Condition

Autoimmune Diseases clinical trials and research

• 72Clinical trials
• 36NIH research projects
• 1New in 30 days
• 20Countries

Newest Autoimmune Diseases clinical trials

All recruiting trials (72)

• ETHY-001 safety and activity in Thyroid Eye Disease (TED)

  This study tests ETHY-001 versus placebo to see if it is safe, tolerable, and shows activity in people with thyroid eye disease.

  Recruiting at 2 sites Phase 1 Ethyreal Bio, Inc. · Orland Park, Illinois and 2 other locations · NCT07885605

• CR-402 treatment for refractory autoimmune disease

  This study tests CRT-402, a CD19-targeted CAR-T therapy, in adults with active, treatment-resistant autoimmune diseases like SLE, systemic sclerosis, and inflammatory myopathy to see if it is safe and capable of helping control disease.

  Recruiting Phase 1/2 Myeloid Therapeutics · Nedlands, Western Australia · NCT07778446

• Music-4-MS: A 12-week music-based program to support thinking skills in people with MS

  A 12-week music-based program is tested to see if it helps cognitive function and mood in people living with multiple sclerosis.

  Recruiting University of Texas at Austin · Austin, Texas · NCT07759115

• ATG-201 in adults with autoimmune diseases

  This early, open-label study tests ATG-201 in adults with autoimmune diseases to see if it is safe and tolerable, and to get initial clues about how the body handles the drug and its effects.

  Recruiting Phase 1 Antengene Corporation · Bengbu, Anhui and 21 other locations · NCT07732309

• AMX0035 in adults with Type 1 Diabetes

  This study tests whether 24 weeks of the oral medication AMX0035 help improves metabolic health in adults with Type 1 Diabetes compared with a placebo.

  Recruiting Phase 2 University of Washington · Seattle, Washington and 1 other locations · NCT07699380

• CD19/BCMA UCART for B cell–related autoimmune diseases

  This early-stage study tests QT-219CX, a universal allogeneic CAR-T cell therapy that targets CD19 and BCMA, in people with refractory B-cell–related autoimmune diseases to see if it can be given safely and provide early signs of benefit.

  Recruiting Early Phase 1 The Children's Hospital of Zhejiang University School of Medicine · Hangzhou, Zhejiang · NCT07586267

• Ath-063: Testing a new treatment for moderately to severely active ulcerative colitis in patients who have tried other biologics

  This study tests ATH-063 to see if it helps people with moderate to severe ulcerative colitis who did not respond to or relapsed after prior biologic therapy.

  Recruiting at 4 sites Phase 2 Athos Therapeutics Inc · Miami, Florida and 3 other locations · NCT07513181

• Allogeneic CD19/BCMA CAR‑T for B‑cell autoimmune disease

  This Phase 1 study will test a donor-derived CAR‑T therapy that targets CD19 and BCMA to try to reset the immune system in people with refractory B‑cell autoimmune diseases such as SLE, IgA nephropathy, systemic sclerosis, and resistant nephrotic syndrome.

  Recruiting Early Phase 1 The Children's Hospital of Zhejiang University School of Medicine · Hangzhou, Zhejiang · NCT07507201

• CD19/BCMA CAR-T therapy for refractory autoimmune diseases

  This study tests a CD19/BCMA CAR-T treatment in adults with difficult-to-treat autoimmune diseases to see if it is safe and may help control their disease.

  Recruiting at 2 sites Wuhan Integrated Traditional Chinese and Western Medicine Hospital · Wuhan, Hubei and 2 other locations · NCT07490951

• S-4321 in adults with autoimmune or immune-mediated diseases

  This study tests S-4321 in adults with autoimmune conditions to see if it is safe and tolerable and to gather early data on how the drug behaves in the body and its initial effects on disease markers.

  Recruiting at 2 sites Phase 1 Seismic Therapeutic AU Pty Ltd · Charlestown, New South Wales and 1 other locations · NCT07455578

• AFN50 injection for relapsing or treatment‑resistant systemic lupus erythematosus

  AFN50 injections will be tried to see if they are safe and reduce disease activity in adults with relapsing or treatment‑resistant systemic lupus erythematosus.

  Recruiting Early Phase 1 AlphaNa Bioscience Company Limited · Hefei, Anhui · NCT07408336

• Children's immune response to small amounts of gluten

  This study tests whether giving small, controlled amounts of gluten to children with celiac disease causes measurable changes in their immune cells.

  Recruiting Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud · Málaga · NCT07362654

• Insulin delivery technology and eating behaviours in people with type 1 diabetes

  This project will test whether automated insulin delivery systems change eating behaviours and make carbohydrate counting easier for people aged 12 and older who have type 1 diabetes in Canada.

  Recruiting McGill University · Montreal, Quebec · NCT07348432

• Allogeneic CAR T cells targeting CD19 and BCMA for B‑cell autoimmune diseases

  This study will try a single infusion of off‑the‑shelf CAR T cells that target CD19 and BCMA to treat people with B‑cell–mediated autoimmune diseases such as lupus, IgA nephropathy, and drug‑resistant nephrotic syndrome.

  Recruiting Phase 1 The Children's Hospital of Zhejiang University School of Medicine · Hangzhou, Zhejiang · NCT07305116

• Second-generation CD19/BCMA CAR‑NK cell treatment for children with B cell autoimmune disease

  This study will try a new CAR‑NK cell therapy that targets CD19 and BCMA in children with B cell–driven autoimmune diseases to see if it is safe and reduces disease activity.

  Recruiting Early Phase 1 The Children's Hospital of Zhejiang University School of Medicine · Hangzhou, Zhejiang · NCT07283315

• Anti-CD19/BCMA U CAR-T cell therapy for relapsed or refractory autoimmune diseases

  This pilot will test whether anti-CD19/BCMA U CAR-T cells can help adults with relapsed or refractory autoimmune diseases such as SLE, systemic sclerosis, Sjögren's syndrome, and rheumatoid arthritis.

  Recruiting Early Phase 1 Changhai Hospital · Shanghai · NCT07246096

• Long-term outcomes for people with immune TTP in the French national TMA cohort

  This project uses past medical records to see long-term health outcomes and complications in people in France who had immune thrombotic thrombocytopenic purpura (iTTP).

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07205861

• Safety testing of STR-P004 in adults with relapsed or refractory autoimmune diseases

  This study will try multiple doses of STR-P004 to see if it's safe, tolerated, and how it behaves in adults whose autoimmune disease has relapsed or not responded to treatment.

  Recruiting Beijing GoBroad Hospital · Beijing · NCT07143617

• GT719 injection for adults with moderate to severe refractory autoimmune diseases

  This trial will try giving GT719 injections to 10 adults with moderate to severe autoimmune diseases that haven't responded to standard treatments to see if the treatment is safe and helps control their disease.

  Recruiting Early Phase 1 Grit Biotechnology · Shanghai · NCT07122076

• One-time anti-CD19/BCMA CAR gene therapy for refractory autoimmune diseases

  This study will try a one-time intravenous anti-CD19/BCMA CAR gene therapy to see if it helps adults whose autoimmune disease has not responded to standard treatments.

  Recruiting Anhui Provincial Hospital · Hefei, Anhui · NCT07121777

• CD19 CAR-T (JY231) for hard-to-treat autoimmune diseases

  This project will try a CD19 CAR-T treatment called JY231 in adults whose autoimmune diseases haven't improved with standard therapies.

  Recruiting Shenzhen Genocury Biotech Co., Ltd. · Wuhan, Hubei · NCT07059169

• BCMA- and CD19-directed CAR-T therapy for refractory autoimmune diseases

  This treatment will try BCMA- and CD19-targeted CAR-T cells in adults whose autoimmune disease hasn't responded to standard therapies.

  Recruiting Anhui Provincial Hospital · Hefei · NCT07052565

• Natural history of type I interferonopathies in a European patient group

  This project will follow people with genetically confirmed type I interferonopathies across European centers to see how the disease develops and which clinical and blood markers track disease activity.

  Recruiting at 18 sites Imagine Institute · Innsbruck and 31 other locations · NCT07040774

• Using Acthar Gel to treat moderate-severe keratitis in autoimmune patients

  This study is testing if Acthar Gel can help people with autoimmune diseases and dry eye feel less eye pain and improve their eye health over 12 weeks.

  Recruiting Phase 4 Toyos Clinic · Nashville, Tennessee · NCT06964269

• Understanding genetic factors in autoimmune diseases in Peru

  This study is looking to see how genetic differences affect autoimmune diseases in people from Peru to better understand their health needs.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland and 1 other locations · NCT06948110

• Research on factors predicting IVF outcomes in women with autoimmune diseases

  This study is trying to find out what factors can help predict how well in vitro fertilization (IVF) works for women with autoimmune diseases.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia, Pavia · NCT06872294

• Using CAR-NK cells to treat autoimmune diseases like lupus and nephrotic syndrome

  This study is testing a new treatment using CAR-NK cells to see if it can help people with autoimmune diseases like lupus and nephrotic syndrome feel better.

  Recruiting Early Phase 1 The Children's Hospital of Zhejiang University School of Medicine · Hangzhou, Zhejiang · NCT06792799

• mRNA (ABO2203) that delivers a CD19/CD3 T‑cell engager for people with refractory autoimmune diseases

  This trial will test whether an mRNA injection called ABO2203, which produces a CD19/CD3 T‑cell engager, is safe and helpful for adults whose autoimmune disease did not respond to standard treatments.

  Recruiting at 2 sites Early Phase 1 Ruijin Hospital · Wuhan, Hubei and 2 other locations · NCT06747156

• Testing the safety of DWP212525 in healthy men

  This study is testing the safety of a new drug called DWP212525 in healthy men to see how well they can tolerate different doses.

  Recruiting Phase 1 Daewoong Pharmaceutical Co. LTD. · Seoul · NCT06736587

• Using CD19 CAR T cells to treat difficult autoimmune diseases

  This study is testing if a new treatment using CD19 CAR T cells can help people with tough autoimmune diseases like lupus feel better.

  Recruiting Phase 1/2 Beijing GoBroad Hospital · Beijing, Beijing Municipality · NCT06688799

• CD19 CAR-T for relapsed or treatment-resistant autoimmune diseases

  This trial will test whether a patient's own CD19 CAR-T cells can help adults with relapsed or refractory autoimmune diseases like SLE, systemic sclerosis, ANCA-associated vasculitis, inflammatory myopathies, or Sjögren's syndrome.

  Recruiting Early Phase 1 Institute of Hematology & Blood Diseases Hospital, China · Tianjin, Tianjin Municipality · NCT06680388

• Treatment of generalized myasthenia gravis with a new CAR-T therapy

  This study is testing a new CAR-T therapy to see if it can safely help adults with generalized myasthenia gravis feel better.

  Recruiting at 14 sites Phase 1 Gilead Sciences · Los Angeles, California and 13 other locations · NCT06626919

• Investigating the safety and effectiveness of porcine pancreatic cells in patients with Type 1 diabetes

  This study is testing if using pig pancreas cells can help adults with tough-to-manage Type 1 diabetes feel better and avoid dangerous low blood sugar episodes.

  Recruiting Phase 1/2 Otsuka Pharmaceutical Factory, Inc. · Chicago, Illinois · NCT06575426

• Targeted CAR-T therapy for autoimmune diseases

  This study is testing a new type of CAR-T therapy to see if it can help people with active autoimmune diseases feel better and manage their symptoms.

  Recruiting Early Phase 1 Nanjing Bioheng Biotech Co., Ltd. · Bengbu, Anhui · NCT06548607

• Exploring a new treatment for difficult autoimmune diseases

  This study is testing a new one-time injection treatment for people with tough autoimmune diseases to see if it can help them feel better when other treatments haven't worked.

  Recruiting The First Affiliated Hospital of University of Science and Technology of China · Changsha, Hunan · NCT06503224

• Identifying biomarkers for autoimmune diseases affecting the nervous system

  This study is trying to find specific markers in the blood of people with autoimmune diseases affecting the nervous system, like Multiple Sclerosis, to help with early diagnosis and better treatment options.

  Recruiting Tongji Hospital · Wuhan · NCT06502015

• Preventive treatment for pneumonia in patients with autoimmune diseases

  This study is testing if a common antibiotic can help prevent a specific type of pneumonia in people with autoimmune diseases.

  Recruiting Phase 4 Tongji Hospital · Wuhan, Hubei · NCT06499233

• Improving COVID-19 vaccine uptake in Black and Latinx patients with rheumatologic diseases

  This study is testing a new approach to help Black and Latinx patients with autoimmune diseases get updated COVID-19 vaccines by providing them with helpful information and support.

  Recruiting at 4 sites University of Alabama at Birmingham · Birmingham, Alabama and 3 other locations · NCT06469788

• CD19 CAR NK cell injection for treating autoimmune diseases

  This study is testing if CD19 CAR NK cell injections can safely help people with tough autoimmune diseases feel better.

  Recruiting Phase 1 Changhai Hospital · Shanghai · NCT06464679

• Collection of biological samples for rare pediatric autoimmune and autoinflammatory diseases

  This study is collecting blood and tissue samples from kids with rare autoimmune diseases to help researchers learn more about these conditions and improve diagnosis.

  Recruiting at 4 sites Hospices Civils de Lyon · Bron, Bron and 12 other locations · NCT06435468

• CAR-T cell therapy targeting specific markers in autoimmune diseases

  This study is testing a new CAR-T cell therapy to see if it can help people with tough autoimmune diseases like lupus and Sjogren's syndrome feel better.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT06428188

• Immune signals and regulatory T cells in migraine

  This research will test whether blood immune markers and regulatory T cells are linked to migraine in women ages 18–50 who have migraine or certain autoimmune/inflammatory conditions.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand, AURA · NCT06426316

• Registry for pediatric autoimmune and autoinflammatory diseases in China

  This study collects information from children in China with autoimmune and autoinflammatory diseases to better understand their conditions and improve treatment options.

  Recruiting at 9 sites Peking Union Medical College Hospital · Beijing, Beijing Municipality and 8 other locations · NCT06417502

• Using a new plasma filter for blood purification in autoimmune diseases

  This study is testing a new plasma filter to see if it can improve blood purification treatments for people with autoimmune diseases.

  Recruiting at 7 sites Fresenius Medical Care Deutschland GmbH · Aschaffenburg, Bavaria and 6 other locations · NCT06382675

• Study on how diet affects autoimmune diseases in rheumatology patients

  This study looks at how changing to a healthier diet, like the Mediterranean diet, might help people with autoimmune diseases feel better and manage their symptoms.

  Recruiting University of Central Florida · Orlando, Florida · NCT06339957

• Using CAR NK cells to treat autoimmune diseases

  This study is testing a new treatment using special immune cells to see if it can help people with tough autoimmune diseases related to B-cells feel better.

  Recruiting at 2 sites Early Phase 1 Affiliated Hospital of Jiangsu University · Zhenjiang, Jiangsu and 1 other locations · NCT06318533

• Registry for systemic treatments of alopecia areata

  This study is trying to see how well different systemic treatments work for people with moderate-to-severe alopecia areata, alopecia totalis, and alopecia universalis.

  Recruiting Erasmus Medical Center · Rotterdam · NCT06283316

• CD19-BAFF CAR-T cell therapy for autoimmune diseases

  This study is testing a new CAR-T cell therapy for people with tough autoimmune diseases who haven't found relief from standard treatments to see if it can help them feel better.

  Recruiting Early Phase 1 Zhejiang University · Hangzhou, Zhejiang · NCT06279923

• Understanding X-linked Moesin Associated Immunodeficiency

  This study looks at how to better treat boys with X-linked Moesin Associated Immunodeficiency by collecting health information to understand their infections and the effects of their genetic mutations.

  Recruiting at 2 sites Institut National de la Santé Et de la Recherche Médicale, France · Bethesda, Maryland and 9 other locations · NCT06278337

• Analyzing immune system issues in patients

  This study is trying to collect blood and stool samples from people with immune system problems and healthy individuals to better understand these issues and help improve treatments.

  Recruiting Karolinska Institutet · Stockholm · NCT06248957

• Characterizing genetic diseases affecting the immune and neurological systems

  This study is trying to learn more about rare genetic diseases that affect the immune and nervous systems to help find better ways to diagnose and treat them.

  Recruiting Imagine Institute · Paris, Île-de-France Region · NCT06235580

• Using the 'Support' online training and peer program for adults with type 1 diabetes

  This project will test whether adults with type 1 diabetes who get access to the online 'Support' training and peer platform through their diabetes clinic manage their diabetes better than those who use the platform on their own.

  Recruiting at 4 sites McGill University · Montreal, Quebec and 3 other locations · NCT06069583

• Registry for evaluating a comprehensive approach to autoimmune disorders

  This study is testing a personalized treatment program for people with autoimmune disorders to see if combining different therapies helps them feel better over time.

  Recruiting AndHealth · Columbus, Ohio · NCT05883371

• Preserving ovarian tissue for future fertility in women facing cancer or autoimmune diseases

  This study is testing a way to preserve ovarian tissue for women facing cancer or autoimmune diseases so they can have children in the future, even if they can't use regular methods like freezing eggs.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT05875155

• Prednisone plus iguratimod versus prednisone plus leflunomide for IgG4‑RD with superficial organ involvement

  This 12‑month trial will test whether adding iguratimod or leflunomide to prednisone better prevents relapse in people with IgG4‑related disease affecting superficial organs.

  Recruiting Peking Union Medical College Hospital · Beijing · NCT05789030

• Profiling blood biomarkers in patients with systemic inflammatory diseases

  This study is testing how different blood markers change over time in people with systemic inflammatory diseases to improve diagnosis and treatment options.

  Recruiting at 4 sites University Hospital, Ghent · Antwerp and 6 other locations · NCT05670301

• Analysis of glycosylation in lupus anti-DNA antibodies

  This study looks at how certain sugars on antibodies in people with lupus might change over time and how those changes relate to their disease activity.

  Recruiting at 2 sites University Hospital, Montpellier · Montpellier and 1 other locations · NCT05394922

• Identifying biomarkers in autoimmune and inflammatory diseases

  This study is trying to find specific markers in the blood of people with autoimmune diseases to help tailor their treatment and track how well it works.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris, France · NCT05383339

• Collecting data on immune-related side effects in cancer treatment

  This study is trying to collect information and samples from cancer patients using immune treatments to see what causes side effects and how to better manage them.

  Recruiting Sir Mortimer B. Davis - Jewish General Hospital · Montreal, Quebec · NCT05139706

• Examining STIM1 Protein Levels in Autoimmune Disease Patients

  This study is testing the levels of a protein called STIM1 in blood cells from people with autoimmune diseases to see if it could help understand these conditions better.

  Recruiting at 4 sites University Hospital, Brest · Brest, Brest and 3 other locations · NCT04978948

• Using brain stimulation to help COVID-19 patients with autoimmune diseases

  This study is testing if a type of brain stimulation can help COVID-19 patients with autoimmune diseases feel better by reducing their fatigue and pain.

  Recruiting University of Sao Paulo · São Paulo · NCT04890483

• Investigating white blood cells to develop new therapies for autoimmune diseases

  This study is trying to learn more about white blood cells from volunteers to help create new treatments for autoimmune diseases.

  Recruiting Quell Therapeutics Limited · London · NCT04838171

• A platform for collecting health data on ME/CFS and Long Covid

  This study is trying to collect health information from adults with ME/CFS and Long Covid to help researchers better understand these conditions and improve future treatments.

  Recruiting Brain Inflammation Collaborative · Delafield, Wisconsin · NCT04806620

• Biorepository for patients receiving biologic therapy at Mount Sinai

  This study is collecting health information from patients receiving biologic therapy at Mount Sinai to help improve treatments for various immune-related diseases.

  Recruiting Icahn School of Medicine at Mount Sinai · New York, New York · NCT04784364

• Using stem cells to treat various chronic and acute health conditions

  This study is testing if stem cell therapy can help people with different long-term and short-term health issues, like autoimmune diseases and heart problems, feel better and improve their quality of life.

  Recruiting Phase 1/2 Thomas Advanced Medical LLC · Culver City, California · NCT04684602

• Sparsentan for IgA Nephropathy: safety and activity in adults with incident IgAN and recurrent IgAN after transplant

  This trial tests whether sparsentan can be safely given and help kidney outcomes in adults with immunoglobulin A nephropathy, including people newly diagnosed who haven’t had ACEI/ARB therapy and people with recurrent IgAN after kidney transplant.

  Recruiting at 6 sites Phase 2 University of Leicester · Cambridge, England and 5 other locations · NCT04663204

• Using CT103A cells to treat autoimmune diseases of the nervous system

  This study is testing if a new treatment using CT103A cells can help people with certain autoimmune diseases affecting the nervous system feel better.

  Recruiting Early Phase 1 Tongji Hospital · Wuhan, Hubei · NCT04561557

• Real-time continuous glucose monitoring for young adults at risk of DKA

  This project will try a Dexcom G6 real-time continuous glucose monitor to see if it helps 18-25-year-olds with insulin-treated diabetes who have poor blood sugar control or recent hospital admissions for high blood sugar.

  Recruiting Imperial College London · London · NCT04039763

• Vagal nerve stimulation for autoimmune and gastrointestinal conditions

  This study is testing if vagal nerve stimulation can improve immune and gut health in patients getting the treatment for epilepsy.

  Recruiting at 2 sites University of Louisville · Louisville, Kentucky and 3 other locations · NCT03953768

• Collection and distribution of biospecimens for research purposes

  This study is trying to see how collecting samples from healthy people and those with medical conditions can help researchers find new ways to diagnose and treat diseases.

  Recruiting iSpecimen Inc · Huntsville, Alabama and 1 other locations · NCT03848962

• Registry for pregnant women with autoimmune diseases

  This study is trying to learn more about how autoimmune diseases affect pregnant women and their babies to help improve their health during and after pregnancy.

  Recruiting Duke University · Durham, North Carolina · NCT03276923

• Access and distribution of unlicensed cryopreserved cord blood units

  This study is testing how well unlicensed frozen cord blood units work for helping both kids and adults with blood cancers recover after a transplant.

  Recruiting at 113 sites Center for International Blood and Marrow Transplant Research · Birmingham, Alabama and 141 other locations · NCT01351545

NIH-funded research (36)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Unified and fair multimodal learning for autoimmune diseases

  A patient-friendly AI approach will combine many kinds of health data to improve diagnosis and personalized care for autoimmune diseases, including lupus.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11625649

• Fair combined medical-data models for autoimmune diseases

  A new computer model will learn from medical records, tests, scans, genetics, and wearable data to help spot autoimmune diseases earlier in people with symptoms or at higher risk.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11401314

• Non-immunosuppressive, targeted immune therapies for autoimmune diseases

  Aims to develop targeted treatments that selectively remove disease-causing B cells in autoimmune conditions like pemphigus vulgaris without broadly weakening the immune system.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11367436

• Home-based monitoring of environmental exposures and biology for autoimmune diseases

  This project develops ways for people with autoimmune conditions to collect environmental and biological data at home so researchers can link exposures to health changes over time.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11363408

• Targeting a specific prolactin receptor form to help people with autoimmune diseases and B-cell cancers

  A scientist is testing a new approach that targets a particular prolactin receptor to potentially treat autoimmune diseases and certain B-cell cancers.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11362689

• Understanding B cell Behavior in SLE and Other Autoimmune Diseases

  Researchers are studying how B cells and their epigenetic marks behave in people with autoimmune diseases like SLE to find new ways to treat these conditions.

  NIH research Emory University · Atlanta, United States · NIH-11332689

• Regulation of B cell Responses in SLE and Other Autoimmune Diseases

  A largescale NIH grant is studying how specific B cell types drive autoimmune diseases like lupus, with the aim of improving treatments for people affected by these conditions.

  NIH research Emory University · Atlanta, United States · NIH-11332684

• Regulation of B cells in autoimmune diseases

  A patient-facing overview of a large NIH project that supports collaborations and clinical projects to study B cells in autoimmune diseases.

  NIH research Emory University · Atlanta, United States · NIH-11332683

• Regulation of B cell responses in lupus and autoimmune diseases

  A program funded by NIH to understand how B cells contribute to lupus and related autoimmune diseases, with collaboration through Emory University.

  NIH research Emory University · Atlanta, United States · NIH-11332681

• Understanding B cell Roles in autoimmune diseases like lupus

  Doctors are studying how B cells go wrong in autoimmune diseases to develop better, more precise treatments.

  NIH research Emory University · Atlanta, United States · NIH-11332680

• A probiotic pill that delivers an immune‑calming peptide for autoimmune conditions

  This project tests an engineered probiotic that makes a small peptide to calm overactive T cells in people with autoimmune diseases such as rheumatoid arthritis.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11321519

• Precision CAR-NK therapy to selectively remove autoreactive B cells in autoimmune diseases

  A new, targeted cell therapy aims to remove disease-causing B cells in lupus while preserving the rest of the immune system.

  NIH research Celdara Medical, LLC · Lebanon, United States · NIH-11315692

• Cell- and tissue-level maps for autoimmune diseases

  We use advanced single-cell and spatial genomic tests on samples from people with rheumatoid arthritis, psoriasis, psoriatic arthritis, Sjögren’s syndrome, or lupus to locate the cells and molecules driving these conditions.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11306983

• Using GABA to control immune inflammation in autoimmune and allergic diseases

  This research looks at whether changing how immune cells use the natural chemical GABA can lower harmful inflammation in autoimmune and allergic diseases.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11290423

• Mapping immune cells and tissue changes in autoimmune diseases

  Using advanced lab methods to identify the immune cell types and molecular signals driving conditions like rheumatoid arthritis, lupus, psoriatic diseases, and Sjögren's.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11286638

• How immune antibodies attack nerve receptors called cys-loop receptors

  Researchers will use antibodies from patients with conditions like myasthenia gravis and autoimmune encephalitis to map how those antibodies bind and block nerve receptors.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11248361

• Macrophages and inflammation in autoimmune arthritis

  This project looks at how macrophages (a type of immune cell) become 'trained' to produce inflammatory signals in people with autoimmune arthritis so better treatments can be developed.

  NIH research Hospital for Special Surgery · New York, UNITED STATES · NIH-11239974

• New Immune Therapies for Autoimmune Diseases

  This project aims to create new, focused immune treatments for autoimmune diseases like Pemphigus Vulgaris, without broadly suppressing the immune system.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-11140314

• Understanding a hormone receptor to help treat autoimmune diseases and B-cell cancers

  This work explores how a specific hormone receptor contributes to certain autoimmune diseases and B-cell cancers, hoping to find new ways to help patients.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11132888

• Developing advanced methods to improve diagnosis of autoimmune diseases

  This study is working on a new way to help doctors diagnose autoimmune diseases like lupus more accurately and quickly, especially for Black and Hispanic women who are often affected more, by using different types of health information together.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11091113

• Developing a new treatment for immune thrombocytopenia using a specialized enzyme

  This study is testing a new treatment for people with immune thrombocytopenia (ITP) that uses a specially designed enzyme to help reduce harmful antibodies and improve platelet counts, aiming to provide a safer and more effective option than what’s currently available.

  NIH research Cyrus Biotechnology, INC. · Seattle, United States · NIH-11069861

• Understanding immune responses in autoimmune diseases

  This study is all about gathering and sharing information on how our immune system reacts in autoimmune diseases like lupus and rheumatoid arthritis, so that patients can benefit from better understanding and treatment options.

  NIH research La Jolla Institute for Immunology · La Jolla, United States · NIH-11041926

• Understanding how genetic variants affect gene expression in autoimmune diseases

  This study is looking at how certain genes in immune cells might affect autoimmune diseases like ankylosing spondylitis, with the goal of finding better treatments for patients by understanding which genes are involved.

  NIH research University of Washington · Seattle, United States · NIH-11032617

• Using engineered probiotics to treat autoimmune diseases

  This study is exploring a new way to help people with autoimmune diseases by using a special probiotic that can be taken by mouth, which delivers helpful proteins to calm down the immune system, making treatment easier and more comfortable than current injections.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11030844

• Analyzing tissue samples to understand autoimmune diseases

  This study is looking at how different cells and molecules in your body work together in autoimmune diseases like rheumatoid arthritis and lupus, using samples from patients to help find better ways to treat these conditions.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11017785

• Analyzing single cells and tissues from patients with autoimmune diseases

  This study is looking at how autoimmune diseases like rheumatoid arthritis, psoriasis, and lupus affect the body by examining blood and tissue samples from patients, with the goal of finding new ways to treat these conditions.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11015810

• Understanding how GABA affects immune responses in autoimmune diseases

  This study is looking at how a substance called GABA affects inflammation caused by immune cells, with the hope of finding new treatments for autoimmune diseases that could help patients feel better.

  NIH research Research Inst Nationwide Children's Hosp · Columbus, United States · NIH-11012895

• Understanding how autoimmune diseases affect certain brain receptors

  This study is looking at how the immune system might mistakenly attack certain brain receptors in people with neurological diseases like myasthenia gravis and autoimmune encephalitis, and it aims to find out more about how these attacks happen by examining blood and spinal fluid from patients.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11005383

• Investigating how unique antibody sequences may contribute to autoimmune diseases.

  This study is looking at special types of antibodies in people with autoimmune diseases and healthy individuals to see how they might affect the immune system, helping us learn more about these conditions and how to better understand them.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-10991364

• Identifying biomarkers for autoimmune diseases triggered by immunotherapy

  This study is looking at how certain cancer treatments called immunotherapy might cause autoimmune diseases in patients, and it aims to find markers that can help predict who might be at risk, so that those receiving these treatments can have safer options.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10917057

• Targeting B cells to treat pemphigus vulgaris without immunosuppression

  This study is looking for new ways to help people with pemphigus vulgaris by targeting the harmful cells that cause painful blisters, using blood samples from patients and animal models to find safer treatments that have fewer side effects than current options.

  NIH research Dana-Farber Cancer Inst · Boston, United States · NIH-10913296

• Targeting MHC proteins to improve cancer and autoimmune disease treatments

  This study is looking at ways to boost the immune system's ability to fight cancer by improving how cancer markers are shown to immune cells, and it may also help people with autoimmune diseases like ankylosing spondylitis and celiac disease by creating new treatments that better manage their conditions.

  NIH research University of California Berkeley · Berkeley, United States · NIH-10910441

• Targeting a specific receptor to treat autoimmune diseases and blood cancers

  This study is looking at how a specific receptor related to prolactin might play a role in the development of certain blood cancers, especially in people with autoimmune disorders like lupus, to help find new ways to treat these conditions early on.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-10889016

• Understanding immune responses in autoimmune diseases like lupus and diabetes

  This study is looking at how certain immune system parts, like antibodies and T cell pieces, relate to autoimmune diseases such as lupus and rheumatoid arthritis, to help find better treatments and understand these conditions more clearly for patients.

  NIH research La Jolla Institute for Immunology · La Jolla, United States · NIH-10788230

• Understanding immune responses in autoimmune diseases

  This study is all about gathering and sharing information on how our immune system works with autoimmune diseases like lupus and rheumatoid arthritis, so that patients can better understand their conditions and how to manage them.

  NIH research La Jolla Institute for Immunology · La Jolla, United States · NIH-10551167

• Understanding immune responses in autoimmune diseases like lupus and type 1 diabetes

  This study is all about gathering helpful information on how our immune system works with autoimmune diseases like lupus and rheumatoid arthritis, so that patients can get better treatments and a clearer understanding of their health.

  NIH research La Jolla Institute for Immunology · La Jolla, United States · NIH-10021128

Related topics

Quick answers

How many Autoimmune Diseases clinical trials are recruiting right now?

72, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 20 countries. The most sites are in China (28 trials), United States (20 trials), France (9 trials), United Kingdom (4 trials), Canada (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 13, Phase 1: 7, Phase 1/2: 5, Phase 2: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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