Opioid-free anesthesia for breast cancer surgery
A Comparative Evaluation of Opioid Free Anaesthesia Technique Versus the Conventional Technique in Oncological Breast Surgery
This study tests whether using opioid-free anesthesia during breast cancer surgery can help patients recover better and have fewer side effects compared to traditional anesthesia.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 200 (estimated) |
| Ages | 18 Years to 99 Years |
| Sex | Female |
| Sponsor | University of Ioannina Academic / other |
| Locations | 1 site (Ioannina, Epirus) |
| Trial ID | NCT06404983 on ClinicalTrials.gov |
What this trial studies
This clinical trial investigates the effects of opioid-free anesthesia (OFA) compared to conventional general anesthesia (CGA) in patients undergoing breast cancer surgeries such as lumpectomy or mastectomy. The study aims to evaluate postoperative analgesic requirements, cognitive function, and adverse events in the first 48 hours after surgery. Additionally, it will assess intraoperative hemodynamics and the length of hospital stay. By avoiding opioids, the trial seeks to minimize the undesirable side effects associated with opioid use.
Who should consider this trial
Good fit: Ideal candidates include adult patients scheduled for breast cancer surgery under general anesthesia.
Not a fit: Patients who are under 18, have chronic pain requiring opioids, or have severe comorbidities may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could significantly reduce opioid-related side effects and improve recovery outcomes for breast cancer surgery patients.
How similar studies have performed: There is growing interest and some preliminary success in opioid-sparing techniques, but this specific approach is still being evaluated.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * adult patients * breast cancer surgery (mastectomy, lumpectomy, with or without lymph node excision) under general anaesthesia Exclusion Criteria: * under 18 years * patient refusal * opioid use (systemic or not) for any reason (e.g., chronic malignant pain) * language barrier (difficulty in communicating in Greek language) * allergy to the administered agents * severe arrhythmia or other serious cardiac disease * severe liver and kidney failure * dementia, psychiatric diseases, and/or preoperative cognitive impairment
Where this trial is running
Ioannina, Epirus
- University Hospital of Ioannina — Ioannina, Epirus, Greece (Recruiting)
Study contacts
- Study coordinator: Agathi Karakosta
- Email: akarakosta@uoi.gr
- Phone: +306948066243
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.