Using Metformin to Treat Ulcerative Colitis
Official title: Metformin, The Biguanide Derivative, as Adjuvant Therapy in Patients With Ulcerative Colitis Treated With Mesalamine
Run by Tanta University · NCT05574387 · Data updated 2026-11-12
This study is testing if adding Metformin to the treatment plan can help adults with mild to moderate ulcerative colitis feel better.
Quick facts
| Phase | Phase 2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Enrollment | 46 (estimated) |
| Sponsor | Tanta University Academic / other |
| Locations | 1 site (Al Mansurah) |
| Status | Recruiting |
| Started | January 20, 2023 |
| Main results expected | December 2026 |
| Study ends | April 2027 |
| Registry record updated | March 4, 2025 |
| Trial ID | NCT05574387 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older with mild to moderate ulcerative colitis.
✕Probably not a fit
Patients with severe ulcerative colitis or those with significant liver or kidney function abnormalities may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This clinical trial investigates the use of Metformin as an additional therapy for patients suffering from ulcerative colitis, a chronic inflammatory bowel disease. The study aims to explore the potential benefits of Metformin in improving treatment outcomes for patients with mild to moderate forms of the condition. Participants will be adults aged 18 and older who have been diagnosed with ulcerative colitis and meet specific inclusion criteria. The trial will exclude individuals with severe disease or other significant health issues that could interfere with the study.
Why it matters
Potential benefit: If successful, this approach could provide a new therapeutic option for patients with ulcerative colitis, potentially improving their quality of life.
How similar studies have gone: While the use of Metformin in inflammatory bowel diseases is an emerging area, there is limited prior research specifically targeting ulcerative colitis, making this approach relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Age ≥ 18 years Both males and females will be included Negative pregnancy test and effective contraception Mild and moderate UC patients diagnosed and confirmed by the endoscope Exclusion Criteria: \- Breastfeeding Significant liver and kidney function abnormalities Diabetic patients Colorectal cancer patients Patients with severe UC Patients taking rectal or systemic steroids
Where it's running
-
Faculty of Medicine, Mansoura University
Al Mansurah, Egypt Recruiting
Study contacts
- Study coordinator: Mostafa Bahaa, PhD
- Email: mbahaa@horus.edu.eg
- Phone: 0201025538337
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.