Liposomal vs Standard Bupivacaine for Post-Rhinoplasty Pain

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this Phase 2 interventional trial, adults undergoing open rhinoplasty are randomly assigned to receive either liposomal bupivacaine or standard bupivacaine as a nerve block during surgery. Pain levels are tracked for several days after the procedure, and safety and recovery are monitored. The goal is to determine which formulation more effectively reduces postoperative pain and supports smoother healing. The study is conducted at Washington University School of Medicine in St. Louis.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients (≥18 years) undergoing open rhinoplasty of any indication or complexity (e.g., primary, revision, functional, or cosmetic), including autologous grafting of any type (e.g., septal or costal cartilage) or cadaveric grafting.

Exclusion Criteria:

* Chronic pain condition requiring ongoing or scheduled analgesic therapy, or any diagnosis associated with chronic pain (e.g., fibromyalgia, chronic headache/migraine, neuropathic pain, complex regional pain syndrome), long-term opioid use (≥3 months, any agent), allergy or contraindication to local anesthetics, acetaminophen, ibuprofen / NSAIDs, tramadol, ketamine, Medrol (methylprednisolone) dose pack
* Concurrent non-nasal surgery planned

Where it's running

• Washington University
  St Louis, Missouri, United States Recruiting

Study contacts

• Principal investigator: Matthew Wu, MD — Washington University School of Medicine
• Study coordinator: Matthew Wu, MD
• Email: mjwu@wustl.edu
• Phone: 314-362-0524

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.