Understanding genetic factors in celiac disease and inflammatory bowel diseases
Official title: Celiac and inflammatory bowel diseases: functional post-GWAS approach
Funded at Hackensack University Medical Center · NIH-10882758 · Data updated 2026-11-12
This study is looking at how our genes affect celiac disease and inflammatory bowel diseases like ulcerative colitis and Crohn's disease, so we can better understand how to tailor treatments for patients based on their unique genetic makeup.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hackensack University Medical Center NIH-funded |
| Lab location | 1 site (Hackensack, United States) |
| Project start | August 19, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $833,524 |
| NIH project number | 1R01AI173261-01A1 |
| Project ID | NIH-10882758 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with celiac disease or inflammatory bowel diseases who are seeking better management options.
✕Less likely to help
Patients with gastrointestinal disorders unrelated to celiac disease or inflammatory bowel diseases may not benefit from this research.
What this research studies
This research investigates the genetic and molecular mechanisms underlying celiac disease and inflammatory bowel diseases, such as ulcerative colitis and Crohn's disease. By utilizing advanced genomic techniques, including allele-specific DNA methylation, the study aims to identify how genetic variations influence disease severity and treatment responses. Patients will be stratified based on their genetic profiles to improve personalized treatment approaches. The research involves collaboration with experts in clinical aspects of these diseases to ensure comprehensive insights.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment strategies for patients with celiac disease and inflammatory bowel diseases.
How similar studies have gone: Previous research has shown promise in using genomic approaches to improve understanding and treatment of autoimmune diseases, indicating potential success for this novel approach.
Where this research is happening
-
Hackensack University Medical Center
Hackensack, United States Active
Researchers
- Principal investigator: Tycko, Benjamin — Hackensack University Medical Center
- Study coordinator: Tycko, Benjamin
Related research
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Understanding why some people with inflammatory bowel disease fail therapy
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Celiac and IBD: unlocking how genes influence disease with DNA methylation
A research project aims to use genetic and epigenetic clues to better understand why celiac disease and inflammatory bowel disease affect people differently and how they respond to treatment.
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How genes and DNA changes influence celiac disease and inflammatory bowel disease
This project looks for DNA changes that alter gene activity to help predict risk, severity, and treatment response for people with celiac disease and inflammatory bowel disease.
-
Understanding what triggers inflammation in inflammatory bowel diseases
This study is looking at what causes inflammation in people with Crohn's disease and ulcerative colitis who are feeling really well, to help find ways to keep them healthy and prevent flare-ups in the future.
-
Finding ways to block bacterial enzymes that worsen inflammatory bowel diseases
This project looks for new ways to treat inflammatory bowel diseases like Crohn's and ulcerative colitis by targeting specific enzymes made by gut bacteria.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.