Using intrathecal morphine to manage pain after lung surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effectiveness of intrathecal morphine for pain management in patients undergoing video-assisted thoracoscopic surgery (VATS). It is a randomized, placebo-controlled, double-blinded study where participants are assigned to receive either 5 mcg/kg of preservative-free intrathecal morphine or a placebo. The study aims to determine if morphine can reduce postoperative analgesic consumption and alleviate pain. Patients will be assessed for pain levels and medication use before discharge and through follow-up surveys at 1 and 3 months post-surgery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18-80 years old
* Undergoing elective video-assisted thoracoscopic or robotic assisted surgery for anatomical lung resection
* General anesthesia with anticipated intraoperative extubation.

Exclusion Criteria:

* American Society of Anesthesiologists (ASA) classification of 4 or 5
* Anticipated postoperative intubation
* Significant liver disease
* Preoperative use of intravenous inotropes and/or vasopressor support
* Preoperative mechanical ventilation
* Preoperative use of mechanical circulatory support device (intraaortic balloon pump, ventricular assist device, extracorporeal membrane oxygenation)
* Severe pulmonary disease (home oxygen requirement and/or current oral steroid use)
* Morphine allergy
* Opioid or alcohol abuse
* Chronic pain
* Renal failure
* Inability to comprehend English language
* Bleeding disorder
* Abnormal preoperative coagulation
* Infection
* Patient refusal
* Failed spinal

Where it's running

• University of Chicago
  Chicago, Illinois, United States Recruiting

Study contacts

• Study coordinator: Richa Dhawan, MD MPH
• Email: richa.dhawan@northwestern.edu
• Phone: 312-695-0061

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.