Condition

Crohn Disease clinical trials and research

• 123Clinical trials
• 2New in 30 days
• 37Countries

Newest Crohn Disease clinical trials

All recruiting trials (123)

• Microencapsulated Propionate vs Butyrate for Crohn's Disease in Remission

  This study tests whether microencapsulated sodium propionate can favorably alter the gut microbiota and inflammation in adults with Crohn’s disease, compared with sodium butyrate.

  Recruiting University of Padova · Padova · NCT07883044

• Risankizumab for Refractory Perianal Fistulizing Crohn's Disease

  This study tests whether risankizumab can help people with Crohn’s disease who have draining perianal fistulas not responding to other treatments.

  Recruiting Phase 4 Hyogo Medical University · Nishinomiya and 3 other locations · NCT07872449

• Intestinal ultrasound-guided management for inflammatory bowel disease

  This study tests if adding point-of-care intestinal ultrasound at every visit changes treatment decisions for adults with Crohn’s disease or ulcerative colitis undergoing disease assessment.

  Recruiting Mahidol University · Bangkok · NCT07775352

• Laser-based sizing of GI lesions during endoscopies

  This study tests whether the AccuMeasure laser tool gives more accurate and reliable lesion size measurements during colonoscopies for adults with colon polyps or Crohn’s disease than traditional endoscopic estimates.

  Recruiting Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT07770425

• A Probiotic Approach to Modulating Gut Microbiota in Mild-to-Moderate Ulcerative Colitis

  A specific probiotic given rectally will be tested in adults with mild-to-moderate ulcerative colitis to see if it can help manage symptoms.

  Recruiting Catholic University of the Sacred Heart · Roma, RM · NCT07724990

• Claudin-2 Immunostaining to Detect Active or Inactive Inflammation in IBD Biopsies

  This study tests whether staining for Claudin-2 in intestinal biopsy samples can help identify active vs. inactive inflammation in people with ulcerative colitis or Crohn's disease.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Mi · NCT07710287

• Guselkumab in Breast Milk for Lactating Women on Guselkumab

  This study tests how much guselkumab is present in the breast milk of lactating women who are already receiving guselkumab for their approved conditions.

  Recruiting Phase 4 Janssen Research & Development, LLC · Chapel Hill, North Carolina · NCT07654751

• Guselkumab use in Crohn's disease and ulcerative colitis

  This study looks at how long people with moderate-to-severe Crohn's disease or ulcerative colitis stay on guselkumab in real-world care.

  Recruiting Janssen-Cilag Pharma GmbH · Vienna · NCT07606339

• JNJ-78934804 in Crohn’s disease: a comparison to guselkumab for moderate to severe cases

  This trial tests whether JNJ-78934804 works as well as guselkumab for adults with moderately to severely active Crohn’s disease over 48 weeks.

  Recruiting at 285 sites Phase 3 Janssen Research & Development, LLC · Scottsdale, Arizona and 286 other locations · NCT07577843

• Guselkumab in Ulcerative Colitis and Crohn’s Disease in Saudi Arabia: Real-World Use

  This study looks at how long people with moderate-to-severe Crohn’s disease or ulcerative colitis continue taking guselkumab in everyday clinical practice in Saudi Arabia.

  Recruiting Janssen Research & Development, LLC · Jeddah · NCT07541261

• Real-world use of guselkumab in Crohn’s disease and ulcerative colitis

  This study tests how long guselkumab stays in the bodies of adults with moderate-to-severe Crohn’s disease or ulcerative colitis treated in real-world clinical settings.

  Recruiting Janssen-Cilag A.G., Switzerland · Bern · NCT07532213

• Guselkumab versus risankizumab for moderate-to-severe Crohn's disease

  This comparison tests whether guselkumab or risankizumab works better to reduce intestinal inflammation in people with moderately to severely active Crohn's disease.

  Recruiting at 162 sites Phase 3 Janssen Research & Development, LLC · Dothan, Alabama and 163 other locations · NCT07499232

• Flu? No—A combination of an FXR activator and mirikizumab for adults with Crohn's disease

  This study tests whether adding the FXR activator LY4395089 to mirikizumab is better than mirikizumab alone for adults with moderately to severely active Crohn's disease.

  Recruiting at 53 sites Phase 2 Eli Lilly and Company · Scottsdale, Arizona and 70 other locations · NCT07483099

• New treatments for adults with ulcerative colitis or Crohn's disease

  This study tests new treatments for adults with moderately to severely active ulcerative colitis or Crohn's disease to see if they work and are safe.

  Recruiting at 55 sites Phase 2 Eli Lilly and Company · Scottsdale, Arizona and 70 other locations · NCT07483073

• Self-management program to improve health in inflammatory bowel disease

  A digital self-management program is being tested to see if it helps people with inflammatory bowel disease feel better and manage their symptoms alongside standard care.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07456566

• Partial enteral nutrition to help IBD patients at nutritional risk maintain weight

  We’re testing whether adding an oral nutritional supplement (LH VIOLA) to standard counseling helps adults with IBD who are at risk of malnutrition keep or gain weight over 16 weeks.

  Recruiting at 4 sites Lionhealth Srl Società Benefit · Rozzano, Milano and 3 other locations · NCT07433946

• Measuring how common and how treatment-resistant difficult-to-treat Crohn's disease is in China.

  This project will measure how common difficult-to-treat Crohn's disease is in adults in China and see how their treatment responses and prognosis compare to other Crohn's patients.

  Recruiting Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT07364734

• Guselkumab for Chinese patients with Crohn's disease who stopped responding to ustekinumab

  This study tests whether guselkumab can help Chinese patients with active Crohn's disease who initially responded to ustekinumab but later lost response.

  Recruiting at 5 sites Phase 4 Xian-Janssen Pharmaceutical Ltd. · Guangzhou and 4 other locations · NCT07310095

• Gut bacteria and immune-cell energy in people with IBD and healthy adults

  We will test whether gut bacteria change how immune cells use energy in people with Crohn's disease or ulcerative colitis and in healthy adults by using a short antibiotic course and a labeled fiber.

  Recruiting Phase 2 Assistance Publique - Hôpitaux de Paris · Paris · NCT07300553

• Lower GI imaging with a tethered camera capsule

  This test tries a small camera capsule on a string that takes pictures of the lower gut without sedation for adults who are healthy or who have Lynch syndrome, Crohn's disease, or other inflammatory bowel diseases.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07219537

• COMPARE — Newer IBD treatments in children

  This project compares the safety and effectiveness of newer IBD medicines for children with Crohn's disease or ulcerative colitis who did not respond to anti‑TNF treatment.

  Recruiting at 4 sites University of North Carolina, Chapel Hill · Chapel Hill, North Carolina and 3 other locations · NCT07198113

• Icotrokinra for moderately to severely active Crohn's disease

  This trial will test whether icotrokinra helps people with moderately to severely active Crohn's disease reduce intestinal inflammation and symptoms compared with a placebo.

  Recruiting at 382 sites Phase 2/3 Janssen Research & Development, LLC · Chandler, Arizona and 394 other locations · NCT07196722

• FAPI PET imaging to find fibrotic bowel in Crohn's disease

  This project will try FAPI PET imaging to see if it can detect bowel scarring in people with ileal Crohn's disease who are about to start biologic treatment.

  Recruiting University of Edinburgh · Edinburgh · NCT07152431

• Microplastic levels in children with and without inflammatory bowel disease

  This project will test whether children with Crohn's disease or ulcerative colitis have higher levels of microplastics in intestinal tissue, stool, urine, or blood than children without IBD.

  Recruiting Medical University of Gdansk · Gdansk · NCT07141238

• Cardiovascular risk in people with Crohn's disease and ulcerative colitis

  This study tests whether people with inflammatory bowel disease have different heart-attack or stroke risk over two years compared with matched controls.

  Recruiting IRCCS Policlinico S. Donato · San Donato Milanese, Milan · NCT07095634

• Wireless thermal capsule to detect gastrointestinal temperature changes

  This study tests a swallowable wireless thermal capsule to see if it can collect temperature data from the GI tract in healthy adults.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT07033208

• Mirikizumab in Crohn's-related strictures: open-label, single-arm study

  This study tests whether mirikizumab can help adults with inflammatory strictures from Crohn's disease across several centers in Canada, the UK, and the US.

  Recruiting at 5 sites Phase 4 Alimentiv Inc. · Miami, Florida and 7 other locations · NCT06997965

• Observational study on patients switching to a biosimilar treatment for Crohn's disease and plaque psoriasis

  This study is testing if switching to a new biosimilar treatment for Crohn's disease and plaque psoriasis helps patients stay in remission and feel satisfied with their care.

  Recruiting Celltrion HealthCare France · Amiens · NCT06997055

• Examining the link between polyamine levels and inflammatory bowel disease progression

  This study is trying to see if measuring certain substances in the body can help predict how inflammatory bowel diseases like Ulcerative Colitis and Crohn's Disease will progress in patients.

  Recruiting Xijing Hospital · Xi'an, Shaanxi · NCT06995170

• Observational study comparing inflammatory markers in IBD and non-IBD participants

  This study is trying to see how inflammation levels in people with Crohn's Disease and Ulcerative Colitis compare to those without these conditions when they start new treatments.

  Recruiting University of Nottingham · Nottingham, Nottinghamshire · NCT06956703

• Prednisolone versus an adapted Crohn's disease exclusion diet plus partial enteral nutrition for adult Crohn's flares

  This trial tests whether an adapted Crohn's exclusion diet combined with partial enteral nutrition works as well as prednisolone for adults experiencing a Crohn's disease flare.

  Recruiting Phase 2 University Hospital Tuebingen · Tübingen · NCT06953791

• Online positive psychology program to improve mental health and quality of life in Crohn's disease

  This trial will try an online positive psychology program to improve mood and quality of life for adults with Crohn's disease who have mild to moderate anxiety or depression.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT06939712

• Using advanced imaging to assess inflammation in bowel diseases

  This study is testing if a new imaging technique can help doctors better see inflammation in patients with Inflammatory Bowel Disease compared to the standard method.

  Recruiting University of Ulm · Ulm, Baden-Wurttemberg · NCT06892990

• Evaluating fecal transplant and diet changes for Crohn's disease

  This study is testing whether a fecal transplant and a special diet can help people with newly diagnosed mild to moderate Crohn's disease feel better.

  Recruiting All India Institute of Medical Sciences · Kochi, Kerala and 5 other locations · NCT06890650

• Malaysian-adapted Asian Crohn's disease diet

  This trial will test a Malaysian-adapted Asian version of the Crohn's Disease Exclusion Diet to see if it improves symptoms and the gut microbiome in people with mild-to-moderate Crohn's disease.

  Recruiting University of Malaya · Kuala Lumpur, Petaling Jaya · NCT06871267

• Ileocolic resection with extended mesenteric removal for Crohn's disease

  This trial will try removing more of the mesentery during ileocolic surgery in people with Crohn's disease who are on biologic medicines to see if it is safe and reduces early endoscopic recurrence.

  Recruiting at 2 sites Centre Hospitalier Universitaire de Nīmes · Montpellier and 1 other locations · NCT06856044

• Tissue repair in inflammatory bowel disease using organoid technology

  This project will try organoid techniques on intestinal samples from adults with Crohn's disease or ulcerative colitis to see how their gut lining repairs after inflammation.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT06805890

• Comparing MR Enterography and Ultrasound for Assessing Crohn's Disease Treatment Response

  This study is testing whether MR Enterography or Intestinal Ultrasound is better at showing how well treatment is working for people with Crohn's disease who are 16 and older.

  Recruiting University College, London · London · NCT06800326

• Using urine samples to diagnose gastrointestinal diseases

  This study is testing a new way to use urine samples to see if it can help diagnose different gastrointestinal diseases like colorectal cancer and Crohn's disease.

  Recruiting at 4 sites Luventix, Inc. · Encinitas, California and 3 other locations · NCT06710067

• Long-term safety and effectiveness of tulisokibart for Crohn's disease and ulcerative colitis

  This study is testing if the medication tulisokibart is safe and effective for people with moderate to severe Crohn's disease and ulcerative colitis over a longer period of time.

  Recruiting at 34 sites Phase 3 Merck Sharp & Dohme LLC · Bristol, Connecticut and 36 other locations · NCT06651281

• Donor fat-derived stem cell injections for complex perianal Crohn's fistulas

  This treatment will try injecting donor adipose-derived stem cells into complex perianal fistulas in adults with Crohn's disease who did not improve after drainage and biologic therapy.

  Recruiting Phase 1/2 University Hospital, Toulouse · Toulouse · NCT06636032

• Microbiota transplant therapy for Crohn's disease

  This study is testing two types of microbiota transplants to see if they can help people with Crohn's disease feel better and improve their gut health.

  Recruiting at 2 sites Phase 2 University of Minnesota · Minneapolis, Minnesota and 2 other locations · NCT06631586

• Evaluating robotic surgery for inflammatory bowel disease

  This study is testing if robotic surgery can be a good option for adults with inflammatory bowel disease, like Crohn's or ulcerative colitis, compared to traditional surgery methods.

  Recruiting at 6 sites University Hospitals Coventry and Warwickshire NHS Trust · Coventry, West Midlands and 5 other locations · NCT06579443

• How nutrition and body composition relate to outcomes in people with IBD

  This study will see if nutrition and muscle mass affect outcomes in people with Crohn's disease or ulcerative colitis who are starting advanced medicines or having IBD-related surgery.

  Recruiting Barts & The London NHS Trust · London · NCT06550310

• Using statins to prevent strictures in Crohn's disease

  This study is testing if taking statins can help adults with Crohn's disease avoid getting strictures after surgery.

  Recruiting Early Phase 1 Stanford University · Stanford, California · NCT06538649

• Comparing dual-target therapy with intensified Ustekinumab for Crohn's disease

  This study is testing if a new combination treatment of Ustekinumab and Upadacitinib can help people with Crohn's disease feel better compared to a higher dose of Ustekinumab alone.

  Recruiting Phase 4 Sixth Affiliated Hospital, Sun Yat-sen University · Guangzhou, Guangdong · NCT06520397

• Identifying biomarkers for predicting complications after surgery in inflammatory bowel disease

  This study is trying to find specific markers in patients with inflammatory bowel disease after surgery to see if they can help predict complications and the chance of the disease coming back.

  Recruiting IRCCS Ospedale San Raffaele · Milan, Italy · NCT06516341

• Effects of prebiotics on gut health in ulcerative colitis

  This study is testing if taking prebiotics can improve gut health in people with ulcerative colitis who have active symptoms.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT06495658

• Exploring the role of proteins in Crohn's Disease

  This study is trying to see how proteins in the gut and the bacteria living there affect people with Crohn's Disease to find new ways to manage the condition.

  Recruiting at 2 sites Weizmann Institute of Science · Hamburg and 1 other locations · NCT06494826

• Measuring a biomarker in patients with chronic mesenteric ischemia

  This study is testing if measuring a specific protein in the blood can help doctors better understand and treat patients with chronic mesenteric ischemia and related conditions.

  Recruiting Oslo University Hospital · Oslo, Oslo · NCT06468774

• Predicting treatment outcomes for Crohn's disease using gut microbiome analysis

  This study is trying to see if certain gut bacteria can help predict how well treatments will work for adults with Crohn's disease in British Columbia.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT06453720

• Immune signals and regulatory T cells in migraine

  This research will test whether blood immune markers and regulatory T cells are linked to migraine in women ages 18–50 who have migraine or certain autoimmune/inflammatory conditions.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand, AURA · NCT06426316

• Research on gut inflammation in pediatric patients with inflammatory bowel diseases

  This study is trying to learn more about gut inflammation in kids with inflammatory bowel diseases by collecting health information and samples from them and comparing it to kids who have different gut issues but no inflammation.

  Recruiting Seattle Children's Hospital · Seattle, Washington · NCT06315179

• Comparing bowel preparation methods for colonoscopy in patients with Crohn's and Ulcerative Colitis

  This study is testing which bowel prep method, oral sulfate solution or polyethylene glycol, works better and is easier for adults with Crohn's disease or ulcerative colitis who need a colonoscopy.

  Recruiting Phase 4 University of Manitoba · Winnipeg, Manitoba · NCT06298461

• Evaluating Transmural Healing in Crohn's Disease Treatment

  This study is testing if a new way of treating Crohn's disease that uses noninvasive ultrasound to track healing can help patients stay off corticosteroids and feel better compared to standard treatment.

  Recruiting at 51 sites Phase 4 Alimentiv Inc. · Los Angeles, California and 68 other locations · NCT06257706

• Using advanced imaging to assess Crohn's disease

  This study is testing a new type of imaging to see if it can better identify certain problems in the intestines of people with Crohn's disease who might need surgery.

  Recruiting Massachusetts General Hospital · Charlestown, Massachusetts · NCT06252493

• Smartphone app to improve psychological wellbeing in Crohn's disease patients

  This study is testing a smartphone app to see if it can help people with Crohn's disease feel less stressed, tired, and in pain while improving their overall wellbeing.

  Recruiting Soroka University Medical Center · Beersheba and 3 other locations · NCT06221254

• Comparing two types of nutrition for children with Crohn's disease

  This study is testing whether a regular nutrition formula or a homemade smoothie recipe works better for kids with Crohn's disease to see which one helps them feel better.

  Recruiting Seattle Children's Hospital · Philadelphia, Pennsylvania and 2 other locations · NCT06216899

• Endoscopic strictureplasty versus balloon dilation for Crohn's intestinal strictures

  This will test whether endoscopic strictureplasty or balloon dilation works better to open intestinal narrowings caused by Crohn's disease in adults 18 to 75.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Hangzhou · NCT06203782

• Gastro-intestinal biopotentials recordings using a腹 surface device across healthy people and digestive disease patients

  A home-made abdominal surface-electrode device tests whether gut biopotentials differ among healthy volunteers, Crohn’s disease patients (with and without fibrosis), and people with functional GI disorders.

  Recruiting at 2 sites Central Hospital, Nancy, France · Vandœuvre-lès-Nancy, CHRU de Nancy and 1 other locations · NCT06197334

• Improving capsule endoscopy diagnostics with artificial intelligence

  This study is testing whether using artificial intelligence can help doctors read capsule endoscopy images more accurately and quickly for patients getting this routine procedure.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT06152289

• Testing infrared therapy for Crohn's disease

  This study is testing if far infrared therapy can help people with Crohn's disease feel better compared to a placebo treatment.

  Recruiting Tel-Aviv Sourasky Medical Center · Tel Aviv · NCT06146816

• Switching to subcutaneous infliximab for IBD treatment

  This study is testing if switching people with inflammatory bowel disease from an intravenous form of infliximab to a subcutaneous version, given weekly or bi-weekly, can lead to better health results.

  Recruiting at 14 sites Phase 4 Belgian Inflammatory Bowel Disease Research and Development (BIRD) VZW · Ghent, Oost-Vlaanderen and 14 other locations · NCT06113913

• Observational study on safety concerns in IBD patients treated with specific therapies in France

  This study is trying to see if certain treatments for Crohn's disease and ulcerative colitis are safe and if they affect patients' health and costs over time.

  Recruiting at 2 sites Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives · Amiens and 1 other locations · NCT06089590

• Evaluating inflammation in children with inflammatory bowel disease

  This study is testing a new device to see how it can help doctors understand inflammation in children with Crohn's disease and ulcerative colitis, so they can provide better treatment.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06065228

• Infliximab treatment for Crohn's disease with drug monitoring

  This study is testing if adjusting infliximab treatment based on drug levels helps people with active perianal fistulizing Crohn's disease feel better compared to standard fixed dosing.

  Recruiting Phase 4 Asan Medical Center · Seoul · NCT06051253

• Analyzing genetic factors in inflammatory bowel disease across different populations

  This study is trying to find out how genes and the environment affect inflammatory bowel disease by looking at samples from people with the condition and healthy individuals.

  Recruiting Mount Sinai Hospital, Canada · Toronto, Ontario · NCT06042387

• Comparing Kono-S anastomosis to standard surgery for Crohn's disease

  This study is testing a new surgical technique called Kono-S to see if it can help adults with Crohn's disease have fewer problems after surgery compared to standard surgery.

  Recruiting Centre Hospitalier Universitaire de Besancon · Besançon and 14 other locations · NCT05974358

• Treatment of anal fistulas using stem cells

  This study is testing if a new stem cell treatment can help people with complex anal fistulas caused by Crohn's disease feel better after surgery.

  Recruiting Nantes University Hospital · Nantes, Nantes · NCT05974280

• Evaluating the best first-line treatment for moderate-to-severe Crohn's disease

  This study is testing which of three approved treatments works best to help people with moderate-to-severe Crohn's disease feel better and stay off steroids for a year.

  Recruiting at 20 sites Phase 4 University of Calgary · Calgary, Alberta and 22 other locations · NCT05928039

• Registry of Infliximab for Children with Crohn's Disease in China

  This study is testing how well Infliximab works and how safe it is for children aged 6 to 17 with moderate to severe Crohn's disease in China.

  Recruiting Phase 4 Taizhou Mabtech Pharmaceutical Co.,Ltd · Beijing · NCT05906576

• Evaluating sleep changes in patients with inflammatory bowel diseases.

  This study is trying to see if better sleep can help people with inflammatory bowel diseases, like Crohn's and ulcerative colitis, avoid flare-ups.

  Recruiting Hospices Civils de Lyon · Clermont-Ferrand and 3 other locations · NCT05835973

• Using Cellvizio to assess surgical margins in Crohn's disease

  This study is testing if a special imaging tool called Cellvizio can help surgeons see hidden inflammation during surgery for Crohn's disease, so they can make better decisions about how much tissue to remove and reduce the chances of problems later on.

  Recruiting Centre Hospitalier Universitaire, Amiens · Amiens · NCT05805020

• Investigating how ustekinumab distributes in inflamed tissues for Crohn's disease and psoriasis

  This study is testing how well the drug ustekinumab works in people with Crohn's disease and psoriasis who haven't found relief from other treatments by looking at where the drug goes in their inflamed tissues.

  Recruiting Phase 1 University Medical Center Groningen · Groningen · NCT05725876

• Peer mentoring program for managing psychological distress in IBD patients

  This study tests whether a peer mentoring program can help adults with inflammatory bowel diseases feel better mentally during tough times like being newly diagnosed or facing surgery.

  Recruiting Nova Scotia Health Authority · Halifax, N.S. · NCT05722236

• Evaluating early immunological characteristics of inflammatory bowel disease

  This study is trying to learn more about how inflammatory bowel disease develops in people who were recently diagnosed during cancer screening and will follow them for 10 years to see how their condition changes over time.

  Recruiting at 6 sites Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa · Santiago de Compostela, A Coruña and 24 other locations · NCT05698745

• Personalized infliximab dosing for Crohn's disease treatment

  This study is testing whether a computer program that customizes infliximab doses based on blood tests can help people with Crohn's disease feel better compared to the usual dosing methods.

  Recruiting at 11 sites Phase 2/3 Children's Hospital Medical Center, Cincinnati · Los Angeles, California and 10 other locations · NCT05660746

• Comparing two surgical methods for Crohn's disease treatment

  This study is testing which of two surgical methods works better for treating Crohn's disease in patients needing bowel surgery to see which one leads to fewer problems after the operation.

  Recruiting Jinling Hospital, China · Nanjing, Jiangsu · NCT05658081

• Identifying Prognostic Factors in Inflammatory Bowel Disease

  This study is trying to find out which signs and markers can help predict how inflammatory bowel disease will progress in people with Crohn's disease and ulcerative colitis.

  Recruiting Seoul National University Bundang Hospital · Seongnam-si, Gyeonggi-do · NCT05653011

• Comparing hand-sewn and stapled methods for ileocolic surgery in Crohn's disease

  This study is testing whether hand-sewn or stapled methods for surgery can lead to better recovery and fewer flare-ups in patients with Crohn's disease.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Almere Stad, Flevoland · NCT05578235

• Diet plan for Crohn's disease patients after bowel surgery

  This tests a new, China-adapted dietary plan based on enteral nutrition to help people with Crohn's disease stay in remission after bowel surgery.

  Recruiting Second Affiliated Hospital, Zhejiang University, School of Medicine · Hangzhou, Zhejiang · NCT05502965

• Using neurotechnology to treat Crohn's disease after surgery

  This study is testing if a device that stimulates the vagus nerve can help prevent Crohn's disease from coming back in patients who have just had surgery for it.

  Recruiting Austin Health · Melbourne, Victoria · NCT05469607

• Comparing surgery and biologics for treating stricturing Crohn's disease

  This study is testing whether surgery or biologic treatments work better for people with stricturing Crohn's disease who haven't found relief with regular medications.

  Recruiting Jinling Hospital, China · Nanjing, Jiangsu · NCT05421455

• Evaluating Ustekinumab for Treating Stricturing Crohn's Disease

  This study is testing if ustekinumab can help people with moderate-to-severe Crohn's disease who have blockages in their intestines feel better over a two-year period.

  Recruiting at 8 sites Second Affiliated Hospital, Zhejiang University, School of Medicine · Beijing, Beijing Municipality and 7 other locations · NCT05387031

• Personalized Crohn's risk estimator (PRE-Crohn's) implementation and feasibility

  This project will test a web-based personalized risk tool to see if giving unaffected first-degree relatives of people with Crohn's disease tailored risk information changes their behaviors and early disease markers.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05332639

• Using fecal microbiota transplantation to treat active Crohn's disease in children

  This study is testing whether a new treatment using fecal microbiota transplantation along with a special diet can help children with newly diagnosed Crohn's disease feel better compared to a traditional treatment with medications.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT05321758

• Fecal microbiota transplantation for children with Crohn's disease

  This study is testing if a new treatment using fecal microbiota transplantation can help children aged 2-16 with tough-to-treat Crohn's disease feel better and improve their gut health.

  Recruiting Tongji Hospital · Wuhan, Hubei · NCT05321745

• Creating 3D models of the intestine from biopsy samples

  This study is trying to create 3D models of the intestine from biopsy samples to help understand digestive diseases better and find new treatments.

  Recruiting Rennes University Hospital · Rennes · NCT05294107

• Switching treatments for better endoscopic remission in IBD patients

  This study is testing if switching to a different medication can help people with inflammatory bowel disease who have some inflammation while feeling better, compared to sticking with their current treatment.

  Recruiting at 19 sites Mayo Clinic · Scottsdale, Arizona and 23 other locations · NCT05230173

• Comparing two methods of biological therapy to prevent Crohn's disease recurrence after surgery

  This study is testing whether a new way of giving biological therapy during endoscopy can help prevent Crohn's disease from coming back after surgery, compared to the usual method, for people who have had their intestines operated on.

  Recruiting at 24 sites Phase 4 Universitaire Ziekenhuizen KU Leuven · Antwerp, Antwerpen and 27 other locations · NCT05169593

• Combining treatments for children with Crohn's disease

  This study is testing whether combining two treatments for Crohn's disease can help children feel better compared to using just one of the treatments alone.

  Recruiting Phase 4 Children's Hospital of Fudan University · Shanghai, Shanghai Municipality · NCT05043870

• Comparing Azathioprine and Methotrexate with Adalimumab for Crohn's Disease

  This study is testing whether adding azathioprine or methotrexate to adalimumab helps people with Crohn's disease who haven't improved with other treatments.

  Recruiting Phase 3 Centre Hospitalier Universitaire, Amiens · Amiens · NCT05040464

• Using fecal microbiota transplantation to maintain remission in Crohn's disease after stopping anti-TNF treatment

  This study is testing if a stool transplant can help keep people with Crohn's disease in remission after they stop using a certain medication.

  Recruiting Phase 3 Assistance Publique - Hôpitaux de Paris · Paris · NCT04997733

• Evaluating MRI's role in managing Crohn's disease with biotherapy

  This study is testing if adding MRI scans to the treatment plan helps people with Crohn's disease on biotherapy feel better and heal more effectively compared to standard follow-ups.

  Recruiting University Hospital, Clermont-Ferrand · Amiens and 16 other locations · NCT04973423

• Restoring gut bacteria in patients with Crohn's disease

  This study is testing whether a treatment using healthy gut bacteria can help people with active Crohn's disease feel better.

  Recruiting Phase 1/2 St Vincent's Hospital Melbourne · Melbourne, Victoria · NCT04970446

• Using capsule fecal microbiota transplantation to treat newly diagnosed chronic inflammatory diseases

  This study is testing if taking capsules containing healthy gut bacteria can help people recently diagnosed with chronic inflammatory diseases feel better.

  Recruiting Phase 2 Odense University Hospital · Odense · NCT04924270

• Investigating inflammation in Crohn's disease after balloon treatment

  This study is trying to see how balloon treatment for stricturing Crohn's disease affects inflammation in both kids and adults before and after the procedure.

  Recruiting Shaare Zedek Medical Center · Jerusalem · NCT04803916

• Educational tool for melanoma patients with autoimmune diseases

  This study is testing a new educational tool to help melanoma patients with autoimmune diseases understand their treatment options better and see how easy it is for them to use.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT04751396

• Measuring threonine needs in adult males with Crohn's disease

  This study is trying to find out how much threonine adult men with Crohn's disease need compared to healthy young adults.

  Recruiting The Hospital for Sick Children · Toronto, Ontario · NCT04740541

• Using fecal microbiota transplantation to help patients with postoperative Crohn's disease

  This study is testing whether fecal microbiota transplantation can help people with Crohn's disease avoid complications after surgery.

  Recruiting at 2 sites Tampere University Hospital · Tampere and 1 other locations · NCT04637438

• Registry and biorepository for patients with inflammatory bowel diseases in Central Texas

  This study is trying to create a database and collection of samples from people with inflammatory bowel diseases like Crohn's and ulcerative colitis to help future research on these conditions.

  Recruiting University of Texas at Austin · Austin, Texas · NCT04617184

• Evaluating bone health in adolescents with Crohn disease

  This study is trying to see how Crohn disease affects bone health in teenagers by comparing their bone density and marrow fat to those of healthy teens.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT04508088

• Assessing the long-term safety of ustekinumab compared to other biologics for Crohn's disease and ulcerative colitis

  This study is testing how safe the drug ustekinumab is compared to other biologic treatments for adults with Crohn's disease or ulcerative colitis over the long term.

  Recruiting Janssen Scientific Affairs, LLC · Houston, Texas · NCT04372108

• High dose vitamin D for young patients with inflammatory bowel disease on biologic therapy

  This study is testing if giving high doses of vitamin D to young people with inflammatory bowel disease who are on biologic treatments can improve their bone health and reduce inflammation.

  Recruiting Boston Children's Hospital · Boston, Massachusetts · NCT04331639

• Comparing surgical and endoscopic treatments for new stenosis in Crohn's disease

  This study is testing whether surgery or a less invasive balloon treatment works better for people with new blockages in their intestines caused by Crohn's disease.

  Recruiting at 5 sites Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa · Badalona, Barcelona and 15 other locations · NCT04330846

• Low dose IL-2 treatment for Crohn's disease

  This study is testing whether a low-dose treatment with a drug called IL-2 can help people with moderate-to-severe Crohn's disease feel better when other treatments haven't worked.

  Recruiting at 3 sites Phase 1/2 Boston Children's Hospital · Boston, Massachusetts and 2 other locations · NCT04263831

• High dose immunoablation followed by stem cell transplantation for Crohn's disease

  This study is testing whether a high dose of immune treatment followed by a stem cell transplant can help people with severe Crohn's disease who haven't found relief from regular treatments.

  Recruiting Phase 1/2 Cedars-Sinai Medical Center · Los Angeles, California · NCT04224558

• Optimizing treatment for anal suppurations in Crohn's disease

  This study is testing different treatment options for people with Crohn's disease who have anal abscesses to see which ones work best for healing and improving their health over a year.

  Recruiting Rennes University Hospital · Rennes · NCT04192825

• Understanding chronic inflammatory systemic diseases and their treatments

  This study looks at patients with chronic inflammatory diseases to see how these conditions are related and how they can be treated better.

  Recruiting Centre Hospitalier Universitaire de Besancon · Besançon · NCT04191395

• Acupuncture for treating mild to moderate Crohn's disease

  This study is testing whether acupuncture can help people with mild to moderate Crohn's disease feel better by looking at their symptoms and brain activity.

  Recruiting at 2 sites Shanghai Institute of Acupuncture, Moxibustion and Meridian · Shanghai, Shanghai Municipality and 1 other locations · NCT04187820

• Using fecal microbiota transplantation to treat gut disorders

  This study is testing whether a treatment that involves using healthy stool to help restore gut bacteria can improve symptoms for people with gut disorders like Crohn's disease and irritable bowel syndrome.

  Recruiting Chinese University of Hong Kong · Hong Kong, Shatin · NCT04014413

• Using fat-derived stem cells to treat stubborn perianal fistulas in Crohn's disease patients

  This study is testing if injections of fat-derived stem cells can help heal stubborn perianal fistulas in people with Crohn's disease who haven't found relief with regular treatments.

  Recruiting Phase 2 Assistance Publique Hopitaux De Marseille · Marseille, PACA · NCT04010526

• Identifying gut bacteria linked to spondyloarthritis in Crohn's disease patients

  This study is trying to find out if certain gut bacteria are linked to spondyloarthritis in people who have Crohn's disease by comparing them to healthy individuals and those with just one of the conditions.

  Recruiting at 2 sites Central Hospital, Nancy, France · Nancy, Lorraine and 1 other locations · NCT03983473

• Assessing pancreatic insufficiency in patients with active Crohn's disease

  This study looks at how common pancreatic problems are in people with active Crohn's disease before and after starting treatment to see how it affects their health.

  Recruiting Hospices Civils de Lyon · Pierre-Bénite · NCT03915262

• Using nivolumab to treat patients with autoimmune disorders and advanced cancer

  This study is testing if nivolumab can safely help people with autoimmune disorders who also have advanced cancer by looking at how well it works and what side effects it might cause.

  Recruiting at 40 sites Phase 1 National Cancer Institute (NCI) · Birmingham, Alabama and 51 other locations · NCT03816345

• Identifying biomarkers in inflammatory bowel disease

  This study is trying to find specific markers in people with Crohn's disease and ulcerative colitis that can help predict how their disease will progress and how well they will respond to new treatments.

  Recruiting Central Hospital, Nancy, France · Vandœuvre-lès-Nancy · NCT03809728

• Evaluating post-operative outcomes in children with Crohn's Disease

  This study is testing whether two different types of medicine can help prevent Crohn's Disease from coming back in children aged 6 to 17 after they have surgery.

  Recruiting Schneider Children's Medical Center, Israel · Petah Tikva, Israel · NCT03681652

• Exploring gut microbiome in patients with inflammatory bowel disease

  This study is trying to understand the gut bacteria in Korean patients with inflammatory bowel diseases to see how these bacteria might relate to their health and genetics.

  Recruiting Kyunghee University Medical Center · Seoul · NCT03589183

• Observing the safety and effectiveness of treatments for children with inflammatory bowel disease

  This study looks at how safe and effective current treatments are for children under 18 with inflammatory bowel disease to help understand their outcomes and any risks involved.

  Recruiting at 2 sites Erasmus Medical Center · Rotterdam and 1 other locations · NCT03571373

• Understanding post-operative outcomes in Crohn's disease after ileocecal resection

  This study is trying to learn more about how surgery for Crohn's disease affects recovery and the chances of the disease coming back by collecting samples and tracking patients after their operation.

  Recruiting at 15 sites Saint-Louis Hospital, Paris, France · Liège and 16 other locations · NCT03458195

• Using stem cell transplants to treat Crohn's disease

  This study is testing whether using stem cell transplants along with immune-suppressing drugs can help people with Crohn's disease who haven't found relief from other treatments.

  Recruiting Phase 2 Icahn School of Medicine at Mount Sinai · New York, New York · NCT03219359

• Follow-up on the safety of ALLO-ASC-CD for Crohn's disease

  This study is checking the safety of a stem cell treatment for Crohn's disease in people who have already tried it in a previous trial, by monitoring them for three years.

  Recruiting Anterogen Co., Ltd. · Seoul and 1 other locations · NCT03183661

• Monitoring pregnancy outcomes for women exposed to Stelara and Tremfya

  This study is tracking pregnancies in women who have used Stelara or Tremfya to see how these medications might affect the health and development of their babies.

  Recruiting University of California, San Diego · La Jolla, California · NCT02103361

Related topics

Quick answers

How many Crohn Disease clinical trials are recruiting right now?

123, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 37 countries. The most sites are in United States (34 trials), France (29 trials), China (20 trials), Canada (16 trials), Italy (13 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 4: 13, Phase 2: 8, Phase 3: 5, Phase 1/2: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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