Condition

Colitis, Ulcerative clinical trials and research

• 31Clinical trials
• 47Countries

Newest Colitis, Ulcerative clinical trials

All recruiting trials (31)

• Intestinal ultrasound-guided management for inflammatory bowel disease

  This study tests if adding point-of-care intestinal ultrasound at every visit changes treatment decisions for adults with Crohn’s disease or ulcerative colitis undergoing disease assessment.

  Recruiting Mahidol University · Bangkok · NCT07775352

• Aletekitug safety study in moderate to severe ulcerative colitis

  This sub-study tests whether aletekitug, an anti-IL-18 medication, is safe and tolerable for people with moderately to severely active ulcerative colitis.

  Recruiting Phase 1 GlaxoSmithKline · Oxford · NCT07747480

• Treatment study to test multiple interventions for moderate to severe ulcerative colitis

  This study tests whether a single master protocol can safely test the anti-IL-18 treatment Aletekitug (GSK1070806) in adults with moderate to severe ulcerative colitis to see if it is tolerable and potentially beneficial.

  Recruiting Phase 1 GlaxoSmithKline · Oxford · NCT07747467

• Characterization of Colorectal Dysplastic Lesions and Changes in Risk in IBD Patients

  This study tests how colorectal dysplastic lesions in adults with Crohn disease or ulcerative colitis change over time to help tailor screening and treatment.

  Recruiting at 2 sites Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives · Amiens and 1 other locations · NCT07719426

• Resting energy use in kids with inflammatory bowel disease

  This multicenter study will test the resting energy expenditure of children aged 6–17 with new IBD diagnoses to see how it relates to disease activity and treatment.

  Recruiting Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria · Alessandria, Piedmont · NCT07670975

• Guselkumab in Breast Milk for Lactating Women on Guselkumab

  This study tests how much guselkumab is present in the breast milk of lactating women who are already receiving guselkumab for their approved conditions.

  Recruiting Phase 4 Janssen Research & Development, LLC · Chapel Hill, North Carolina · NCT07654751

• Guselkumab use in Crohn's disease and ulcerative colitis

  This study looks at how long people with moderate-to-severe Crohn's disease or ulcerative colitis stay on guselkumab in real-world care.

  Recruiting Janssen-Cilag Pharma GmbH · Vienna · NCT07606339

• Test of JNJ-78934804 vs guselkumab in moderately to severely active ulcerative colitis

  This study tests JNJ-78934804 against guselkumab to see which helps people with moderately to severely active ulcerative colitis feel better and stay safe over 48 weeks.

  Recruiting at 318 sites Phase 3 Janssen Research & Development, LLC · Scottsdale, Arizona and 317 other locations · NCT07577856

• Real-world use of guselkumab in Crohn’s disease and ulcerative colitis

  This study tests how long guselkumab stays in the bodies of adults with moderate-to-severe Crohn’s disease or ulcerative colitis treated in real-world clinical settings.

  Recruiting Janssen-Cilag A.G., Switzerland · Bern · NCT07532213

• New treatments for adults with ulcerative colitis or Crohn's disease

  This study tests new treatments for adults with moderately to severely active ulcerative colitis or Crohn's disease to see if they work and are safe.

  Recruiting at 55 sites Phase 2 Eli Lilly and Company · Scottsdale, Arizona and 70 other locations · NCT07483073

• Etrasimod treatment for children with moderately to severely active ulcerative colitis

  This trial tests whether the medicine etrasimod is safe and helps children ages 2 to under 12 with moderately to severely active ulcerative colitis.

  Recruiting at 45 sites Phase 2 Pfizer · Indianapolis, Indiana and 45 other locations · NCT07470879

• MK-8690 for moderately to severely active ulcerative colitis

  This trial will test whether the investigational drug MK-8690 can help adults with moderate to severe ulcerative colitis reach clinical remission by week 12.

  Recruiting at 39 sites Phase 2 Merck Sharp & Dohme LLC · Anaheim, California and 38 other locations · NCT07463183

• Magnesium status in people with IBD, ileostomy, or bile acid diarrhea

  This will test different ways to check magnesium in adults with Crohn's disease, ulcerative colitis, ileostomies, or bile acid diarrhea to see which method best finds deficiency.

  Recruiting University of Aarhus · Aarhus N · NCT07338565

• Guselkumab for Chinese patients with moderate-to-severe ulcerative colitis in routine care

  This project will try guselkumab in Chinese adults with moderate-to-severe ulcerative colitis who have never used biologic therapies to see how their symptoms, endoscopic appearance, and quality of life change in routine clinical care.

  Recruiting at 11 sites Xian-Janssen Pharmaceutical Ltd. · Beijing and 10 other locations · NCT07302360

• MH002 treatment for active ulcerative colitis

  This trial will test whether two doses of the live bacterial medicine MH002 are safe and help people with active mild-to-moderate ulcerative colitis.

  Recruiting at 49 sites Phase 2 MRM Health NV · Miami, Florida and 48 other locations · NCT07296315

• Real-world use of guselkumab for adults with moderate-to-severe ulcerative colitis and Crohn's disease in the UK

  This project will see how well guselkumab works for adults with moderate-to-severe ulcerative colitis or Crohn's disease who are starting the treatment in routine UK care.

  Recruiting Janssen-Cilag Ltd. · Harrow · NCT07242248

• Guselkumab treatment for Crohn's disease and ulcerative colitis in Germany

  This project will try to see how well guselkumab works and how it affects symptoms, quality of life, and daily activities for adults with Crohn's disease or ulcerative colitis receiving routine care in Germany.

  Recruiting Janssen-Cilag G.m.b.H · Berlin · NCT07102368

• Long-acting antibody treatments alone and in combinations for moderate to severe ulcerative colitis

  This tests long-acting antibody medicines, given after an IV induction and then as under-the-skin maintenance, to see if they help adults with moderate to severe ulcerative colitis.

  Recruiting at 276 sites Phase 2 Spyre Therapeutics, Inc. · Canoga Park, California and 275 other locations · NCT07012395

• Examining the link between polyamine levels and inflammatory bowel disease progression

  This study is trying to see if measuring certain substances in the body can help predict how inflammatory bowel diseases like Ulcerative Colitis and Crohn's Disease will progress in patients.

  Recruiting Xijing Hospital · Xi'an, Shaanxi · NCT06995170

• Using advanced imaging to assess inflammation in bowel diseases

  This study is testing if a new imaging technique can help doctors better see inflammation in patients with Inflammatory Bowel Disease compared to the standard method.

  Recruiting University of Ulm · Ulm, Baden-Wurttemberg · NCT06892990

• Long-term evaluation of guselkumab for children with inflammatory bowel disease and juvenile arthritis

  This study tests how safe and effective the medication guselkumab is for children with inflammatory bowel disease or juvenile arthritis over a long period of time.

  Recruiting at 53 sites Phase 3 Janssen Research & Development, LLC · Atlanta, Georgia and 52 other locations · NCT06663332

• Upadacitinib-first versus infliximab-only rescue strategy for adults with steroid-refractory acute severe ulcerative colitis.

  This trial tests whether giving upadacitinib first and switching to infliximab only if needed works as well as starting with infliximab alone for adults hospitalized with steroid-refractory acute severe ulcerative colitis.

  Recruiting Phase 3 McMaster University · Hamilton, Ontario · NCT06660693

• Long-term safety and effectiveness of tulisokibart for Crohn's disease and ulcerative colitis

  This study is testing if the medication tulisokibart is safe and effective for people with moderate to severe Crohn's disease and ulcerative colitis over a longer period of time.

  Recruiting at 34 sites Phase 3 Merck Sharp & Dohme LLC · Bristol, Connecticut and 36 other locations · NCT06651281

• Observing the effects of etrasimod in adults with moderate to severe ulcerative colitis

  This study is testing how well etrasimod works for adults with moderate to severe ulcerative colitis by tracking their symptoms over a year while they use the medication as part of their regular treatment.

  Recruiting at 24 sites Pfizer · Mesa, Arizona and 28 other locations · NCT06398626

• Exploring sleep disorders in ulcerative colitis patients

  This study looks at how sleep problems affect people with ulcerative colitis and what that means for their overall health and gut bacteria.

  Recruiting Xijing Hospital · Xi'an, Shaanxi · NCT06359808

• Evaluating the safety and effectiveness of Jyseleca tablet in Korean patients

  This study is testing how safe and effective the Jyseleca tablet is for Korean patients with rheumatoid arthritis and ulcerative colitis who haven't found relief with other treatments.

  Recruiting at 57 sites Eisai Inc. · Cheonan, Chungcheongnam-do and 58 other locations · NCT06246123

• Evaluating inflammation in children with inflammatory bowel disease

  This study is testing a new device to see how it can help doctors understand inflammation in children with Crohn's disease and ulcerative colitis, so they can provide better treatment.

  Recruiting Children's National Research Institute · Washington D.C., District of Columbia · NCT06065228

• Investigating Ozanimod for Children with Moderate to Severe Ulcerative Colitis

  This study is testing a new oral medication called ozanimod to see if it can help children with moderate to severe ulcerative colitis feel better and stay well after other treatments haven't worked.

  Recruiting at 41 sites Phase 2/3 Bristol-Myers Squibb · Phoenix, Arizona and 90 other locations · NCT05076175

• Phentermine‑topiramate to help obese adults with active ulcerative colitis

  This trial will test whether the weight‑loss medicine phentermine‑topiramate helps obese adults with active ulcerative colitis lose weight and improve their response to biologic treatment over 22 weeks.

  Recruiting Phase 2 University of California, San Diego · La Jolla, California · NCT04721873

• Assessing the long-term safety of ustekinumab compared to other biologics for Crohn's disease and ulcerative colitis

  This study is testing how safe the drug ustekinumab is compared to other biologic treatments for adults with Crohn's disease or ulcerative colitis over the long term.

  Recruiting Janssen Scientific Affairs, LLC · Houston, Texas · NCT04372108

• Sustainable diet to shift gut microbes and lower ulcerative colitis activity

  This project will try a sustainable non-elemental diet in adults with mild to moderately active ulcerative colitis to change gut bacteria and reduce disease activity.

  Recruiting Mount Sinai Hospital, Canada · Toronto, Ontario · NCT04121806

Related topics

Quick answers

How many Colitis, Ulcerative clinical trials are recruiting right now?

31, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 47 countries. The most sites are in United States (13 trials), Germany (9 trials), Poland (9 trials), United Kingdom (9 trials), Canada (8 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 6, Phase 3: 4, Phase 1: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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