Examining the link between polyamine levels and inflammatory bowel disease progression

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates how polyamine levels and their associated enzymatic activities correlate with the progression of inflammatory bowel diseases (IBD), including Ulcerative Colitis and Crohn's Disease. It aims to establish a predictive model for IBD progression by measuring polyamine and metabolite levels, as well as assessing the efficacy of biologics through polyamine detection. The study will involve 91 patients diagnosed with IBD and 46 healthy controls, utilizing high-performance liquid chromatography and mass spectrometry for analysis. Additionally, it will explore gut microbiota alterations related to polyamine metabolism to provide insights for probiotic guidance.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Age between 18 and 65 years;
2. Diagnosed with inflammatory (IBD) according to the Chinese Guidelines for the Diagnosis and Treatment of Ulcerative Colitis (2023, Xi'an) and the Chinese Guidelines for the Diagnosis and Treatment of Crohn's Disease (2023, Guangzhou);
3. Complete medical records available and written informed consent obtained from the participant.

Exclusion Criteria:

1. Presence of other metabolic disorders;
2. History of malignant tumors, severe organ dysfunction, or other severe systemic diseases affecting major organs, or hematological disorders;
3. Diagnosis of influenza, bacterial dysentery, or other infectious diseases within the past 2 weeks;
4. Presence of other diseases that may interfere with polyamine metabolism;
5. Use of antibiotics or probiotics within 8 weeks prior to the start of the study.

Where it's running

• Xijing Hospital
  Xi'an, Shaanxi, China Recruiting

Study contacts

• Principal investigator: Kaichun Wu — Xijing Hospital
• Study coordinator: Hao Zhang
• Email: 514602793@qq.com
• Phone: +8613677056116

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.