Analyzing genetic factors in inflammatory bowel disease across different populations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to investigate the genetic and environmental factors contributing to inflammatory bowel disease (IBD) by analyzing clinical data and genome samples from affected individuals and healthy controls. Participants will provide blood or saliva samples to facilitate genetic analysis. The study seeks to identify susceptible genes that may play a role in the pathogenesis of IBD, which includes conditions like Crohn's disease and ulcerative colitis. By understanding these factors, the research hopes to shed light on the increasing incidence of IBD across various populations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects: diagnosed with Inflammatory Bowel Disease (Crohn's disease, ulcerative colitis, IBD-undetermined)
* Available medical records to confirm IBD diagnosis (Crohn's disease, Ulcerative colitis, IBD undetermined (IBD-U))
* Healthy controls: no personal history of IBD, no family history of IBD, no history of unexplained chronic diarrhea/blood in stool/anemia/abdominal pain/weight loss
* Any age

Exclusion Criteria:

\- Subjects with other gastrointestinal conditions not meeting the above IBD or Healthy Control criteria

Where it's running

• Sinai Health System
  Toronto, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Mark Silverberg, MD PhD — Sinai Health System
• Study coordinator: Joanne Stempak, MSc
• Email: joanne.stempak@sinaihealth.ca
• Phone: 4165864800

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Observational study comparing inflammatory markers in IBD and non-IBD participants

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• Evaluating robotic surgery for inflammatory bowel disease

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• How nutrition and body composition relate to outcomes in people with IBD

  This study will see if nutrition and muscle mass affect outcomes in people with Crohn's disease or ulcerative colitis who are starting advanced medicines or having IBD-related surgery.

  Recruiting Barts & The London NHS Trust · London · NCT06550310

• Research on gut inflammation in pediatric patients with inflammatory bowel diseases

  This study is trying to learn more about gut inflammation in kids with inflammatory bowel diseases by collecting health information and samples from them and comparing it to kids who have different gut issues but no inflammation.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT06315179

• Switching to subcutaneous infliximab for IBD treatment

  This study is testing if switching people with inflammatory bowel disease from an intravenous form of infliximab to a subcutaneous version, given weekly or bi-weekly, can lead to better health results.

  Recruiting at 14 sites Phase 4 Belgian Inflammatory Bowel Disease Research and Development (BIRD) VZW · Ghent, Oost-Vlaanderen and 14 other locations · NCT06113913

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.