Comparing pain relief from two medications after knee surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial aims to compare the effectiveness of two medications, mirogabalin and pregabalin, in reducing postoperative pain following unilateral primary total knee arthroplasty (TKA). Participants aged 50-85 with osteoarthritis will be randomly assigned to receive either mirogabalin or pregabalin for six weeks post-surgery. The study will evaluate pain levels and functional outcomes to determine which medication provides better pain relief after the procedure.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age 50-85 years old
2. Unilateral primary osteoarthritis undergoing primary TKA
3. ASA I-III

Exclusion Criteria:

1. GFR \<60
2. Allergy to drug in this study
3. Cannot underwent spinal anesthesia and adductor canal block
4. Taking gabapentinoid within 3 months before surgery
5. History of previous knee surgery
6. Severe liver disease

Where it's running

• Thammasat University Hospital
  Khlong Luang, Changwat Pathum Thani, Thailand Recruiting

Study contacts

• Study coordinator: Yot Tanariyakul, M.D.
• Email: y.tanariyakul@gmail.com
• Phone: +66863930257

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.