Identifying biomarkers in inflammatory bowel disease
Official title: IDENTIFICATION OF PROGNOSTIC AND PREDICTIVE BIOMARKERS OF NATURAL HISTORY AND RESPONSE TO BIOTHERAPIES IN INFLAMMATORY BOWEL DISEASE : i-BANK
Run by Central Hospital, Nancy, France · NCT03809728 · Data updated 2026-11-12
This study is trying to find specific markers in people with Crohn's disease and ulcerative colitis that can help predict how their disease will progress and how well they will respond to new treatments.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Central Hospital, Nancy, France Academic / other |
| Drugs / interventions | ustekinumab, vedolizumab |
| Locations | 1 site (Vandœuvre-lès-Nancy) |
| Status | Recruiting |
| Started | December 10, 2019 |
| Main results expected | December 10, 2034 |
| Study ends | December 10, 2034 |
| Registry record updated | February 7, 2024 |
| Trial ID | NCT03809728 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18 and older with a confirmed diagnosis of Crohn's disease or ulcerative colitis.
✕Probably not a fit
Patients with undetermined colitis or those without an established diagnosis of Crohn's disease may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on patients with inflammatory bowel diseases, specifically Crohn's disease and ulcerative colitis, to identify biomarkers that can predict disease progression and response to biotherapies. It evaluates treatment responses through various objective measures, including endoscopic, radiological, and biological assessments. The study also correlates treatment outcomes with genomic, epigenomic, and microbiota data, taking into account environmental factors such as nutrition and physical activity.
Why it matters
Potential benefit: If successful, this study could lead to more personalized treatment strategies for patients with inflammatory bowel diseases.
How similar studies have gone: Other studies have shown promise in identifying biomarkers for inflammatory bowel diseases, suggesting that this approach has potential for success.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age\>=18 years * Patients with an established diagnosis of CD or UC (clinical, biological, radiological, endoscopic or histologic criteria) * Patients \>=45 kg * Affiliated member of the Social Security system Exclusion Criteria: * Patients with an undetermined colitis * Patients with a non established diagnosis of CD * Women of childbearing age without a method of contraception * Persons covered by articles L. 1121-5, L. 1121-7 and L1121-8 of the Public Health Code * Pregnant women, breastfeeding women \-- Age \< 18 years * Persons under legal protection * Person who does not have the capacity to consent * Persons under the age of 18 years who are deprived of their liberty by decision of a judicial or administrative authority (articles L. 3212-1 and L. 3213-1).
Where it's running
-
CHRU Nancy
Vandœuvre-lès-Nancy, France Recruiting
Study contacts
- Principal investigator: Adeline GERMAIN, MD, PhD — CHRU Nancy
- Study coordinator: Adeline GERMAIN, MD, PhD
- Email: a.germain@chru-nancy.fr
- Phone: +33383153120
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Self-management program to improve health in inflammatory bowel disease
A digital self-management program is being tested to see if it helps people with inflammatory bowel disease feel better and manage their symptoms alongside standard care.
-
Observational study comparing inflammatory markers in IBD and non-IBD participants
This study is trying to see how inflammation levels in people with Crohn's Disease and Ulcerative Colitis compare to those without these conditions when they start new treatments.
-
Evaluating robotic surgery for inflammatory bowel disease
This study is testing if robotic surgery can be a good option for adults with inflammatory bowel disease, like Crohn's or ulcerative colitis, compared to traditional surgery methods.
-
How nutrition and body composition relate to outcomes in people with IBD
This study will see if nutrition and muscle mass affect outcomes in people with Crohn's disease or ulcerative colitis who are starting advanced medicines or having IBD-related surgery.
-
Research on gut inflammation in pediatric patients with inflammatory bowel diseases
This study is trying to learn more about gut inflammation in kids with inflammatory bowel diseases by collecting health information and samples from them and comparing it to kids who have different gut issues but no inflammation.
-
Switching to subcutaneous infliximab for IBD treatment
This study is testing if switching people with inflammatory bowel disease from an intravenous form of infliximab to a subcutaneous version, given weekly or bi-weekly, can lead to better health results.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.