Understanding genetic factors in celiac disease and inflammatory bowel diseases
Celiac and inflammatory bowel diseases: functional post-GWAS approach
This study is looking at how our genes affect celiac disease and inflammatory bowel diseases like ulcerative colitis and Crohn's disease, so we can better understand how to tailor treatments for patients based on their unique genetic makeup.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project ID | NIH-10882758 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular mechanisms underlying celiac disease and inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. By utilizing advanced genomic techniques, including allele-specific DNA methylation, the study aims to identify how genetic variations influence disease severity and treatment responses. Patients will be stratified based on their genetic profiles to improve personalized treatment approaches. The research involves collaboration with experts in clinical aspects of these diseases to ensure comprehensive insights.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with celiac disease or inflammatory bowel diseases who are seeking better management options.
Not a fit: Patients with gastrointestinal disorders unrelated to celiac disease or inflammatory bowel diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for patients with celiac disease and inflammatory bowel diseases.
How similar studies have performed: Previous research has shown promise in using genomic approaches to improve understanding and treatment of autoimmune diseases, indicating potential success for this novel approach.
Where this research is happening
Hackensack, United States
- Hackensack University Medical Center — Hackensack, United States (Active)
Researchers
- Principal investigator: Tycko, Benjamin — Hackensack University Medical Center
- Study coordinator: Tycko, Benjamin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.