Understanding what triggers inflammation in inflammatory bowel diseases
Determinants of inception of inflammation in inflammatory bowel diseases
This study is looking at what causes inflammation in people with Crohn's disease and ulcerative colitis who are feeling really well, to help find ways to keep them healthy and prevent flare-ups in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11134568 on NIH RePORTER |
What this research studies
This research investigates the underlying factors that lead to inflammation in patients with Crohn's disease and ulcerative colitis. By focusing on a specific group of patients in deep remission, the study aims to identify microbial, metabolic, and genetic changes that may predict relapse. The approach involves comprehensive profiling of biological samples over time to uncover the mechanisms behind inflammation onset. This could lead to better-targeted therapies and interventions to maintain remission.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Crohn's disease or ulcerative colitis who are currently in deep remission.
Not a fit: Patients with active inflammation or those who have not been diagnosed with inflammatory bowel diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that help maintain remission in patients with inflammatory bowel diseases.
How similar studies have performed: Other research has shown promise in understanding inflammatory bowel diseases through similar profiling approaches, indicating potential for success in this study.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Ananthakrishnan, Ashwin N — Massachusetts General Hospital
- Study coordinator: Ananthakrishnan, Ashwin N
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.