Investigating biomarkers for complications after colorectal surgery

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the role of proteomics, metabolomics, and proteoglycans as predictors of postoperative complications following colorectal surgery and as potential biomarkers for colorectal cancer. It will involve a cohort of 1,000 patients undergoing elective colorectal resections or stoma closures at two centers in Denmark. Blood samples will be collected on postoperative days and analyzed to identify biomarkers that may predict anastomotic leakages, cancer recurrence, and aid in early cancer diagnosis. The study will also explore the association of the APOE genotype with postoperative outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients diagnosed or with suspicion of colorectal cancer or adenoma, inflammatory bowel disease, late complications to colon diverticulosis, colostomy reversal or other diagnoses requiring colorectal resection.
* Patients planned to undergo elective surgical procedures coded as KJFB20-KJFB99, KJFG30-37 or KJGB00-97 according to the Danish modification of the NOMESCO Classification of Surgical Procedures
* Able to speak Danish, English, or other languages where professional interpretation is available
* Able to give informed consent

Exclusion Criteria:

* Patients undergoing synchronous: liver resection (patients undergoing metastasectomies can be included); total gastrectomy or cardia resection; Whipple's procedure or another major pancreatic resection (resections of the pancreatic tail can be included); total or partial nephrectomies or cystectomy
* Patients previously included in the study
* Patients known to be pregnant (pregnancy test not required)
* Non-resident in Denmark

Where it's running

• Nordsjaellands Hospital
  Hillerød, Denmark Recruiting
• Regionshospitalet Viborg
  Viborg, Denmark Not yet recruiting

Study contacts

• Study coordinator: Nanna B Hupfeld, ph.d.
• Email: nanna.baekvang.hupfeld.01@regionh.dk
• Phone: +4548292793

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Collecting samples from patients with colorectal and gastric cancers and non-malignant diseases

  This study is collecting blood and tissue samples from patients with colorectal and gastric cancers, as well as non-cancerous gastrointestinal diseases, to help with future research.

  Recruiting Renmin Hospital of Wuhan University · Wuhan, Hubei · NCT03972956

• Knife-assisted full-thickness resection for rectal lesions in a multicenter setting

  A multicenter study tests knife-assisted full-thickness resection (kFTR) to remove rectal lesions in adults and see how well it works and how safe it is.

  Recruiting University Hospital, Ghent · Ghent · NCT07923682

• Personalized 3D Bioprinted Colorectal Cancer Microenvironment Model

  This study tests patient-derived, 3D-bioprinted cancer models that include tumor, fibroblast, and immune cells to see if they can better predict how colorectal cancer will respond to treatment.

  Recruiting Peking Union Medical College Hospital · Ningbo, Zhejiang · NCT07919418

• Integrated genomic and clinical database for cancer biomarker discovery

  Researchers are building a combined genomic and clinical database at Samsung Medical Center to test biomarkers for cancer diagnosis, treatment choice, and predicting how well treatments work.

  Recruiting Samsung Medical Center · Seoul, Gang-Nam · NCT07911267

• Prehabilitation with Resistance, Aerobic, or Both Before Colorectal Surgery

  Four pre-surgery exercise options (resistance, aerobic, both, or none) will be tested to see which best reduces complications after colorectal cancer surgery.

  Recruiting Semmelweis University · Budapest · NCT07896174

• Liver transplantation for colorectal cancer with liver metastases

  This study follows adults with stage IV colorectal cancer whose disease is limited to the liver and who are getting a liver transplant as part of their cancer care to see how they fare over time.

  Recruiting Pontificia Universidad Catolica de Chile · Santiago, Santiago Metropolitan · NCT07884110

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.