Comparing pain relief from two medications after knee surgery
Comparison Efficacy of Mirogabalin and Pregabalin in Total Knee Arthroplasty. a Randomized Controlled Trial
This study tests whether mirogabalin or pregabalin works better to relieve pain after knee surgery for people aged 50-85 with osteoarthritis.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 80 (estimated) |
| Ages | 50 Years to 85 Years |
| Sex | All |
| Sponsor | Thammasat University Hospital Academic / other |
| Locations | 1 site (Khlong Luang, Changwat Pathum Thani) |
| Trial ID | NCT06328062 on ClinicalTrials.gov |
What this trial studies
This clinical trial aims to compare the effectiveness of two medications, mirogabalin and pregabalin, in reducing postoperative pain following unilateral primary total knee arthroplasty (TKA). Participants aged 50-85 with osteoarthritis will be randomly assigned to receive either mirogabalin or pregabalin for six weeks post-surgery. The study will evaluate pain levels and functional outcomes to determine which medication provides better pain relief after the procedure.
Who should consider this trial
Good fit: Ideal candidates are individuals aged 50-85 who are undergoing unilateral primary total knee arthroplasty due to osteoarthritis.
Not a fit: Patients with a glomerular filtration rate below 60, severe liver disease, or those who have had previous knee surgery may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved pain management options for patients undergoing knee surgery.
How similar studies have performed: Previous studies have shown promising results in pain management with gabapentinoids, making this approach a potentially valuable addition to postoperative care.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Age 50-85 years old 2. Unilateral primary osteoarthritis undergoing primary TKA 3. ASA I-III Exclusion Criteria: 1. GFR \<60 2. Allergy to drug in this study 3. Cannot underwent spinal anesthesia and adductor canal block 4. Taking gabapentinoid within 3 months before surgery 5. History of previous knee surgery 6. Severe liver disease
Where this trial is running
Khlong Luang, Changwat Pathum Thani
- Thammasat University Hospital — Khlong Luang, Changwat Pathum Thani, Thailand (Recruiting)
Study contacts
- Study coordinator: Yot Tanariyakul, M.D.
- Email: y.tanariyakul@gmail.com
- Phone: +66863930257
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.