Condition

Primary Sclerosing Cholangitis clinical trials and research

• 22Clinical trials
• 2NIH research projects
• 25Countries

Newest Primary Sclerosing Cholangitis clinical trials

All recruiting trials (22)

• Elafibranor for adults with primary sclerosing cholangitis

  This trial will see if taking elafibranor once daily helps adults with primary sclerosing cholangitis compared with a placebo.

  Recruiting at 41 sites Phase 3 Ipsen · Chandler, Arizona and 230 other locations · NCT07387549

• TAK-781 treatment in healthy adults and people with non-cirrhotic primary sclerosing cholangitis

  This study will test whether TAK-781 is safe and tolerable in healthy adults and in people with non-cirrhotic primary sclerosing cholangitis while measuring how the body handles and responds to the drug.

  Recruiting Phase 1 Takeda · Salt Lake City, Utah · NCT07229911

• Preventing recurrence of primary sclerosing cholangitis after liver transplantation

  This study is testing if a daily medication called fenofibrate can help prevent primary sclerosing cholangitis from coming back in people who have had a liver transplant.

  Recruiting Phase 2 Mayo Clinic · Scottsdale, Arizona · NCT06905054

• LEOPARD: Predicting liver transplant dropout with AI in European patients

  This project tests new AI-based models to predict which liver transplant candidates are at highest risk of dropout or death while on the waitlist.

  Recruiting at 4 sites Assistance Publique - Hôpitaux de Paris · Ghent, Belgium and 7 other locations · NCT06723275

• Collecting data to improve liver transplantation predictions

  This study is trying to use AI to better predict which liver transplant candidates are at risk of dropping out of the waitlist, so that more people can get fair access to transplants across Europe.

  Recruiting at 53 sites Assistance Publique - Hôpitaux de Paris · Vienna and 52 other locations · NCT06675604

• Identifying liver disease-specific gut microbiomes

  This study is trying to find out if certain gut bacteria are linked to chronic liver diseases in adults, including autoimmune hepatitis and primary biliary cholangitis, by analyzing blood and stool samples from patients and their household members.

  Recruiting Chungnam National University Hospital · Daejeon, Jung-gu · NCT06519162

• Using Siplizumab to prevent immune issues in liver transplant patients with autoimmune liver disease

  This study is testing if a new medication called siplizumab can help prevent immune problems in adults with autoimmune liver disease who are getting a liver transplant.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06455280

• Fecal Microbiota Transplant for Primary Sclerosing Cholangitis

  This study is testing whether a stool transplant from healthy donors can help people with Primary Sclerosing Cholangitis feel better and improve their quality of life.

  Recruiting at 5 sites Phase 2 University of Birmingham · Birmingham and 4 other locations · NCT06286709

• Using oral microbiota therapy to treat primary sclerosing cholangitis

  This study is testing a new treatment using oral antibiotics to see if it can help people with primary sclerosing cholangitis feel better.

  Recruiting Early Phase 1 University of Minnesota · Minneapolis, Minnesota · NCT06197308

• Using statins to understand and treat Primary Sclerosing Cholangitis

  This study is testing if the cholesterol-lowering drug rosuvastatin can help people with Primary Sclerosing Cholangitis by looking at how it affects their bile acids and gut bacteria.

  Recruiting Early Phase 1 Stanford University · Stanford, California · NCT05912387

• Using vancomycin to treat primary sclerosing cholangitis in Italy

  This study is testing whether two different doses of the antibiotic vancomycin can help improve liver function in people aged 15 to 70 with primary sclerosing cholangitis.

  Recruiting Phase 2 University of Milano Bicocca · Monza, Monza E Brianza · NCT05876182

• Treatment for liver detoxification in patients with primary sclerosing cholangitis

  This study is testing a new oral medication called BRS201 to see if it can improve liver function and overall health in people with primary sclerosing cholangitis.

  Recruiting Phase 2 Brigham and Women's Hospital · Chestnut Hill, Massachusetts · NCT05835505

• Improving outcomes in pediatric autoimmune liver disease

  This study is trying to improve care for kids with autoimmune liver diseases by collecting and sharing information about their treatments and health to help doctors provide better support.

  Recruiting at 8 sites Children's Hospital Medical Center, Cincinnati · Palo Alto, California and 7 other locations · NCT05750498

• National database for patients with primary sclerosing cholangitis

  This study is creating a national database for people in Italy with primary sclerosing cholangitis to gather important health information and improve understanding of the disease.

  Recruiting University of Milano Bicocca · Ancona and 62 other locations · NCT05618145

• Using hymecromone to treat primary sclerosing cholangitis in adolescents and adults

  This study is testing if adding hymecromone to standard treatment can help adolescents and adults with primary sclerosing cholangitis feel better and improve their liver function.

  Recruiting at 2 sites Phase 2 Stanford University · Redwood City, California and 1 other locations · NCT05295680

• Collecting bile samples from patients with Primary Sclerosing Cholangitis and controls

  This study is collecting bile samples from people with Primary Sclerosing Cholangitis and healthy individuals to see how the disease affects the body and find new ways to treat it.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT04753996

• Understanding the causes of primary sclerosing cholangitis

  This study looks at the causes of primary sclerosing cholangitis by collecting health information and samples from people with the disease to see what genetic and immune factors might be involved.

  Recruiting National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT04685200

• Understanding Primary Sclerosing Cholangitis in Children

  This study is trying to learn more about how primary sclerosing cholangitis affects children by collecting health information and samples to understand the disease better and its connection to other conditions.

  Recruiting at 9 sites Arbor Research Collaborative for Health · Los Angeles, California and 11 other locations · NCT04181138

• Biobank for cholestatic liver diseases

  This study is collecting samples and health information from people with cholestatic liver diseases to see if it can help us better understand these conditions and improve how we detect and predict them.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT03445585

• Using MRI to predict outcomes in children with autoimmune liver disease

  This study is testing if MRI scans can help predict how well children with autoimmune liver diseases will do over time.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT03178630

• Using MRI to assess liver damage in children with autoimmune liver disease

  This study is testing if MRI scans can safely show liver damage in children with autoimmune liver diseases like PSC and AIH, helping doctors understand their condition better without needing invasive tests.

  Recruiting Children's Hospital Medical Center, Cincinnati · Cincinnati, Ohio · NCT03175471

• Using vancomycin to treat Primary Sclerosing Cholangitis and Biliary Atresia

  This study is testing if the antibiotic vancomycin can help improve the health of people with Biliary Atresia and Primary Sclerosing Cholangitis while also looking at how it affects the gut bacteria.

  Recruiting Phase 1 Sacramento Pediatric Gastroenterology · Sacramento, California · NCT02137668

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How the tissue around your bile ducts affects primary sclerosing cholangitis

  This project looks at whether lowering a material called hyaluronan and softening stiff tissue around bile ducts could help people with primary sclerosing cholangitis (PSC).

  NIH research Veterans Admin Palo Alto Health Care Sys · Palo Alto, United States · NIH-11204586

• Investigating the effects of oral vancomycin on liver disease in adults with primary sclerosing cholangitis.

  This study is looking for adults with primary sclerosing cholangitis (PSC) to see if taking an oral medication called vancomycin can help reduce liver inflammation and improve liver function, which could lead to better treatment options for this serious condition.

  NIH research Mayo Clinic Arizona · Scottsdale, United States · NIH-10474350

Related topics

Quick answers

How many Primary Sclerosing Cholangitis clinical trials are recruiting right now?

22, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (16 trials), Italy (5 trials), Belgium (3 trials), France (3 trials), Germany (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 3, Early Phase 1: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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