Clinical trial Recruiting at 1 site Phase 2 Interventional Ages 18 to 75

Using Metformin to Treat Ulcerative Colitis

Official title: Metformin, The Biguanide Derivative, as Adjuvant Therapy in Patients With Ulcerative Colitis Treated With Mesalamine

Run by Tanta University · NCT05574387 · Data updated 2026-11-12

This study is testing if adding Metformin to the treatment plan can help adults with mild to moderate ulcerative colitis feel better.

Quick facts

PhasePhase 2
Study typeInterventional
Ages18 Years to 75 Years
SexAll
Enrollment46 (estimated)
SponsorTanta University
Academic / other
Locations1 site (Al Mansurah)
StatusRecruiting
StartedJanuary 20, 2023
Main results expectedDecember 2026
Study endsApril 2027
Registry record updatedMarch 4, 2025
Trial IDNCT05574387 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults aged 18 and older with mild to moderate ulcerative colitis.

Probably not a fit

Patients with severe ulcerative colitis or those with significant liver or kidney function abnormalities may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the use of Metformin as an additional therapy for patients suffering from ulcerative colitis, a chronic inflammatory bowel disease. The study aims to explore the potential benefits of Metformin in improving treatment outcomes for patients with mild to moderate forms of the condition. Participants will be adults aged 18 and older who have been diagnosed with ulcerative colitis and meet specific inclusion criteria. The trial will exclude individuals with severe disease or other significant health issues that could interfere with the study.

Why it matters

Potential benefit: If successful, this approach could provide a new therapeutic option for patients with ulcerative colitis, potentially improving their quality of life.

How similar studies have gone: While the use of Metformin in inflammatory bowel diseases is an emerging area, there is limited prior research specifically targeting ulcerative colitis, making this approach relatively novel.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

\- Age ≥ 18 years Both males and females will be included Negative pregnancy test and effective contraception Mild and moderate UC patients diagnosed and confirmed by the endoscope

Exclusion Criteria:

\- Breastfeeding Significant liver and kidney function abnormalities Diabetic patients Colorectal cancer patients Patients with severe UC Patients taking rectal or systemic steroids

Where it's running

  • Faculty of Medicine, Mansoura University
    Al Mansurah, Egypt
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.