ulcerative colitis Clinical Trials and Research
Also known as: uc, colitis ulcerosa, chronic colitis, inflammatory bowel disease, ulcerative proctitis · ICD-10: K51
Ulcerative colitis is a chronic inflammatory bowel disease affecting the large intestine, causing inflammation and ulcers. Clinical trial research focuses on developing new therapies to manage symptoms, induce remission, and prevent complications. Find a Trial helps patients search for active studies exploring these advancements.
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Common questions about ulcerative colitis clinical trials
What makes someone eligible for an ulcerative colitis clinical trial?
Eligibility criteria vary greatly by study, often including age, disease severity, previous treatments, and overall health. Researchers use these criteria to ensure patient safety and collect relevant data. Information is available on ClinicalTrials.gov.
What are the different phases of clinical trials for ulcerative colitis?
Clinical trials progress through phases, from early safety testing (Phase 1) to evaluating effectiveness and side effects (Phase 2 and 3) in larger groups. Phase 4 studies monitor approved treatments long-term. This structured approach helps ensure new treatments are safe and effective, as tracked on ClinicalTrials.gov.
Do clinical trials for ulcerative colitis cost money to participate in?
Generally, study-related medical care, tests, and investigational drugs are provided at no cost to participants. However, some trials may not cover travel or other personal expenses. Details are outlined in the informed consent process for each study.
What are current research directions for ulcerative colitis treatments?
Current research explores novel anti-inflammatory drugs, targeted biologics, small molecule inhibitors, and therapies that modulate the gut microbiome. Scientists are also investigating personalized medicine approaches to better match treatments to individual patients. Data from NIH RePORTER and ClinicalTrials.gov show these active areas.
What types of interventions are commonly studied in ulcerative colitis trials?
Common interventions include new oral medications, injectable biologics that target specific immune pathways, and sometimes dietary or lifestyle interventions. Surgical approaches are also studied for severe cases. These interventions aim to reduce inflammation and promote mucosal healing, as seen on ClinicalTrials.gov.
Are there specific biomarkers used in ulcerative colitis clinical trials?
Yes, researchers often use biomarkers like fecal calprotectin, C-reactive protein (CRP), and endoscopic scores to assess disease activity and treatment response. Genetic markers and microbiome profiles are also being explored to predict disease course and treatment efficacy. These are key to understanding disease progression, according to NIH RePORTER.
What are common reasons someone might be excluded from an ulcerative colitis trial?
Common exclusion criteria can include active infections, certain co-existing medical conditions, pregnancy, or recent use of specific medications that might interfere with the study drug. These criteria ensure patient safety and the integrity of trial results, as detailed on ClinicalTrials.gov.
Do clinical trials investigate the long-term effects of ulcerative colitis treatments?
Yes, many clinical trials, especially Phase 3 and 4 studies, include long-term follow-up to assess the sustained efficacy and safety of new treatments. Researchers monitor for side effects and disease recurrence over extended periods. This long-term data is crucial for patient care, as seen on ClinicalTrials.gov.
How to find a ulcerative colitis trial that fits you
- Describe your ulcerative colitis situation in detail — stage if applicable, prior treatments, age, and other relevant conditions.
- Use the location filter (worldwide, US, US & Canada, Europe) to narrow to trials near you.
- Review each trial's eligibility criteria carefully. Save 2–5 candidates with their NCT numbers.
- Discuss with your treating clinician before contacting the research site.
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