Erector spinae plane block for managing pain after breast cancer surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of the erector spinae plane block (ESPB) combined with dexmedetomidine in reducing chronic postsurgical pain (CPSP) in breast cancer patients undergoing mastectomy. The study aims to determine if this nerve block technique can improve pain management and enhance the quality of life for patients post-surgery. Participants will be randomly assigned to receive either the ESPB intervention or standard care, with outcomes measured over time to assess pain levels and overall recovery. The trial builds on previous findings that suggest regional anesthesia may help prevent CPSP and improve long-term outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age of 18 years or over, but less than 85 years;
2. Scheduled to undergo mastectomy for primary unilateral breast cancer.

Exclusion Criteria:

1. Previous breast cancer surgery with an incision of \>2 cm;
2. Chronic opioid dependence or long-term intake of analgesic medicines (\>3 months);
3. Any contraindication to erector spinae plane block, including intrathoracic infection, infection at the puncture site, cancer invasion of the puncture site, severe spinal deformity, history of spinal surgery, and severe coagulopathy;
4. Inability to communicate in the preoperative period because of profound dementia, deafness, language barriers, or end-stage disease;
5. History of malignant tumor in other organs, or a current combination of malignant tumor of other organs;
6. History of coronary heart disease (diagnosed coronary stenosis, previous myocardial infarction, previous percutaneous coronary intervention or coronary artery bypass grafting); preoperative hepatic or renal impairment (alanine transaminase and/or aspartate transaminase ≥2 times of upper limit of normal, or serum creatinine\>133 µmol/L); history of peptic ulcer or hemorrhage; ASA classification IV or above;
7. Allergy to ropivacaine.

Where it's running

• Peking University First Hospital
  Beijing, Beijing Municipality, China Recruiting
• Beijing Cancer Hospital
  Beijing, Beijing Municipality, China Recruiting

Study contacts

• Principal investigator: Dong-Xin Wang, M.D., Ph.D. — Peking University First Hospital
• Study coordinator: Qiongfang Wu, M.D.
• Email: wuqf91@163.com
• Phone: +8618310161109

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.