Effects of phytocannabinoids on immune response in chronic inflammatory diseases

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the impact of phytocannabinoids, such as cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), on the immune response and autophagy in patients with chronic immune-mediated inflammatory diseases. By collecting blood samples as part of routine care, the study aims to explore how these compounds may modulate inflammation and immune function through their interaction with the endocannabinoid system. The research focuses on conditions like rheumatoid arthritis, spondyloarthritis, and inflammatory bowel diseases, assessing the potential therapeutic benefits of phytocannabinoids in these populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Male or female ≥ 18 years old
2. Diagnosis confirmed by a rheumatologist of RA or spondyloarthropathy (with or without IBD) or psoriatic arthritis (with or without active psoriasis) or systemic lupus erythematosus or Sjögren's disease
3. Patient who has expressed consent to participate in the study
4. Patients affiliated to social security
5. Treatments authorized as part of routine care: non-steroidal anti-inflammatory drugs (NSAIDs), level 1 to 3 analgesics, local corticosteroids, oral corticosteroid therapy (daily dose ≤15 mg/d), 5-aminosalicylic acid, salazopyrine, methotrexate, leflunomide, hydroxychloroquine, biotherapies and targeted therapies.

Exclusion Criteria:

1. Patient who received intravenous corticosteroid therapy less than 4 weeks ago
2. Patient receiving oral corticosteroid therapy with a daily dose \>15 mg/day
3. Consumption of CBD and/or recreational cannabis and/or positive saliva test for cannabis consumption and/or CBD
4. Pregnant and lactating women
5. Persons under guardianship or curatorship

Where it's running

• CHU d'ORLEANS
  Orléans, France Recruiting

Study contacts

• Principal investigator: Carine Pr SALLIOT — CHU Orléans
• Study coordinator: Carine Pr SALLIOT, PhD
• Email: carine.salliot@chu-orleans.fr
• Phone: 02 38 22 99 22

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.