Condition

Amyloidosis clinical trials and research

• 29Clinical trials
• 36NIH research projects
• 25Countries

Newest Amyloidosis clinical trials

All recruiting trials (29)

• Acoramidis for ATTR-CM: Cardiac Imaging Study

  This study tests whether acoramidis can improve heart structure and function in people with transthyretin amyloid cardiomyopathy.

  Recruiting Phase 4 Eidos Therapeutics, a BridgeBio company · St Louis, Missouri · NCT07695701

• Heart-Healthy Rehab for Cardiac Amyloidosis

  This study tests whether a 5-week supervised cardiac rehabilitation program can help people with cardiac amyloidosis improve exercise capacity and quality of life.

  Recruiting University Hospital, Montpellier · Montpellier · NCT07494942

• SCTC21C plus bortezomib, cyclophosphamide and dexamethasone for newly diagnosed systemic light-chain (AL) amyloidosis

  This trial tests whether adding SCTC21C to standard bortezomib‑cyclophosphamide‑dexamethasone (VCd) helps people with newly diagnosed AL (light‑chain) amyloidosis achieve better hematologic responses and outcomes.

  Recruiting Phase 3 Sinocelltech Ltd. · Beijing, Beijing Municipality · NCT07388602

• In-home cancer treatment with remote specialist support for patients in the Florida Panhandle

  This program will try giving standard cancer treatments at home to people living in the Florida Panhandle and nearby areas to see if they prefer it and have better treatment satisfaction.

  Recruiting Phase 2 Mayo Clinic · Jacksonville, Florida · NCT07285044

• 18F‑FT8 PET imaging for light‑chain (AL) cardiac amyloidosis

  This project tests whether a new PET tracer, 18F‑FT8, can safely and clearly image light‑chain (AL) cardiac amyloidosis in adults with suspected or known disease and in healthy volunteers.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT07232459

• Belantamab Mafodotin with a chemotherapy combo for newly diagnosed AL amyloidosis

  This study tests whether adding belantamab mafodotin to a regimen of cyclophosphamide, bortezomib, and dexamethasone can help adults with newly diagnosed AL amyloidosis.

  Recruiting at 16 sites Phase 2 GlaxoSmithKline · Los Angeles, California and 15 other locations · NCT07224672

• Magnetocardiography for Cardiac Amyloidosis

  This project tests whether magnetocardiography (MCG) can help diagnose and monitor heart involvement in adults with amyloidosis compared with ECG and other standard tests.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07218705

• Measuring heart stiffness in amyloidosis with cardiac MRI elastography

  This tests whether cardiac MRI elastography can measure heart stiffness in adults with cardiac amyloidosis compared with people without the condition.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT07216469

• Belgian Amyloidosis Biobank and Patient Registry at UZ Leuven

  This project collects and stores blood, tissue samples, and medical data from adults with suspected or confirmed amyloidosis to create a biobank and registry for future research.

  Recruiting at 2 sites Universitaire Ziekenhuizen KU Leuven · Leuven and 1 other locations · NCT07172243

• Pan-amyloid PET/CT scans to find amyloid deposits in adults

  This project tests whether PET/CT scans using amyloid tracers can find amyloid deposits in adults with suspected or known amyloidosis, including heart involvement.

  Recruiting at 3 sites Tianjin Medical University · Hefei, Anhui and 2 other locations · NCT07130565

• Dual-target CAR T therapy (CD19 and BCMA) for relapsed or refractory AL (light-chain) amyloidosis

  This trial will try AZD0120, a CAR T cell therapy that targets CD19 and BCMA, to see if it is safe and helps people with relapsed or refractory AL (light-chain) amyloidosis.

  Recruiting at 15 sites Phase 1/2 Alexion Pharmaceuticals, Inc. · Phoenix, Arizona and 17 other locations · NCT07081646

• Using PET/CT Imaging to Detect Amyloidosis in Patients Treated with Anakinra

  This study is testing a new imaging method to see if it can help find amyloidosis in adults with cryopyrin-associated periodic syndromes who have been treated with anakinra.

  Recruiting Phase 1 National Institutes of Health Clinical Center (CC) · Bethesda, Maryland · NCT06974877

• Registry for patients with systemic amyloidosis

  This study is collecting information from patients with systemic amyloidosis to better understand the disease and how different treatments work over time.

  Recruiting University Hospital, Essen · Essen, North Rhine-Westphalia · NCT06887283

• Registry for Rare Diseases

  This study is creating a detailed registry to collect information on rare diseases like amyloidosis and sarcoidosis to help improve how they are diagnosed and treated.

  Recruiting Hospital Italiano de Buenos Aires · Buenos Aires, Buenos Aires · NCT06573723

• Preventing transthyretin amyloidosis in young carriers of a genetic variant

  This study is testing if a medication called acoramidis can help prevent transthyretin amyloidosis in young adults who carry a specific genetic variant that puts them at risk for the disease.

  Recruiting at 104 sites Phase 3 Eidos Therapeutics, a BridgeBio company · La Jolla, California and 103 other locations · NCT06563895

• Determining how common amyloidosis is in trauma surgery patients

  This study is trying to find out how common amyloidosis is in patients who are about to have trauma surgery by looking for certain warning signs that might show a higher risk.

  Recruiting Consorci Sanitari de l'Alt Penedès i Garraf · Sant Pere de Ribes, Barcelona · NCT06527521

• Evaluation of heart health in patients with ATTR amyloidosis on tafamidis treatment

  This study looks at how tafamidis treatment affects heart health in patients with ATTR amyloidosis by checking their heart rhythm and other health needs every six months.

  Recruiting Fondazione IRCCS Policlinico San Matteo di Pavia · Pavia · NCT06251778

• Optimizing first-line treatment for AL amyloidosis with specific genetic markers

  This study is testing a new treatment plan for people with AL amyloidosis who have a specific genetic marker to see if it helps them respond better and faster to their first-line therapy.

  Recruiting at 7 sites Peking University People's Hospital · Beijing, Beijing Municipality and 6 other locations · NCT06192979

• Investigating the link between unexplained polyneuropathy and wild-type TTR cardiac amyloidosis

  This study is trying to see if people with unexplained nerve problems might also have a heart condition called wild-type TTR cardiac amyloidosis to help diagnose them faster.

  Recruiting Universitair Ziekenhuis Brussel · Jette, Belgium Capital City · NCT05950867

• Evaluating Iodine-124 Evuzumitide in Patients with Systemic Amyloidosis

  This study is testing how a new imaging agent called iodine-124 evuzumitide works in people with systemic amyloidosis, especially those with heart issues, to see how it affects their organs and overall health.

  Recruiting Phase 2 Oregon Health and Science University · Portland, Oregon · NCT05758493

• Using a smartphone app to track diet in amyloidosis patients

  This study is testing whether a smartphone app can help people with amyloidosis track their diet and weight changes over nine weeks.

  Recruiting Barbara Ann Karmanos Cancer Institute · Detroit, Michigan · NCT05738005

• Evaluating the prevalence of transthyretin amyloidosis in heart failure patients

  This study is trying to find out how common transthyretin amyloidosis is in older heart failure patients to help catch it early for better treatment.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT05577819

• Registry for older adults with blood cancers

  This study is creating a registry for older adults with blood cancers to see how their health changes over time and to support future research.

  Recruiting University of Alabama at Birmingham · Birmingham, Alabama · NCT05556928

• Cohort of patients with plasma cell disorders at Peking University First Hospital

  This study is looking at hospitalized patients with plasma cell disorders to see how their treatment and disease status affect their outcomes over time.

  Recruiting Peking University First Hospital · Beijing · NCT05283993

• Testing Belantamab Mafodotin for AL Amyloidosis

  This study is testing a new drug called Belantamab Mafodotin to see if it can safely help people with relapsed or hard-to-treat AL Amyloidosis feel better.

  Recruiting at 2 sites Phase 1/2 University of Texas Southwestern Medical Center · Nashville, Tennessee and 2 other locations · NCT05145816

• Deferring stem cell transplant in newly diagnosed multiple myeloma patients based on minimal residual disease

  This study is testing if newly diagnosed multiple myeloma patients can safely wait on a stem cell transplant until it's clear they have minimal residual disease.

  Recruiting Phase 2 University of Alabama at Birmingham · Birmingham, Alabama · NCT04991103

• Investigating the role of ATTR amyloidosis in patients with aortic stenosis

  This study is trying to see how common a specific type of amyloidosis is in patients with aortic stenosis who are having valve replacement surgery, to better understand its impact on their heart health.

  Recruiting University Hospital, Toulouse · Toulouse · NCT04636684

• Registry for patients with cardiomyopathies

  This study is collecting health information and samples from people with different types of heart muscle diseases to better understand their causes and effects over time.

  Recruiting University Hospital Heidelberg · Heidelberg, Baden-Wurttemberg · NCT04265040

• Registry for adults with plasma cell disorders

  This study is creating a registry for adults with plasma cell disorders like multiple myeloma to track their health and care experiences over time while also collecting blood samples for future research.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT03717844

NIH-funded research (36)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how kidney-like blood flow may cause amyloid buildup

  A research project uses tiny blood-flow devices to study how certain proteins misfold and form amyloid deposits in organs like the kidney and heart.

  NIH research Upstate Medical University · Syracuse, United States · NIH-11408614

• Blood test to detect ATTR amyloidosis earlier using a smart detection kit

  A new blood test kit aims to detect ATTR amyloidosis early using a biomarker that appears in patients but not in healthy people.

  NIH research Amygo Solutions LLC · Grand Prairie, United States · NIH-11407018

• Detection and measurement of amyloid in people carrying the V122I TTR gene variant

  This research will look for early signs of heart-related amyloidosis in people with the V122I TTR gene variant using blood tests and a special imaging scan.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11397680

• Identifying Hidden Cardiac Amyloidosis in Black V122I TTR Carriers

  This project looks for early signs of heart damage in Black individuals who carry the V122I TTR variant and may benefit from new treatments if caught early.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11393304

• Chip phosphorylation boosts breakdown of mutant TTR to help heart amyloidosis

  A scientist-led project aims to help people with a heart disease caused by a mutant protein called transthyretin (TTR) by boosting the body’s protein-cleanup systems to remove the harmful TTR deposits.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11386483

• Finding transthyretin heart amyloid from lumbar spine surgery tissue

  This project looks for transthyretin (TTR) amyloid in tissue removed during lumbar spine surgery to find people who may later develop TTR cardiac amyloidosis.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11374113

• Blood biomarker test for heart amyloidosis in Black and Hispanic people

  A blood test called TAD1 is being checked to detect dangerous heart amyloidosis earlier in Black and Hispanic patients who have heart failure.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11372835

• PET tracer to image cardiac amyloidosis

  A new PET tracer is being developed to help visualize amyloid buildup in the heart, potentially helping people with amyloidosis and related heart disease.

  NIH research Washington University · Saint Louis, United States · NIH-11368737

• Targeting the misfolding of light chain amyloidosis proteins to protect organs

  A patient-facing overview of a project that tests a small molecule to keep light chain proteins from misfolding and causing organ damage in people with amyloidosis.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11364960

• Checking for AL amyloidosis in people with smoldering myeloma

  This project will use blood markers and clinical data to find hidden AL amyloidosis early in people with smoldering multiple myeloma.

  NIH research Tufts Medical Center · Boston, United States · NIH-11294139

• Earlier detection of light-chain (AL) amyloidosis

  This project will use Medicare health records and machine learning to spot early warning patterns so doctors can consider AL amyloidosis sooner for people at risk.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11289334

• Am I ATTRisk? Genomic screening to find hereditary ATTR in African American and Hispanic/Latino adults

  A population-based genomic screening program aims to identify people with the hereditary transthyretin amyloidosis (ATTRv) risk so they can get timely monitoring and care.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11279013

• Why losing parts of the Y chromosome may drive TTR heart amyloidosis in men

  The team is looking at whether loss of the Y chromosome in blood cells helps explain why men develop transthyretin (TTR) heart amyloidosis.

  NIH research University of Virginia · Charlottesville, United States · NIH-11258520

• Best length of daratumumab maintenance for light-chain (AL) amyloidosis

  This project compares shorter (6 months) versus longer (18 months) daratumumab maintenance for people with AL amyloidosis who have responded to daratumumab-CyBorD induction.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11247977

• How transthyretin proteins clump and harm nerves and the heart

  This project looks at how blood flow and mechanical stress cause transthyretin protein to misfold and form damaging clumps in people with amyloidosis.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11239131

• Proteins that stick to amyloid plaques in Alzheimer's

  The team is looking at whether extra proteins that collect with amyloid plaques help cause brain injury in people with Alzheimer's.

  NIH research University of Florida · Gainesville, United States · NIH-11169687

• New Medicines for Light Chain Amyloidosis

  This work looks for new medicines to help stop the harmful protein buildup in people with light chain amyloidosis.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11132076

• Improving outcomes in cardiac amyloidosis using innovative imaging techniques

  This study is looking at new ways to use advanced imaging to improve how we diagnose and treat cardiac amyloidosis, helping doctors create personalized care plans for patients while also training future researchers in this important area.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11127391

• Hidden transthyretin heart amyloid in people with the V122I gene

  This project looks for early signs of transthyretin-related heart amyloid in Black adults who carry the V122I gene change.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11095793

• Boosting CHIP to help clear mutant transthyretin from the heart

  Sees if turning on CHIP and a partner enzyme (PKG) helps heart cells and lab-grown heart tissue clear mutant transthyretin for people with transthyretin cardiac amyloidosis.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11082288

• Understanding the structure of tau proteins linked to Alzheimer's and related diseases

  This study is looking at how tau proteins in the brain clump together and cause problems in diseases like Alzheimer's, with the goal of finding new ways to diagnose and treat these conditions for patients.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11081779

• Personalized exercise training to enhance physical ability in older adults with cardiac amyloidosis

  This study is looking to see if a special 12-week exercise program can help older adults with heart issues from cardiac transthyretin amyloidosis feel stronger and improve their overall quality of life.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11072081

• Identifying early signs of hereditary TTR amyloidosis in high-risk minority groups

  This study is looking at hereditary TTR amyloidosis to find early signs of the disease, especially in African American and Hispanic/Latino communities, so that people can get diagnosed and treated sooner.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11067800

• Investigating the role of Y chromosome loss in heart disease related to amyloidosis

  This study is looking into how losing the Y chromosome in blood cells might be linked to a heart condition called transthyretin cardiac amyloidosis, especially in men, to help find better ways to diagnose and treat this serious issue.

  NIH research University of Virginia · Charlottesville, United States · NIH-11065545

• Understanding how transthyretin proteins misfold and cause diseases

  This study is looking at how certain proteins misbehave in transthyretin amyloidosis, which can cause serious health problems, to understand how they clump together in the body and how things like fluid flow might affect this process, with the hope of finding new ways to treat these conditions.

  NIH research Scripps Research Institute, the · La Jolla, United States · NIH-11050903

• Early detection of hereditary heart amyloid in people with the V122I TTR gene

  This project looks for tiny clumps of transthyretin amyloid in the blood and early heart involvement using a special iodine-124 PET scan in people who carry the V122I TTR variant, a change common in people of African ancestry.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-11048179

• Improving early diagnosis of AL amyloidosis in patients with smoldering multiple myeloma

  This study is looking to find a better way to spot early signs of AL amyloidosis in people with smoldering multiple myeloma, so we can help them avoid serious health issues like heart and kidney problems.

  NIH research Tufts Medical Center · Boston, United States · NIH-11044135

• Evaluating the best duration for maintenance therapy in light chain amyloidosis

  This study is looking at how long patients with light chain amyloidosis should continue taking daratumumab after their initial treatment to see which duration—6 months or 18 months—helps them feel better and live longer.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11034184

• Finding ways to diagnose light chain amyloidosis earlier

  This study is looking to help doctors spot light chain amyloidosis earlier, especially in Black individuals who might not get diagnosed as quickly, by using smart technology to find patterns in earlier health issues that could signal the disease.

  NIH research Medical College of Wisconsin · Milwaukee, United States · NIH-11011349

• Investigating the role of amyloid-associated proteins in Alzheimer's disease

  This study is looking at how certain proteins linked to amyloid buildup in the brain might play a role in causing Alzheimer's disease, with the hope of finding new ways to understand and treat the condition.

  NIH research University of Florida · Gainesville, United States · NIH-10890256

• Investigating how a protein can help reduce heart damage from a genetic mutation

  This study is looking at a heart condition called cardiac amyloidosis, which happens when a protein builds up in the heart, and it's testing a new way to help break down these harmful proteins using a special enzyme, with the hope of finding better treatments for patients like you.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10882087

• How aging and amyloidosis affect timing in the brain and how to improve it

  This study is looking at how aging and a condition linked to Alzheimer's disease affect the brain's timing for making decisions about rewards, and it aims to see if activating certain brain pathways can help improve this timing in mice.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-10875739

• Identifying early signs of heart disease in certain Black individuals

  This study is looking for people with a specific genetic variant linked to hereditary cardiac amyloidosis to find early signs of heart issues using special imaging and blood tests, so they can get treatment sooner and improve their heart health.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10871889

• Creating a new treatment to remove amyloid deposits in patients with systemic amyloidosis

  This study is testing a new treatment that uses special antibodies to help your immune system remove harmful amyloid deposits from your body if you have systemic amyloidosis, with the hope of improving your health and making future treatments more effective.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-10792590

• Detecting heart issues caused by protein buildup in older adults

  This study is looking for early signs of a heart condition called transthyretin cardiac amyloidosis (ATTR-CA) in older adults, using special imaging to spot changes in the heart before any symptoms show up, so that treatment can start sooner and help manage heart health better.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-10569547

• Creating new models to study brain diseases like Alzheimer's

  This study is creating special mouse models to help scientists learn more about how two important factors in Alzheimer's disease work together, which could lead to better understanding and treatments for people with the condition.

  NIH research University of Florida · Gainesville, United States · NIH-10458822

Related topics

Quick answers

How many Amyloidosis clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 25 countries. The most sites are in United States (15 trials), China (5 trials), France (3 trials), Belgium (3 trials), Germany (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 4, Phase 3: 2, Phase 1/2: 2, Phase 4: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

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