Personalized dietary fiber recommendations for patients with inflammatory bowel disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study examines how well patients with inflammatory bowel diseases, specifically ulcerative colitis, tolerate personalized dietary fiber recommendations. Participants will be assigned to different diet groups, including high-pectin and high-B-fructan diets, based on their individual responses. The dietary plans are developed by an IBD dietician and aim to improve patient outcomes through tailored nutrition. The study will involve children and young adults who are in remission or have mild to moderate disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Children (age 6-17) or young adults (age 18-39).
* Known or suspected UC or IBDU \[there will be 2 control group: non-IBD (undergoing colonoscopy but found not to have IBD; and healthy (no GI symptoms, so not required to have colonoscopy; could be family members)\]
* For UC: Remission-mild-moderate disease: Mayo score \<10
* Clinical indication for sedated colonoscopy
* Disease location: E2-E4
* Stable treatment (not on steroids; biologics or immunomodulator not changed in last month)
* High likelihood that patients will be able to collect all samples and provide all data

Exclusion Criteria:

* Use of antibiotics for a week or more over the last 3 months
* Use of probiotics or prebiotics at pharmacological doses (adding fibre sources to food or probiotics in yogurt, for example, are allowed)
* History of abdominal surgery, including appendectomy
* Documented enteric infection during the 3 months prior to endoscopy
* Presence of non-IBD bowel conditions (e.g., celiac), anatomical or mucosal abnormalities, motility disorder
* Presence of a systemic disease requiring treatment (cancer, ischemic heart disease, kidney failure, etc)
* Proctitis (E1)
* Systemic steroids (above 10 mg/day of Prednisone)
* Topical therapy within 1 week of endoscopy
* Recent change in IBD treatment (started biologics or IM over the last month)
* Pregnancy or planning to become pregnant during the study
* Inability to understand or sign the consent

Where it's running

• University of Alberta Hospital
  Edmonton, Alberta, Canada Recruiting
• Health Sciences Centre Hospital
  Winnipeg, Manitoba, Canada Recruiting

Study contacts

• Study coordinator: Heather Armstrong, MSc, PhD
• Email: heather.armstrong@umanitoba.ca
• Phone: 2047893815

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Long-acting antibody treatments alone and in combinations for moderate to severe ulcerative colitis

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• Observational study comparing inflammatory markers in IBD and non-IBD participants

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• Evaluating robotic surgery for inflammatory bowel disease

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  Recruiting at 6 sites University Hospitals Coventry and Warwickshire NHS Trust · Coventry, West Midlands and 5 other locations · NCT06579443

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.