Examining the NUDT15 gene's role in inflammatory bowel disease in Taiwan
The Prevalence and Impacts of Nudix Hydrolase 15 (NUDT15) Gene Variants in Taiwanese Inflammatory Bowel Disease
This study looks at how the NUDT15 gene affects children with inflammatory bowel disease in Taiwan to see if it can help improve their treatment.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 65 (estimated) |
| Ages | 1 Year to 25 Years |
| Sex | All |
| Sponsor | National Taiwan University Hospital Academic / other |
| Locations | 1 site (Taipei) |
| Trial ID | NCT06913998 on ClinicalTrials.gov |
What this trial studies
This observational study focuses on patients diagnosed with inflammatory bowel disease (IBD) at National Taiwan University Children's Hospital. Participants will undergo a blood test to evaluate the NUDT15 gene, which is known to influence the risk of neutropenia when using thiopurines for treatment. The study aims to summarize the prevalence and impacts of NUDT15 gene variants in the context of IBD in Taiwan, analyzing the gene test results alongside other clinical data to improve treatment strategies.
Who should consider this trial
Good fit: Ideal candidates for this study are individuals diagnosed with inflammatory bowel disease who are willing to undergo a blood test for genetic evaluation.
Not a fit: Patients who refuse to participate in the blood test for NUDT15 gene evaluation will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more personalized and safer treatment options for patients with inflammatory bowel disease.
How similar studies have performed: Previous studies have indicated the significance of NUDT15 gene variants in Asian populations, suggesting that this approach is both relevant and potentially impactful.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Participants who are diagnosed with inflammatory bowel disease. Exclusion Criteria: * Participants who refused to have blood test for NUDT15 gene evaluation.
Where this trial is running
Taipei
- National Taiwan University Hospital — Taipei, Taiwan (Recruiting)
Study contacts
- Study coordinator: Wei-Ting Chen, MD
- Email: DBE98@tepch.gov.tw
- Phone: +886-2-2312-3456
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.