Condition
Inflammatory Bowel Diseases clinical trials and research
Research outlook What's coming for Ulcerative colitis: the next 6 months to 5 yearsAs of November 12, 2026, Find a Trial lists 81 Inflammatory Bowel Diseases clinical trials that are recruiting, at sites in 51 countries (most in United States (23), Canada (11), France (11)). By phase: Phase 2 (8), Phase 1 (3), Phase 3 (2), Phase 1/2 (1). The most active sponsors are Massachusetts General Hospital (3), Tanta University (2), Shanghai Institute of Acupuncture, Moxibustion and Meridian (2). There are also 10 NIH-funded research projects on Inflammatory Bowel Diseases, with $6.2 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 81Clinical trials
- 10NIH research projects
- 51Countries
Newest Inflammatory Bowel Diseases clinical trials
All recruiting trials (81)
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Long-Term Guselkumab Use in Adults with Inflammatory Bowel Disease
This study looks at how long adults with Crohn's disease or ulcerative colitis stay on guselkumab in real-world care.
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Intestinal ultrasound-guided management for inflammatory bowel disease
This study tests if adding point-of-care intestinal ultrasound at every visit changes treatment decisions for adults with Crohn’s disease or ulcerative colitis undergoing disease assessment.
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Resting energy use in kids with inflammatory bowel disease
This multicenter study will test the resting energy expenditure of children aged 6–17 with new IBD diagnoses to see how it relates to disease activity and treatment.
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Active video education by disease subtype to improve bowel prep before colonoscopy
We’re testing whether adding subtype-specific video education to standard prep improves bowel cleanliness in adults with IBD undergoing colonoscopy.
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Intestinal ultrasound to predict relapse in Crohn's disease patients in deep remission.
This project will try to see if a noninvasive transabdominal ultrasound can predict relapses in adults with Crohn's disease who are currently in deep remission.
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Ath-063: Testing a new treatment for moderately to severely active ulcerative colitis in patients who have tried other biologics
This study tests ATH-063 to see if it helps people with moderate to severe ulcerative colitis who did not respond to or relapsed after prior biologic therapy.
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Self-management program to improve health in inflammatory bowel disease
A digital self-management program is being tested to see if it helps people with inflammatory bowel disease feel better and manage their symptoms alongside standard care.
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Duloxetine to help mood and function in adults with inflammatory bowel disease
This trial tests whether duloxetine can help reduce anxiety, depression, and IBD-related disability in adults with inflammatory bowel disease.
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Lyophilized fecal microbiota transplant for adults with active ulcerative colitis
This trial will test whether a dried (lyophilized) fecal microbiota transplant helps adults with active ulcerative colitis when added to their current treatment or started alongside a new advanced medication.
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Pentoxifylline plus mesalamine for adults with mild-to-moderate ulcerative colitis
This study will test whether adding pentoxifylline to standard mesalamine helps adults with mild to moderate ulcerative colitis have fewer symptoms and less inflammation.
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Lower GI imaging with a tethered camera capsule
This test tries a small camera capsule on a string that takes pictures of the lower gut without sedation for adults who are healthy or who have Lynch syndrome, Crohn's disease, or other inflammatory bowel diseases.
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COMPARE — Newer IBD treatments in children
This project compares the safety and effectiveness of newer IBD medicines for children with Crohn's disease or ulcerative colitis who did not respond to anti‑TNF treatment.
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Wireless thermal capsule to detect gastrointestinal temperature changes
This study tests a swallowable wireless thermal capsule to see if it can collect temperature data from the GI tract in healthy adults.
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Long-acting antibody treatments alone and in combinations for moderate to severe ulcerative colitis
This tests long-acting antibody medicines, given after an IV induction and then as under-the-skin maintenance, to see if they help adults with moderate to severe ulcerative colitis.
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Examining the link between polyamine levels and inflammatory bowel disease progression
This study is trying to see if measuring certain substances in the body can help predict how inflammatory bowel diseases like Ulcerative Colitis and Crohn's Disease will progress in patients.
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Observational study comparing inflammatory markers in IBD and non-IBD participants
This study is trying to see how inflammation levels in people with Crohn's Disease and Ulcerative Colitis compare to those without these conditions when they start new treatments.
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Examining the NUDT15 gene's role in inflammatory bowel disease in Taiwan
This study looks at how the NUDT15 gene affects children with inflammatory bowel disease in Taiwan to see if it can help improve their treatment.
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Using advanced imaging to assess inflammation in bowel diseases
This study is testing if a new imaging technique can help doctors better see inflammation in patients with Inflammatory Bowel Disease compared to the standard method.
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Effects of phytocannabinoids on immune response in chronic inflammatory diseases
This study is testing whether phytocannabinoids like CBD and THC can help improve the immune response in people with chronic inflammatory diseases such as rheumatoid arthritis and inflammatory bowel disease.
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Examining Non-Alcoholic Fatty Liver Disease in Patients with Inflammatory Bowel Disease
This study looks at how common Non-Alcoholic Fatty Liver Disease is in people with Inflammatory Bowel Disease to see how gut health might affect liver health.
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Assessing gut microbiome's role in predicting inflammatory bowel disease progression
This study is trying to see if the types of bacteria in the gut can help predict how inflammatory bowel diseases like Crohn's disease and ulcerative colitis will progress in the first year after diagnosis.
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TQH3906 capsules for adults with moderate-to-severe ulcerative colitis or Crohn's disease
This trial will test whether taking TQH3906 capsules helps adults with moderate-to-severe ulcerative colitis or Crohn's disease control their symptoms over a 12-week treatment period.
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Endoscopic sleeve gastroplasty for obesity in patients with inflammatory bowel disease
This study is testing if a procedure called endoscopic sleeve gastroplasty can help people with obesity and inflammatory bowel disease improve their health and quality of life.
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Evaluating a new treatment for inflammatory bowel diseases using human intestinal models
This study is testing a new treatment for ulcerative colitis and Crohn's disease to see if it can help manage these conditions better.
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Evaluating robotic surgery for inflammatory bowel disease
This study is testing if robotic surgery can be a good option for adults with inflammatory bowel disease, like Crohn's or ulcerative colitis, compared to traditional surgery methods.
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Registry for Rare Diseases
This study is creating a detailed registry to collect information on rare diseases like amyloidosis and sarcoidosis to help improve how they are diagnosed and treated.
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BOOM-IBD2 Pivotal Neuromodulation for Ulcerative Colitis
This study tries a small device placed under the skin that sends mild signals to a nerve near the tailbone to reduce bowel urgency in adults with ulcerative colitis.
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Acupuncture to prevent Crohn's disease relapse
This study is testing if acupuncture can help people with Crohn's disease stay in remission longer by improving their body's energy and balance.
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How nutrition and body composition relate to outcomes in people with IBD
This study will see if nutrition and muscle mass affect outcomes in people with Crohn's disease or ulcerative colitis who are starting advanced medicines or having IBD-related surgery.
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Investigating gut bacteria's role in abdominal pain for IBD patients
This study is trying to see if certain gut bacteria are linked to ongoing abdominal pain in people with inflammatory bowel disease, even when their symptoms are under control.
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Using a device to analyze breath in patients with inflammatory bowel diseases
This study is testing a device that measures breath to see how diet affects symptoms and gas production in people with inflammatory bowel diseases and their family members.
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Coping skills program using heart rate biofeedback for youth with inflammatory bowel disease
This study is testing a new online program that helps teenagers with inflammatory bowel disease learn coping skills and manage their stress by using heart rate biofeedback.
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Predicting treatment outcomes for Crohn's disease using gut microbiome analysis
This study is trying to see if certain gut bacteria can help predict how well treatments will work for adults with Crohn's disease in British Columbia.
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Comparing two drugs and their combination for treating ulcerative colitis
This study is testing if using a combination of two drugs, infliximab and ustekinumab, can help adults with moderate to severe ulcerative colitis feel better compared to using each drug alone.
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Thalidomide treatment for very early onset inflammatory bowel disease
This study is testing if thalidomide can help young children with very early onset inflammatory bowel disease feel better and stay safe while using the medication.
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Impact of an anti-inflammatory diet on patients with inflammatory bowel disease
This study is testing whether an anti-inflammatory diet can help people with inflammatory bowel disease feel better and improve their quality of life.
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Research on gut inflammation in pediatric patients with inflammatory bowel diseases
This study is trying to learn more about gut inflammation in kids with inflammatory bowel diseases by collecting health information and samples from them and comparing it to kids who have different gut issues but no inflammation.
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Improving nutrition before surgery for patients with inflammatory bowel disease
This study tests if better nutrition before surgery can help people with inflammatory bowel disease recover faster and have fewer complications after their operation.
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Understanding muscle loss in patients with inflammatory bowel disease
This study looks at how muscle loss affects people with severe flare-ups of inflammatory bowel disease, comparing those who get medical treatment to those who have surgery, to see how their muscle health changes over a year.
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Investigating biomarkers for complications after colorectal surgery
This study is testing if certain blood markers can help predict complications after colorectal surgery and improve early cancer diagnosis for patients undergoing these procedures.
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Fecal Microbiota Transplant for Primary Sclerosing Cholangitis
This study is testing whether a stool transplant from healthy donors can help people with Primary Sclerosing Cholangitis feel better and improve their quality of life.
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Using fluconazole to enhance treatment response in Crohn's disease
This study is testing if adding fluconazole to IL-23 treatments can help people with Crohn's disease feel better.
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Cohort study of patients with Inflammatory Bowel Disease in Nantes
This study is trying to collect samples from patients with Inflammatory Bowel Disease to see if they can find new signs that help guide better treatments over the next year.
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Evaluating MORF-057 for treating active Crohn's disease in adults
This study is testing a new medication called MORF-057 to see if it can help adults with moderately to severely active Crohn's disease who haven't had enough relief from other treatments.
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Using virtual reality to treat pain in hospitalized patients with inflammatory bowel disease
This study tests if using virtual reality can help hospitalized patients with inflammatory bowel disease manage their pain better and feel more comfortable during their treatment.
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Testing infrared therapy for Crohn's disease
This study is testing if far infrared therapy can help people with Crohn's disease feel better compared to a placebo treatment.
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Switching to subcutaneous infliximab for IBD treatment
This study is testing if switching people with inflammatory bowel disease from an intravenous form of infliximab to a subcutaneous version, given weekly or bi-weekly, can lead to better health results.
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Evaluating inflammation in children with inflammatory bowel disease
This study is testing a new device to see how it can help doctors understand inflammation in children with Crohn's disease and ulcerative colitis, so they can provide better treatment.
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Analyzing genetic factors in inflammatory bowel disease across different populations
This study is trying to find out how genes and the environment affect inflammatory bowel disease by looking at samples from people with the condition and healthy individuals.
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Using statins to understand and treat Primary Sclerosing Cholangitis
This study is testing if the cholesterol-lowering drug rosuvastatin can help people with Primary Sclerosing Cholangitis by looking at how it affects their bile acids and gut bacteria.
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A cohort of patients with Inflammatory Bowel Disease undergoing treatment changes
This study is looking to see how treatment changes affect people with Inflammatory Bowel Disease over time to help create more personalized care plans.
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Peer mentoring program for managing psychological distress in IBD patients
This study tests whether a peer mentoring program can help adults with inflammatory bowel diseases feel better mentally during tough times like being newly diagnosed or facing surgery.
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Identifying Prognostic Factors in Inflammatory Bowel Disease
This study is trying to find out which signs and markers can help predict how inflammatory bowel disease will progress in people with Crohn's disease and ulcerative colitis.
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Comparing two surgical options for reconstructing the bowel after colectomy in ulcerative colitis patients
This study is testing which of two surgical options for rebuilding the bowel after colectomy works better for people with ulcerative colitis in terms of satisfaction and quality of life.
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Personalized dietary fiber recommendations for patients with inflammatory bowel disease
This study tests if personalized fiber diets can help children and young adults with inflammatory bowel disease feel better and improve their health.
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Using Metformin to Treat Ulcerative Colitis
This study is testing if adding Metformin to the treatment plan can help adults with mild to moderate ulcerative colitis feel better.
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Evaluating biomarkers in patients with moderate to severe ulcerative colitis receiving targeted therapies
This study is trying to find specific markers in blood, stool, and tissue that can help doctors choose the best targeted treatments for people with moderate to severe ulcerative colitis.
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Personalized Crohn's risk estimator (PRE-Crohn's) implementation and feasibility
This project will test a web-based personalized risk tool to see if giving unaffected first-degree relatives of people with Crohn's disease tailored risk information changes their behaviors and early disease markers.
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Collection of biological samples to study systemic autoimmune diseases
This study is collecting samples from people with autoimmune diseases like lupus and scleroderma to see if they can find new ways to diagnose and treat these conditions better.
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Evaluating Anorectal Function in Patients with Inflammatory Bowel Disease
This study is testing how well the muscles and nerves in the rectum work in people with inflammatory bowel disease to see if they have ongoing gut issues, even if they feel fine.
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Infusion of stem cells from umbilical cords for treating inflammatory bowel disease
This study is testing if infusing stem cells from umbilical cords can help people with severe inflammatory bowel disease feel better and improve their treatment options.
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Understanding Chronic Pain in Patients with Inflammatory Bowel Disease
This study is trying to find out what causes chronic abdominal pain in people who have just been diagnosed with inflammatory bowel disease, like ulcerative colitis and Crohn's disease.
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Restoring gut bacteria in patients with Crohn's disease
This study is testing whether a treatment using healthy gut bacteria can help people with active Crohn's disease feel better.
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Environmental exposure to DON and its possible role in Crohn's disease
This study will test whether exposure to the food contaminant DON affects gut exposure, metabolism, and harm in people with ileocolic Crohn's disease compared with people having similar bowel surgery for other reasons.
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Evaluating Mirikizumab for Children with Ulcerative Colitis or Crohn's Disease
This study is testing if a medication called mirikizumab can help children with ulcerative colitis or Crohn's disease feel better over a long period of time.
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Registry and biorepository for patients with inflammatory bowel diseases in Central Texas
This study is trying to create a database and collection of samples from people with inflammatory bowel diseases like Crohn's and ulcerative colitis to help future research on these conditions.
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Diet with fermented foods for patients with Ulcerative Colitis
This study is testing if adding fermented foods to the diet can help people with mild to moderate Ulcerative Colitis feel better and reduce inflammation.
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Investigating immune-related intestinal diseases in adults
This study looks at how certain immune-related gut diseases in adults affect the balance of cells in the intestines and liver to see if it can lead to serious complications.
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Understanding chronic inflammatory systemic diseases and their treatments
This study looks at patients with chronic inflammatory diseases to see how these conditions are related and how they can be treated better.
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Acupuncture for treating mild to moderate Crohn's disease
This study is testing whether acupuncture can help people with mild to moderate Crohn's disease feel better by looking at their symptoms and brain activity.
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Collecting samples from patients with colorectal and gastric cancers and non-malignant diseases
This study is collecting blood and tissue samples from patients with colorectal and gastric cancers, as well as non-cancerous gastrointestinal diseases, to help with future research.
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Vagal nerve stimulation for autoimmune and gastrointestinal conditions
This study is testing if vagal nerve stimulation can improve immune and gut health in patients getting the treatment for epilepsy.
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Safety of IBD medications during pregnancy and breastfeeding
This study looks at how safe IBD medications are for pregnant women and their babies by comparing outcomes for children whose mothers took these drugs during pregnancy to those who didn’t.
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Investigating gut microbiota and genetics in inflammatory bowel diseases
This study is trying to understand how gut bacteria and genetics affect inflammatory bowel diseases like ulcerative colitis and Crohn's disease, to help improve treatment for patients.
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Observational research on chronic diseases and healthcare analytics
This study looks at health records to see how well different treatments work for chronic diseases like HIV and hepatitis, aiming to improve patient care and support.
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Identifying biomarkers in inflammatory bowel disease
This study is trying to find specific markers in people with Crohn's disease and ulcerative colitis that can help predict how their disease will progress and how well they will respond to new treatments.
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Registry for Fecal Microbiota Transplantation in Inflammatory Bowel Diseases
This study is tracking people with inflammatory bowel diseases who are getting fecal microbiota transplants to see how changing their gut bacteria might help their symptoms and overall health.
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Exploring gut microbiome in patients with inflammatory bowel disease
This study is trying to understand the gut bacteria in Korean patients with inflammatory bowel diseases to see how these bacteria might relate to their health and genetics.
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Observing the safety and effectiveness of treatments for children with inflammatory bowel disease
This study looks at how safe and effective current treatments are for children under 18 with inflammatory bowel disease to help understand their outcomes and any risks involved.
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Understanding Inflammatory Bowel Disease in Canadian Children
This study looks at why more kids in Canada are getting Inflammatory Bowel Disease and tries to find out how things like environment and genetics affect their health and treatment.
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Studying how genetic testing can improve medication use in patients
This study is trying to see if using genetic testing can help doctors choose the right medications for patients with heart diseases, inflammatory bowel diseases, and autoimmune diseases to improve their treatment outcomes.
NIH-funded research (10)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Comparative care for IBD in Hispanic patients
A Mayo Clinic Arizona team will study how Crohn’s disease and ulcerative colitis progress and respond to treatments in Hispanic patients using real-world data.
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Understanding why some people with inflammatory bowel disease fail therapy
A physician-scientist at UNC is pursuing why inflammatory bowel disease treatment stops working so therapies can be kept effective longer.
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Celiac and IBD: unlocking how genes influence disease with DNA methylation
A research project aims to use genetic and epigenetic clues to better understand why celiac disease and inflammatory bowel disease affect people differently and how they respond to treatment.
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How genes and DNA changes influence celiac disease and inflammatory bowel disease
This project looks for DNA changes that alter gene activity to help predict risk, severity, and treatment response for people with celiac disease and inflammatory bowel disease.
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Understanding what triggers inflammation in inflammatory bowel diseases
This study is looking at what causes inflammation in people with Crohn's disease and ulcerative colitis who are feeling really well, to help find ways to keep them healthy and prevent flare-ups in the future.
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Finding ways to block bacterial enzymes that worsen inflammatory bowel diseases
This project looks for new ways to treat inflammatory bowel diseases like Crohn's and ulcerative colitis by targeting specific enzymes made by gut bacteria.
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Using nanoparticles to deliver epigenetic treatments for inflammatory bowel diseases
This study is exploring a new way to treat inflammatory bowel diseases like ulcerative colitis and Crohn's disease by using tiny particles to deliver special medicines that can help reduce inflammation in your colon, aiming for a treatment that works better and has fewer side effects.
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Understanding treatment outcomes in Hispanic patients with inflammatory bowel diseases
This study looks at how well treatments work for Hispanic patients with inflammatory bowel diseases like Crohn’s and ulcerative colitis, and it aims to understand how social factors and biology affect their health outcomes.
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Targeting bacterial proteins to treat inflammatory bowel diseases
This study is looking at how certain bacteria in the gut might affect inflammation and the protective barrier in people with inflammatory bowel diseases like Crohn's and ulcerative colitis, with the hope of finding new ways to help ease their symptoms.
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Understanding genetic factors in celiac disease and inflammatory bowel diseases
This study is looking at how our genes affect celiac disease and inflammatory bowel diseases like ulcerative colitis and Crohn's disease, so we can better understand how to tailor treatments for patients based on their unique genetic makeup.
Related topics
Quick answers
How many Inflammatory Bowel Diseases clinical trials are recruiting right now?
81, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 51 countries. The most sites are in United States (23 trials), Canada (11 trials), France (11 trials), China (9 trials), United Kingdom (8 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 8, Phase 1: 3, Phase 3: 2, Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.