Evaluating a new treatment for inflammatory bowel diseases using human intestinal models
Evaluation of an Anti-TREM-1 Treatment on an ex Vivo Human Intestinal Model
This study is testing a new treatment for ulcerative colitis and Crohn's disease to see if it can help manage these conditions better.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 60 Years |
| Sex | All |
| Sponsor | Inotrem Industry-sponsored |
| Locations | 1 site (Milan) |
| Trial ID | NCT06580418 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients with ulcerative colitis and Crohn's disease who are under endoscopic surveillance to monitor their disease activity. The main goal is to assess the therapeutic potential of TREM-1 in treating inflammatory bowel diseases. Participants will undergo additional biopsies and blood sample collection to gather data on the treatment's effectiveness. The study aims to provide insights into how TREM-1 can influence disease management in these patients.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 to 60 with active ulcerative colitis or Crohn's disease.
Not a fit: Patients in remission from ulcerative colitis or Crohn's disease will not benefit from this study.
Why it matters
Potential benefit: If successful, this treatment could offer a new therapeutic option for patients suffering from inflammatory bowel diseases.
How similar studies have performed: While this approach is novel, similar studies targeting inflammatory bowel diseases have shown promising results.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients between 18 and 60 years * Signed informed consent * Ulcerative colitis (UC) patients with active disease * Crohn's disease (CD) patients with active disease Exclusion Criteria: * UC or CD patients in remission * Patients between 18 and 60 years without informed consent
Where this trial is running
Milan
- IRCCS San Raffaele — Milan, Italy (Recruiting)
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.