Autonomic Nerve Blockade to Reduce Pain and Nausea After Bariatric Surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In this single-blind randomized trial, adults undergoing laparoscopic sleeve gastrectomy or gastric bypass are assigned to either the standard intraoperative care or an additional autonomic neural blockade (ANB) plus the usual abdominal wall block. The ANB uses local anesthetics, including Liposomal bupivacaine, to target nerves around the stomach and celiac area with the goal of reducing postoperative pain and nausea and the amount of opioid and antiemetic medications required. Outcomes focus on total postoperative opioid use (MMEs) and relief of pain and nausea over 72 hours. Surgeons know group assignment, but participants do not.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Individuals able and willing to consent and participate in all study activities
* Adults, ages 18-90
* All patients with severe obesity undergoing laparoscopic/robotic gastric bypass or sleeve gastrectomy

Exclusion Criteria:

* Patients taking opiates chronically
* Patients allergic to study medications
* Patients with any prior adverse reaction to ingredients included in the block
* Adults unable to consent
* Pregnant women
* Prisoners

Where it's running

• Endeavor Health
  Evanston, Illinois, United States Recruiting

Study contacts

• Principal investigator: Herbert Hedberg, MD — Endeavor Health
• Study coordinator: Herbert Hedberg, MD
• Email: herbert.hedberg@endeavorhealth.org
• Phone: 508-728-2106

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.