surgical local infiltration analgesia approach can provide similar pain relief to quadruple nerve blocks after total knee arthroplasty.

  Recruiting CMC Ambroise Paré · Toulouse, Haute-Garonne · NCT07477730

• Oral vs IV Dexamethasone in Knee Replacement Recovery

  This real-world study compares how giving dexamethasone by mouth or by IV around knee replacement affects early pain, movement, and recovery.

  Recruiting Haseki Training and Research Hospital · Istanbul, Istanbul · NCT07442812

• Binaural beats to reduce pain and anxiety after hip or knee replacement

  This will try a 30-minute binaural beats audio session in the PACU to see if it lowers pain and anxiety for adults having same-day total hip or knee replacement.

  Recruiting University of Miami · Miami, Florida · NCT07437469

• Noise-cancelling headsets to reduce sedation during knee replacement

  This study will test whether giving people having total knee replacement active noise-cancelling headphones with music or a movie during spinal anesthesia can reduce how much sedation they need.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07371390

• Predicting recovery after knee replacement using smart insoles and AI

  This study will test whether preoperative clinical information and walking data from instrumented insoles can help predict recovery six weeks after total knee replacement for adults with knee osteoarthritis.

  Recruiting Yonsei University · Yongin-si, Gyeonggi-do · NCT07367789

• Optimizing preoperative nutrition and fasting for total knee replacement

  This trial will test whether an ERAS-based preoperative nutrition education and fasting plan helps people having elective total knee replacement stay better hydrated and have less nausea and vomiting after surgery.

  Recruiting Acibadem University · Istanbul, Istanbul · NCT07336160

• Methylene blue dye to measure how much irrigation clears contamination during knee replacement procedures

  We will test whether putting methylene blue dye into the knee during replacement or DAIR procedures can show how much irrigation is needed to wash out contaminants.

  Recruiting Phase 1 University of Miami · Miami, Florida · NCT07324954

• Vancomycin given into the joint, into bone, or by IV during total knee replacement

  This trial will test whether a single dose of vancomycin injected into the knee joint before a primary total knee replacement protects against infection as well as vancomycin given into bone or by IV for adults treated at UC San Diego.

  Recruiting Phase 4 University of California, San Diego · San Diego, California · NCT07282782

• Adding targeted posterior knee nerve blocks to the adductor canal block for pain control after total knee replacement

  This trial will test whether adding one of three different posterior knee nerve blocks to a standard adductor canal block reduces pain and opioid use for adults having a single total knee replacement.

  Recruiting Erzincan University · Erzincan, Merkez · NCT07242170

• BT-114143 to reduce bleeding during total knee replacement

  This trial will test whether two doses of BT-114143 given before and after surgery reduce blood loss in adults having a single total knee replacement compared with standard tranexamic acid.

  Recruiting Phase 2 ScinnoHub Pharmaceutical Co., Ltd. · Chengdu, Si'Chuan · NCT07127042

• Regional anesthesia for knee replacement: effects on early joint motion and patient satisfaction

  We will test whether three different regional anesthesia approaches — an epidural catheter, an adductor canal catheter, or multimodal IV pain control — help adults having elective knee replacement move their knee better and feel more satisfied after surgery.

  Recruiting Konya City Hospital · Konya, Meram · NCT07124494

• Comparing two regional anesthesia techniques for knee replacement

  This trial tests whether ultrasound-guided supra-inguinal fascia iliaca block or ultrasound-guided adductor canal block (with iPACK as part of the regimen) gives better pain control and less opioid use for adults having total knee replacement.

  Recruiting SB Istanbul Education and Research Hospital · Istanbul · NCT07092982

• Choose to Move Replacement Ready for people waiting for hip or knee replacement

  This project will test whether the Choose to Move Replacement Ready program helps older adults on hip or knee replacement waitlists increase physical activity, improve mobility, and support psychosocial health.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07069179

• Comparing cold-therapy programs after total knee replacement

  We'll test different cold-therapy methods—ice packs versus ice water, and continuous versus intermittent cooling—to see which reduces pain and improves comfort after total knee replacement.

  Recruiting at 2 sites The Fourth Affiliated Hospital of Zhejiang University School of Medicine · Yiwu, Zhejiang and 1 other locations · NCT07021287

• Brain-computer visualization training to improve muscle activation after orthopedic surgery

  This tests whether adding EEG-based neurofeedback visualization to usual physical therapy helps adults recovering from ACL, hip, or knee surgery activate their muscles better and speed recovery.

  Recruiting Phase 2 Rush University Medical Center · Chicago, Illinois · NCT07020312

• Cryoablation to reduce pain after total knee replacement

  This trial tests whether adding cryoablation during total knee replacement helps people have less pain and need fewer opioid pain medicines.

  Recruiting NYU Langone Health · New York, New York · NCT06991231

• Smart knee implants and patient satisfaction after knee replacement

  This study will see if smart knee implants that send recovery data can help people recover, stay satisfied, and reduce clinic visits after knee replacement.

  Recruiting University of Chicago · Chicago, Illinois · NCT06968143

• Using virtual reality to enhance outcomes in knee surgery

  This study is testing if using virtual reality during knee surgery can help patients feel less anxious and in less pain while needing less sedation.

  Recruiting Belfast Health and Social Care Trust · Belfast · NCT06962046

• Using electrical stimulation to improve recovery after knee surgery

  This study is testing if using electrical stimulation can help people recover better and get stronger after knee surgery compared to regular rehab.

  Recruiting at 3 sites University of Colorado, Denver · Aurora, Colorado and 2 other locations · NCT06953375

• Comparing two types of tourniquets during knee surgery

  This study is testing which of two types of tourniquets used during knee surgery can help reduce blood loss and improve the overall experience for both patients and surgeons.

  Recruiting University Hospital, Bonn · Bonn, North Rhine-Westphalia · NCT06947655

• Surgeon-administered Exparel for pain control during total knee replacement

  This study will test whether a surgeon‑administered Exparel IPSA block with local infiltration provides similar or better pain relief than an anesthesiologist‑administered adductor canal block for adults having a primary unilateral total knee replacement.

  Recruiting The Cleveland Clinic · Cleveland, Ohio · NCT06946368

• Robotic Mako cementless versus cemented total knee replacement

  This study will test whether robotic Mako cementless or cemented knee replacements work better for adults having a primary total knee replacement for osteoarthritis.

  Recruiting University College, London · London · NCT06929871

• Quadruple block plus adductor canal block for knee surgery pain

  This study tests whether adding a quadruple nerve block to the standard adductor canal block reduces pain after total knee replacement.

  Recruiting GCS Ramsay Santé pour l'Enseignement et la Recherche · Quincy-sous-Sénart and 1 other locations · NCT06920186

• Combining two methods for pain relief after knee surgery

  This study is testing if using a combination of a nerve block and a medication can help people feel less pain after knee surgery.

  Recruiting Kafrelsheikh University · Kafr ash Shaykh, Kafrelsheikh · NCT06837844

• Comparing two knee replacement techniques for better outcomes

  This study is testing two different knee replacement techniques to see which one helps people with knee osteoarthritis feel better and move more easily after surgery.

  Recruiting Phase 4 McMaster University · Hamilton, Ontario · NCT06787417

• Different doses of liposomal bupivacaine for adductor canal block after total knee replacement

  This will test whether different doses of liposomal bupivacaine given in the adductor canal block reduce pain and opioid use after elective total knee replacement in adults.

  Recruiting Phase 3 The University of Hong Kong · Hong Kong, Hong Kong · NCT06740214

• Comparing two methods of antibiotic delivery during knee surgery

  This study is testing whether giving antibiotics directly into the bone during knee surgery works better than the usual method of giving them through an IV to help reduce complications after surgery.

  Recruiting Phase 1/2 The Methodist Hospital Research Institute · Houston, Texas · NCT06640491

• Teleprehabilitation program for knee replacement surgery

  This study is testing a new online program to help people getting knee replacement surgery prepare better and recover faster compared to regular pre-surgery advice.

  Recruiting at 2 sites Universitair Ziekenhuis Brussel · Geel, Antwerpen and 1 other locations · NCT06565377

• Comparing pain relief from two medications after knee surgery

  This study tests whether mirogabalin or pregabalin works better to relieve pain after knee surgery for people aged 50-85 with osteoarthritis.

  Recruiting Thammasat University Hospital · Khlong Luang, Changwat Pathum Thani · NCT06328062

• Evaluation of the FHK®-CK Knee Prosthesis for Knee Replacement

  This study is testing a new knee replacement device to see if it works well and is safe for patients with complex knee issues or those who have had previous surgeries.

  Recruiting at 6 sites Fh Ortho · Beaumont and 6 other locations · NCT06124482

• Reducing oxidative stress to prevent chronic pain after knee surgery

  This study is testing if a special antioxidant can help people who have knee surgery feel less pain and recover better.

  Recruiting Phase 4 Vanderbilt University Medical Center · Nashville, Tennessee · NCT06083480

• Comparing A-Linker and Walker for Mobility After Knee Surgery

  This study is testing whether using a new mobility device called the A-Linker helps people move better after knee surgery compared to using a standard walker.

  Recruiting Stanford University · Redwood City, California · NCT06080152

• Evaluating the NextAR System for Knee Surgery Outcomes

  This study is testing if a new navigation system for knee surgery can help patients have better knee alignment and outcomes after their total knee replacement.

  Recruiting Medacta International SA · Fremantle · NCT05863741

• Comparing two types of knee implants using robotic assistance

  This study is testing which of two different knee implants works better for patients getting knee replacement surgery with the help of a robotic system.

  Recruiting NYU Langone Health · New York, New York · NCT05391828

• Evaluation of Multigen Plus CCK and AMF TT Cones in Knee Surgery

  This study is testing how well a new knee replacement device works for people with joint instability after surgery, comparing results with and without special support cones.

  Recruiting at 3 sites Limacorporate S.p.a · Guimarães and 2 other locations · NCT05314491

• Improving rehabilitation for veterans after knee surgery

  This study is testing a new tool to help veterans recover better after knee surgery by personalizing their rehabilitation based on their individual needs and goals.

  Recruiting at 2 sites VA Office of Research and Development · Aurora, Colorado and 1 other locations · NCT05288803

• Using Medrol Dosepak to manage pain after knee surgery

  This study is testing if a medication called Medrol can help people feel less pain and recover better after knee surgery compared to a placebo.

  Recruiting Phase 4 Rush University Medical Center · Oak Brook, Illinois · NCT05097976

• Evaluation of a new knee implant material in total knee replacement surgery

  This study is testing a new knee implant material in people getting knee replacement surgery to see how it works and if it causes any reactions.

  Recruiting Medacta International SA · Milan, MI · NCT04801654

• Comparing cemented and uncemented methods for knee replacement surgery

  This study is testing whether using cemented or uncemented methods for knee replacement surgery works better for patients in terms of how long the implants last and how well they attach to the bone.

  Recruiting at 2 sites Hospices Civils de Lyon · Lyon and 1 other locations · NCT04692714

NIH-funded research (17)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How bone density and joint loads affect implant migration after knee replacement

  A knee replacement project explores how bone density and how the knee is loaded relate to early implant movement that could lead to loosening.

  NIH research Hospital for Special Surgery · New York, UNITED STATES · NIH-11433151

• Cannabidiol to reduce opioid use after knee replacement surgery

  A clinical trial tests whether CBD can help lower opioid needs after knee replacement without extra side effects.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11401961

• Neuromuscular electrical stimulation after knee replacement

  This project tests whether using electrical stimulation of the thigh muscles after knee replacement helps people recover strength and function faster.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11391102

• Multimodal Pain Help After Knee Replacement

  A new approach aims to reduce persistent pain after knee replacement by using a minimally invasive nerve-stimulation therapy along with standard care.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11295096

• Cannabidiol (CBD) to reduce opioid use after knee replacement

  This trial will see if taking cannabidiol (CBD) around the time of a knee replacement helps people use fewer opioid pain medicines after surgery.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11192350

• Lowering oxidative stress around knee replacement to reduce long-term pain

  This trial gives an antioxidant medicine around the time of knee replacement to help reduce long-term pain for people having total knee arthroplasty.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11171771

• Electrical stimulation to boost quadriceps recovery after knee replacement

  This project uses small neuromuscular electrical stimulation during rehab to help people regain quadriceps strength after total knee replacement.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11169853

• Better Swelling Control After Knee Replacement Surgery

  This project is exploring if a special compression garment can help reduce swelling and improve recovery for people who have had total knee replacement surgery.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11143164

• Improving rehabilitation for veterans after knee surgery

  This study is all about helping veterans recover better after knee surgery by creating a special tool that uses past recovery information to predict how each person will heal, so doctors can give the right support and care tailored just for them.

  NIH research VA Eastern Colorado Health Care System · Aurora, UNITED STATES · NIH-11056763

• Using electrical stimulation to improve recovery after knee surgery

  This study is looking at how using a special electrical stimulation can help people get their leg strength back after knee surgery, making it easier for them to recover and get back to their daily activities.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10977557

• Reducing oxidative stress to help prevent chronic pain after knee surgery

  This study is looking at whether taking an antioxidant before and during knee surgery can help reduce pain after the operation, and it's for people who are having total knee replacement surgery.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-10933522

• Using cannabidiol to reduce opioid use after knee surgery

  This study is looking at whether CBD can help manage pain after knee surgery instead of using opioids, and it's for people who are having total knee replacements and want to explore safer pain relief options.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10930869

• Training to prevent falls after knee surgery

  This study is testing a special training program to help older adults who have had knee surgery learn how to stay steady and avoid falls while they recover.

  NIH research University of Illinois at Chicago · Chicago, UNITED STATES · NIH-10911142

• Managing swelling after knee replacement surgery

  This study is looking at a new adjustable compression garment to help reduce swelling after knee replacement surgery, which could make recovery easier and improve your overall healing.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10897974

• Reducing opioid use before knee surgery

  This study is looking at a new way to help people reduce their use of opioids before they have knee surgery, which can lead to less pain and a smoother recovery afterward.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10896978

• Understanding how some patients develop chronic pain after knee replacement surgery.

  This study is looking at what helps some people avoid long-lasting pain after knee surgery, so if you're having a total knee replacement, your experiences and feelings could help us find ways to keep others from developing chronic pain.

  NIH research Rush University Medical Center · Chicago, United States · NIH-10593786

• Understanding pain after knee surgery in older adults

  This study is looking at why some older adults develop long-lasting pain after knee surgery and aims to find out what helps some people cope better than others, so we can improve recovery for everyone.

  NIH research Rush University Medical Center · Chicago, United States · NIH-10231116

Related topics

Quick answers

How many Total Knee Arthroplasty clinical trials are recruiting right now?

51, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 21 countries. The most sites are in United States (16 trials), Turkey (Türkiye) (9 trials), France (4 trials), United Kingdom (3 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 6, Phase 2: 2, Phase 3: 1, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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