Opioid-free anesthesia for breast cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of opioid-free anesthesia (OFA) compared to conventional general anesthesia (CGA) in patients undergoing breast cancer surgeries such as lumpectomy or mastectomy. The study aims to evaluate postoperative analgesic requirements, cognitive function, and adverse events in the first 48 hours after surgery. Additionally, it will assess intraoperative hemodynamics and the length of hospital stay. By avoiding opioids, the trial seeks to minimize the undesirable side effects associated with opioid use.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* adult patients
* breast cancer surgery (mastectomy, lumpectomy, with or without lymph node excision) under general anaesthesia

Exclusion Criteria:

* under 18 years
* patient refusal
* opioid use (systemic or not) for any reason (e.g., chronic malignant pain)
* language barrier (difficulty in communicating in Greek language)
* allergy to the administered agents
* severe arrhythmia or other serious cardiac disease
* severe liver and kidney failure
* dementia, psychiatric diseases, and/or preoperative cognitive impairment

Where it's running

• University Hospital of Ioannina
  Ioannina, Epirus, Greece Recruiting

Study contacts

• Study coordinator: Agathi Karakosta
• Email: akarakosta@uoi.gr
• Phone: +306948066243

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Evaluating sensation and satisfaction in cancer and transgender mastectomy patients

  This study is testing if advanced surgical techniques can improve sensation and satisfaction for people undergoing gender-affirming mastectomy and breast reconstruction.

  Recruiting at 2 sites Weill Medical College of Cornell University · Boston, Massachusetts and 1 other locations · NCT06094257

• Documenting opioid use and pain management after surgery

  This study looks at how opioids are used for pain management after surgery in adults to see how it affects their recovery and quality of life over time.

  Recruiting University of Aberdeen · Zagreb, Vinogradska 29 and 3 other locations · NCT05877157

• Reducing post-mastectomy pain with opioid-free anesthesia

  This study is testing whether using anesthesia without opioids can help women who have had a mastectomy experience less chronic pain a year after their surgery compared to traditional opioid-based anesthesia.

  Recruiting Gangnam Severance Hospital · Seoul · NCT05146778

• Evaluating pain pathways and nerve regeneration in keratoconus patients after corneal crosslinking

  This study is testing how corneal crosslinking affects pain and nerve healing in people with keratoconus to see how their pain changes over time.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT04439552

• Gyrotonic exercise for elders with breast cancer and Behcet disease

  We’re testing whether a gyrotonic exercise program helps older people who have both Behcet disease and breast cancer.

  Recruiting Cairo University · Giza, Dokki · NCT07929116

• PECS II vs SPSIP nerve blocks for pain after mastectomy

  This study tests whether two ultrasound-guided nerve blocks (PECS II and SPSIP) differ in how much opioid patients need after mastectomy.

  Recruiting Bursa City Hospital · Nilufer, Bursa · NCT07929090

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.