Condition

Colitis clinical trials and research

• 10Clinical trials
• 77NIH research projects
• 40Countries

Newest Colitis clinical trials

All recruiting trials (10)

• Guselkumab in Ulcerative Colitis and Crohn’s Disease in Saudi Arabia: Real-World Use

  This study looks at how long people with moderate-to-severe Crohn’s disease or ulcerative colitis continue taking guselkumab in everyday clinical practice in Saudi Arabia.

  Recruiting Janssen Research & Development, LLC · Jeddah · NCT07541261

• KAN-004 treatment for immune-related diarrhea and colitis

  This trial is testing whether KAN-004 is safe and tolerable for adults who develop moderate-to-severe diarrhea or colitis after treatment with immune checkpoint inhibitors.

  Recruiting Phase 1 Centre hospitalier de l'Université de Montréal (CHUM) · Montreal, Quebec · NCT07196410

• Probiotic 6600 as an add-on treatment for ulcerative colitis, Crohn's disease, and colitis

  This trial will test whether adding Probiotic 6600 to usual care helps adults with ulcerative colitis, Crohn's disease, or nonspecific colitis reach clinical remission over 24 weeks.

  Recruiting Phase 2/3 Changhai Hospital · Shanghai · NCT07047339

• Long-acting antibody treatments alone and in combinations for moderate to severe ulcerative colitis

  This tests long-acting antibody medicines, given after an IV induction and then as under-the-skin maintenance, to see if they help adults with moderate to severe ulcerative colitis.

  Recruiting at 276 sites Phase 2 Spyre Therapeutics, Inc. · Canoga Park, California and 275 other locations · NCT07012395

• Vedolizumab to prevent ICI-related diarrhea or colitis in cancer patients

  This study tests whether vedolizumab can prevent immune checkpoint inhibitor–related diarrhea or colitis in adults with unresectable or metastatic melanoma, lung, or kidney cancer starting immunotherapy.

  Recruiting Phase 2/3 AHS Cancer Control Alberta · Calgary, Alberta and 1 other locations · NCT06337695

• Using fecal microbiota transplantation to treat diarrhea and colitis from cancer immunotherapy

  This study tests if a stool transplant can help people with melanoma or kidney cancer who are having severe diarrhea and colitis from their immunotherapy treatment.

  Recruiting University of Aarhus · Aarhus N · NCT06206707

• Using infliximab to treat colitis caused by immune checkpoint inhibitors

  This study is testing if adding infliximab to standard steroid treatment can help people with severe colitis or diarrhea caused by cancer immunotherapy feel better faster.

  Recruiting Phase 3 Odense University Hospital · Aalborg and 2 other locations · NCT05947669

• A pilot test of Restorative Microbiota Therapy for immune‑related colitis from cancer immunotherapy

  This pilot study tests Restorative Microbiota Therapy to see if it can help people with immune‑related colitis caused by cancer immunotherapy who have not responded to steroids.

  Recruiting at 9 sites Phase 2 University of Minnesota · Brainerd, Minnesota and 8 other locations · NCT05726396

• Using fecal microbiota transplantation to treat diarrhea or colitis in cancer patients

  This study is testing whether a treatment using healthy gut bacteria can help cancer patients with diarrhea or colitis caused by their cancer treatment feel better.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT04038619

• Exploring gut microbiome and fecal transplant effects on GI issues in cancer patients

  This study is testing how the gut bacteria affect stomach issues in cancer patients receiving certain treatments and whether a stool transplant can help relieve those problems.

  Recruiting Phase 1 M.D. Anderson Cancer Center · Houston, Texas · NCT03819296

NIH-funded research (newest 40 of 77)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How our genes and immune system affect C. difficile infections

  This project looks at how a common human gene variant and immune factors influence the severity of C. difficile infections and whether targeting inflammation could help patients.

  NIH research University of Arizona · Tucson, United States · NIH-11585001

• Outpatient pathway for severe ulcerative colitis in the right care setting

  This study tests a safe, outpatient approach using an oral therapy and remote monitoring for people with acute severe ulcerative colitis to avoid hospitalization.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11438442

• Fh15-based therapy to calm inflammation in sepsis and ulcerative colitis

  A research project tests a molecule from a parasitic organism (Fh15) to reduce harmful inflammation in adults with sepsis or ulcerative colitis.

  NIH research University of Puerto Rico Med Sciences · San Juan, United States · NIH-11424600

• IMYX-3 treatment for ulcerative colitis

  A new therapy approach called IMYX-3 aims to help adults with moderate to severe ulcerative colitis who have not responded well to current treatments.

  NIH research Immunyx Pharma USA INC. · New York, United States · NIH-11413607

• Autoantibodies and ulcerative colitis: how avb6 antibodies may drive disease

  This NIH grant aims to understand how antibodies against a gut cell protein (αvβ6) may actively contribute to ulcerative colitis and what that means for future treatments.

  NIH research Benaroya Research Inst at Virginia Mason · Seattle, United States · NIH-11412898

• Selenium supplementation to help moderate-severe ulcerative colitis flare-ups

  This grant tests whether giving selenium can help people with moderate to severe ulcerative colitis reduce flares and improve symptoms.

  NIH research Northwestern University · Chicago, United States · NIH-11412675

• Development of TP-317 for Ulcerative Colitis

  A new therapy approach for ulcerative colitis aims to repair the intestinal lining and restore immune balance in people with UC, addressing a need for patients who don’t fully respond to current treatments.

  NIH research Thetis Pharmaceuticals, LLC · Deep River, United States · NIH-11406737

• How AHR and NLRP6 affect the gut lining in colitis

  This work explores whether a gut microbe–derived compound called Urolithin A can strengthen the intestinal barrier and help people with inflammatory bowel disease like Crohn’s and ulcerative colitis.

  NIH research University of Louisville · Louisville, United States · NIH-11401873

• Sulfite and mitochondrial function in pediatric ulcerative colitis

  A child-focused project will study how sulfites in the diet affect mitochondria and gut lining cells in kids with ulcerative colitis.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11398638

• Tailored American diet to reduce gut inflammation in ulcerative colitis

  A doctor-led study will test whether an American-tailored, lower-fat, higher-fiber diet helps people with ulcerative colitis achieve remission.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11391291

• How gut bacteria and immune signals may drive pre-cancer changes in ulcerative colitis

  This project looks at whether changes in gut bacteria and an enzyme called DUOX2 cause pre-cancerous (dysplasia) changes in people with ulcerative colitis.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11382262

• How sulfites affect colon cell health in children with ulcerative colitis

  This research looks at whether common dietary sulfites damage colon stem cells and their mitochondria in children with ulcerative colitis.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11381300

• Hyperbaric oxygen for severe ulcerative colitis flares in the hospital

  This trial gives hospitalized people with moderate-to-severe ulcerative colitis flares hyperbaric oxygen or a sham treatment to see if it speeds recovery and prevents surgery.

  NIH research Northwestern University · Chicago, United States · NIH-11378296

• Identifying neutrophil help for why biologics stop working in ulcerative colitis

  A research team at Northwestern University is studying why some people with ulcerative colitis stop responding to common biologic medicines and how specific neutrophil cells in the gut might drive this resistance.

  NIH research Northwestern University · Chicago, United States · NIH-11372193

• Characterization of IL-33–responsive mucosal cells linked to colitis-associated cancer

  A small study will look at how a specific immune signal (IL-33) inside the gut might influence cancer risk for people with ulcerative colitis.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11371798

• Oral immunotherapy using engineered bacteria to treat ulcerative colitis

  A new, lab-made cellular medicine using friendly gut bacteria aims to reduce inflammation in adults with ulcerative colitis and Crohn’s disease by strengthening the intestinal barrier.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11371157

• How TL1A affects key gut immune cells in colitis

  Researchers aim to find whether the protein TL1A changes how certain gut immune cells behave in people with inflammatory bowel disease (colitis) to guide safer treatments.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11364915

• WNT2B could help reduce inflammation in colitis

  A study at a children’s hospital will test whether increasing a protein called WNT2B can calm inflammation in the gut for people with colitis.

  NIH research Nemours Children's Hospital, Delaware · Wilmington, United States · NIH-11364683

• Role of epithelial ROS signaling in stress-related gut dysfunction and colitis risk

  This NIH grant looks at how stress changes the gut lining and its microbes, possibly increasing the risk of inflammatory bowel disease in people who are genetically predisposed.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11361588

• Gut bacteria and immune causes of colitis from CTLA-4 cancer therapy

  This project looks at how gut bacteria and immune responses cause bowel inflammation in people getting CTLA-4 cancer antibodies so we can find ways to prevent or treat it.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11331237

• Gut bacteria that worsen colitis

  This research looks at whether common antibiotics and processed foods change gut bacteria so a sugar alcohol called sorbitol builds up and makes colitis worse, and whether probiotics or enzyme pills can help people with inflammatory bowel disease.

  NIH research University of California at Davis · Davis, United States · NIH-11319307

• Gut-targeted IL-10 therapy to prevent gut inflammation from cancer immunotherapy

  A tiny, engineered yeast delivers a calming immune protein directly in the gut to prevent colitis in people treated with immune checkpoint inhibitors.

  NIH research Fzata, INC. · Halethorpe, United States · NIH-11314083

• Folic acid and colon cancer risk in ulcerative colitis

  This research looks at whether taking folic acid changes colon cancer risk for people with ulcerative colitis, especially when certain cell changes are present.

  NIH research Research Inst of Fox Chase Can Ctr · Philadelphia, United States · NIH-11311911

• Multimodal imaging to predict ulcerative colitis relapse

  A new imaging platform will be built to map tissue and immune signals in the gut to better predict when ulcerative colitis might flare again.

  NIH research University of Illinois at Urbana-Champaign · Champaign, United States · NIH-11302835

• Crohn's-like inflammation in the ileal pouch after colon removal for ulcerative colitis

  This project looks for genetic, tissue, microbiome, and metabolite patterns linked to Crohn’s-like inflammation in people with ulcerative colitis who had their colon removed and an ileal pouch created.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11287861

• How immune cells and Th17 inflammation drive colitis-related colon cancer

  This project looks at how certain immune cells and ongoing gut inflammation help cause colon cancer in people with long-term colitis.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11263745

• How two proteins (HDAC4 and HDAC7) may drive harmful immune cells and colitis

  This project aims to find out whether the proteins HDAC4 and HDAC7 make Th17 immune cells more damaging and contribute to colitis and other autoimmune diseases.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11258852

• How the CREM gene helps protect the gut in amebic colitis and inflammatory bowel disease

  This project looks at whether the CREM gene helps protect people from gut inflammation caused by amebiasis and inflammatory bowel disease.

  NIH research University of Virginia · Charlottesville, United States · NIH-11242003

• Gut bacteria and colorectal cancer risk in people with ulcerative colitis

  Researchers are looking at whether certain gut bacteria help protect against or promote colorectal cancer in people who have ulcerative colitis.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11241980

• T cells that target a gut protein (integrin αvβ6) in ulcerative colitis

  This project looks for immune T cells that help make antibodies against a gut protein called integrin αvβ6 in people with ulcerative colitis.

  NIH research Benaroya Research Inst at Virginia Mason · Seattle, United States · NIH-11240348

• Understanding how inflammation contributes to colorectal cancer development

  This study is looking at how long-lasting inflammation in the intestines might lead to colorectal cancer, and it's for people who want to understand more about the disease and how to improve treatments by exploring the immune system's role in tumor growth.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11231961

• TREM1-targeted immune therapy to lower gut inflammation in older adults with ulcerative colitis

  This project is developing a treatment that blocks the TREM1 inflammation pathway to reduce colon inflammation in older adults with ulcerative colitis.

  NIH research Bioprovar Corporation · Houston, United States · NIH-11195660

• An Oral Treatment for Ulcerative Colitis

  This project is creating a new oral medicine that uses natural gut bacteria to calm inflammation for people with inflammatory bowel disease, like ulcerative colitis.

  NIH research Rise Therapeutics, LLC · Rockville, UNITED STATES · NIH-11193481

• American-style low-fat, high-fiber diet to reduce gut inflammation in ulcerative colitis

  A low-fat, high-fiber American-style diet with a balanced n-6:n-3 fat ratio to help adults with mild to moderate ulcerative colitis reach remission.

  NIH research University of Miami School of Medicine · Coral Gables, United States · NIH-11180220

• Understanding how our bodies respond to C. difficile infection

  This research explores why some people get sicker from C. difficile infections than others, focusing on individual genetic and immune differences.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11169012

• Factors linked to microscopic colitis

  This research looks at links between medications, hormones, body weight, and gut bacteria in people with microscopic colitis.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11168863

• How the environmental sensor AhR affects colitis

  Seeing whether plant-derived compounds that activate the AhR sensor can lower gut inflammation and boost natural antimicrobial defenses for people with colitis.

  NIH research University of South Carolina at Columbia · Columbia, United States · NIH-11167451

• Exploring how creatine affects the development of protective cells in the intestines during colitis.

  This study is looking at how creatine, a substance your body makes, helps create special cells that keep your intestines healthy, and it's aimed at people with inflammatory bowel disease (IBD) like ulcerative colitis and Crohn's disease, to find new ways to improve gut health.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11166343

• VV8220 — a gut-targeted CRAC channel medicine for ulcerative colitis

  This project develops an oral, gut-restricted drug called VV8220 to reduce gut inflammation in people with ulcerative colitis.

  NIH research Vivreon Biosciences, LLC · San Diego, UNITED STATES · NIH-11159849

• Understanding how deep inflammation in ulcerative colitis affects patient outcomes

  This study is looking at how changes in the deeper layers of the bowel affect the health and quality of life of people with ulcerative colitis, using ultrasound to find out what might help improve their symptoms and overall care.

  NIH research University of Chicago · Chicago, United States · NIH-11138143

Related topics

Quick answers

How many Colitis clinical trials are recruiting right now?

10, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 40 countries. The most sites are in Canada (3 trials), United States (3 trials), Denmark (2 trials), China (1 trial), United Kingdom (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 3, Phase 2/3: 2, Phase 2: 2, Phase 3: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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