Identifying Prognostic Factors in Inflammatory Bowel Disease
Official title: Predictors of Response After Induction Therapy With TNF-alpha Inhibitor in Inflammatory Bowel Disease, Comparison to Normal
Run by Seoul National University Bundang Hospital · NCT05653011 · Data updated 2026-11-12
This study is trying to find out which signs and markers can help predict how inflammatory bowel disease will progress in people with Crohn's disease and ulcerative colitis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Seoul National University Bundang Hospital Academic / other |
| Locations | 1 site (Seongnam-si, Gyeonggi-do) |
| Status | Recruiting |
| Started | March 11, 2013 |
| Main results expected | October 31, 2026 |
| Study ends | December 31, 2026 |
| Registry record updated | April 24, 2026 |
| Trial ID | NCT05653011 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include IBD patients who are either naive to TNF-α inhibitors or currently receiving TNF-α inhibitor treatment, as well as non-IBD controls.
✕Probably not a fit
Patients under 18 years old or those who have received antibiotics or probiotics in the last three months may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study focuses on understanding the clinical characteristics and potential prognostic factors in patients with inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis. The research involves collecting endoscopic biopsy and blood samples from IBD patients and non-IBD controls to assess the expression levels of various markers associated with disease activity and severity. The goal is to evaluate the correlation between these markers and the prognosis of IBD patients, addressing the challenges of predicting disease outcomes.
Why it matters
Potential benefit: If successful, this study could lead to improved prognostic tools for managing inflammatory bowel disease, helping clinicians tailor treatment strategies for better patient outcomes.
How similar studies have gone: While the study's approach is focused on prognostic factors, similar studies have shown promise in identifying markers that correlate with disease outcomes in IBD.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * control group: Patients who do not have colitis, cancer, and advanced polyp (the number of polyps ≥ 3, the size of polyps ≥ 1cm, high-grade adenoma, villous adenoma) * TNF-α inhibitor-naive IBD group: IBD patients who do not have a history of TNF-α inhibitor treatment * TNF-α inhibitor-treated IBD group: IBD patients who are treated with TNF-α inhibitor Exclusion Criteria: * Age under 18 years * Patients who were treated with antibiotics or probiotics within the last 3 months
Where it's running
-
Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, South Korea Recruiting
Study contacts
- Study coordinator: Yu kyung Jun, M.D., Ph.D
- Email: juk0220@nate.com
- Phone: + 82-31-787-7845
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
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Observational study comparing inflammatory markers in IBD and non-IBD participants
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Research on gut inflammation in pediatric patients with inflammatory bowel diseases
This study is trying to learn more about gut inflammation in kids with inflammatory bowel diseases by collecting health information and samples from them and comparing it to kids who have different gut issues but no inflammation.
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Switching to subcutaneous infliximab for IBD treatment
This study is testing if switching people with inflammatory bowel disease from an intravenous form of infliximab to a subcutaneous version, given weekly or bi-weekly, can lead to better health results.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.