Condition

Clostridioides Difficile Infection clinical trials and research

• 16Clinical trials
• 23NIH research projects
• 30Countries

Newest Clostridioides Difficile Infection clinical trials

All recruiting trials (16)

• Diet and counseling to see how meals affect gut health after CDI

  We’re testing whether different meal plans and health counseling can influence the gut microbiome and reduce chances of CDI coming back in adults who are being treated for CDI.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT07613645

• Lyophilized fecal microbiota transplant for adults with active ulcerative colitis

  This trial will test whether a dried (lyophilized) fecal microbiota transplant helps adults with active ulcerative colitis when added to their current treatment or started alongside a new advanced medication.

  Recruiting Phase 1 University of Alberta · Calgary, Alberta and 1 other locations · NCT07401680

• How antibiotics versus fecal transplants affect recovery from C. difficile infection

  This project will see how antibiotics and fecal microbiota transplant (FMT) affect adults with C. difficile infection by tracking recovery and biological changes over time.

  Recruiting Umeå University · Umeå · NCT07374094

• Preventing recurrent C. difficile infection with the AZD5148 antibody

  This will try a single dose of the antibody AZD5148 versus placebo to see if it prevents repeat C. difficile infections in adults being treated for a current infection.

  Recruiting at 95 sites Phase 2 AstraZeneca · Phoenix, Arizona and 116 other locations · NCT07285213

• Preventing C. difficile recurrence with short-course oral vancomycin during later antibiotics

  This trial tests whether taking short-course oral vancomycin while you need systemic antibiotics can prevent a recurrence of C. difficile in adults recently treated for CDI.

  Recruiting Phase 2/3 McGill University Health Centre/Research Institute of the McGill University Health Centre · Montreal, Quebec · NCT06979609

• UDCA added to standard therapy to prevent C. diff recurrence

  This study tests whether taking ursodeoxycholic acid alongside standard antibiotics can reduce recurrence of C. difficile colitis in adults at risk.

  Recruiting Early Phase 1 Medical College of Wisconsin · Milwaukee, Wisconsin · NCT06884748

• Using Lactobacillus Plantarum to Prevent Clostridium Difficile Infections in Hospitalized Patients

  This study is testing if a specific probiotic can help prevent Clostridium difficile infections in hospitalized patients who are taking antibiotics and immunosuppressive treatments.

  Recruiting Medical University of Silesia · Poland, Silesian Voivodeship · NCT06859437

• Exploring Clostridioides Difficile Infections in Infants

  This study looks at Clostridioides difficile infections in babies under 2 years old to see how it affects them and what might put them at risk.

  Recruiting Westlake University · Hangzhou, Zhejiang · NCT06788769

• New treatment to prevent Clostridioides difficile infection recurrence in high-risk patients

  This study is testing a new treatment called EXL01 to see if it can help high-risk patients who keep getting Clostridioides difficile infections stay infection-free.

  Recruiting at 9 sites Phase 1/2 Hospices Civils de Lyon · Annecy and 9 other locations · NCT06306014

• VE303 for preventing recurrent Clostridioides difficile infections

  This study is testing a new treatment called VE303 to see if it can help prevent Clostridioides difficile infections from coming back in people who are at high risk.

  Recruiting at 130 sites Phase 3 Vedanta Biosciences, Inc. · Huntsville, Alabama and 214 other locations · NCT06237452

• Washing and transplanting gut bacteria to treat Clostridioides Difficile Infection

  This study is testing if washing and transplanting gut bacteria can help people with Clostridioides Difficile Infection feel better and recover.

  Recruiting The Second Hospital of Nanjing Medical University · Nanjing, Jiangsu · NCT06106698

• Using fecal microbiota transplantation to treat Clostridioides difficile infections

  This study is testing if a new treatment using fecal microbiota transplantation can help people with their first Clostridioides difficile infection or its first recurrence feel better and prevent future infections after standard antibiotic treatment.

  Recruiting at 8 sites Phase 3 Centre Hospitalier Universitaire Vaudois · Basel, Basel and 7 other locations · NCT05266807

• Fecal microbiota transfer for treating initial Clostridioides difficile infections

  This study is testing whether a fecal microbiota transfer treatment can help people who are having their first Clostridioides difficile infection by restoring their gut health and preventing the infection from coming back.

  Recruiting Turku University Hospital · Turku · NCT05257538

• Using alanyl-glutamine to treat C. difficile infections

  This study is testing if taking alanyl-glutamine can help people with C. difficile infections recover better and prevent the infection from coming back.

  Recruiting at 2 sites Phase 2 University of Virginia · Charlottesville, Virginia and 1 other locations · NCT04305769

• Using fecal microbiota transplantation to treat severe intestinal infections

  This study is testing whether a new way of using fecal transplants can help people with severe intestinal infections, like C. difficile, feel better and recover.

  Recruiting The Second Hospital of Nanjing Medical University · Nanjing, Jiangsu · NCT03895593

• Fecal Transplant for Clostridioides difficile Infection

  This project tests fecal microbiota transplantation for adults with Clostridioides difficile infection to see if it helps treat the illness.

  Recruiting University of Aarhus · Aarhus N · NCT03712722

NIH-funded research (23)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how the immune system fights C. difficile to prevent recurrence

  A new NIH grant is studying how the body’s own immune response to C. difficile infection might be boosted to prevent future outbreaks.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11498687

• Impact of gut bile acids on C. difficile infection in inflammatory bowel disease

  This grant tests whether changes in gut microbes and their bile acids influence how likely people with inflammatory bowel disease are to get and how severe a C. difficile infection could be.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11398269

• Role of gut bacteria in shaping C. difficile infection

  Aims to map how the gut microbiome and its metabolic environment influence Clostridioides difficile infection in people and how we might prevent or treat it.

  NIH research Children's Hosp of Philadelphia · Philadelphia, United States · NIH-11381050

• Detailed genetic look at C. difficile and the gut microbiome in infection and relapse

  Researchers will sequence C. difficile and gut bacteria from thousands of patient stool samples to find genetic and microbial patterns linked to severe or recurring infections.

  NIH research Washington University · Saint Louis, United States · NIH-11311860

• Multivalent vaccine to prevent C. difficile infection and recurrence

  This project is developing a vaccine that teaches the immune system to neutralize C. difficile toxins and block the bacteria from coming back for people at risk of infection.

  NIH research University of South Florida · Tampa, United States · NIH-11258986

• Gut-targeted antibiotics for C. difficile infection

  Developing gut-targeted antibiotics to kill C. difficile while keeping healthy gut bacteria for people with recurrent C. difficile infections.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11240315

• Technology-Driven Root-Cause Analysis and Clinical Enhancement for C. difficile Infections

  A new digital platform uses hospital data to streamline how hospitals analyze and prevent hospital-acquired C. diff infections.

  NIH research Datanova Scientific LLC · Surfside Beach, United States · NIH-11186538

• How aging affects gut bacteria and Clostridioides difficile infections

  This study is looking at how the bacteria in our gut change as we get older and how these changes might make older adults more likely to get Clostridioides difficile infections, with the goal of finding ways to help keep them healthier.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11109431

• Investigating how gut bacteria interact with Clostridioides difficile infections

  This study is looking at how a harmful germ called Clostridioides difficile interacts with the good bacteria in the gut of people who have infections, to help find out why some people get sicker than others and to improve treatments for everyone.

  NIH research Washington University · Saint Louis, United States · NIH-11093474

• Understanding how nutrition affects infections caused by C. difficile

  This study is looking at how the nutrients in our bodies and the balance between good and bad bacteria in our gut affect infections from Clostridioides difficile, especially in people who have recently taken antibiotics, to find better ways to prevent and treat these infections.

  NIH research Vanderbilt University Medical Center · Nashville, United States · NIH-11092009

• Using diet to prevent Clostridioides difficile infections

  This study is looking at how eating more fiber and less fat might help people, especially those with cancer, avoid infections from C. diff by changing the bacteria in their gut and how their bodies respond to antibiotics.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11075786

• Exploring how interferon lambda helps protect against severe Clostridioides difficile infections

  This study is looking at how a substance called interferon lambda might help protect people from serious infections caused by Clostridioides difficile, which often leads to gut problems in hospitals, and it hopes to find new ways to help heal the gut and improve treatment options for patients.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11060175

• Creating new antibiotics that spare healthy gut bacteria for treating Clostridioides difficile infections

  This study is looking for new ways to treat Clostridioides difficile infections by targeting a specific enzyme that helps the bacteria survive, aiming to create safe treatments that won't harm the good bacteria in your gut.

  NIH research University of Tennessee Health Sci Ctr · Memphis, United States · NIH-11047461

• How pet ownership affects gut health and Clostridioides difficile infections

  This study is looking at how having pets might help your gut health bounce back after taking antibiotics, especially when it comes to fighting off infections like Clostridioides difficile, and we’d love for you to join us by sharing some samples and information to help us learn more!

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11044056

• Understanding how the immune system responds to Clostridioides difficile infection

  This study is looking at why some people who recover from a Clostridioides difficile infection don’t seem to build lasting immunity, and it aims to find ways to help protect those at higher risk from getting sick again.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11037959

• Comparing new treatments for Clostridioides difficile infection

  This study is testing a new daily pill that aims to help people with Clostridioides difficile infection without using traditional antibiotics, so it can keep your gut healthy while reducing the chances of the infection coming back.

  NIH research Biotherapeutics, INC. · Blacksburg, United States · NIH-11007011

• Exploring immune responses to fight Clostridioides difficile infections

  This study is looking at how certain immune cells in your body can be activated to help fight off Clostridioides difficile infections, with the goal of finding new ways to boost your immune response and improve treatments for this infection.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-10897165

• Identifying immune responses to Clostridioides difficile infection

  This study is looking at how your immune system fights off Clostridioides difficile infection by examining special immune cells in your blood, which could help create better treatments and prevention methods just for you.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-10886133

• How gut bacteria and bile acids affect Clostridioides difficile infections in patients with inflammatory bowel disease.

  This study is looking at how the bacteria in your gut and certain substances called bile acids might affect the risk of Clostridioides difficile infections in people with inflammatory bowel disease, and it will also test if adding specific bile acids can help make these infections less severe.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-10873907

• Understanding immune responses to Clostridioides difficile infections

  This study is looking at how the immune system reacts to Clostridioides difficile infections to help doctors understand which patients might be at greater risk for serious problems, so they can provide better care and treatment.

  NIH research University of Virginia · Charlottesville, United States · NIH-10865000

• Comparing two treatments for recurrent Clostridioides difficile infection

  This study is looking at how well a special live treatment works compared to a stool transplant for people who keep getting C. difficile infections, to see if it can help them feel better and improve their gut health in a safer way.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-10845658

• A blood test to check immunity against Clostridioides difficile infection

  This study is working on a new blood test to see if people who have had a Clostridioides difficile infection have enough antibodies to stop it from coming back, making it easier to manage the infection and reduce the chances of it returning.

  NIH research Fzata, INC. · Halethorpe, United States · NIH-10682402

• Investigating how a high-fat/high-protein diet affects Clostridioides difficile infections

  This study is looking at how a high-fat and high-protein diet affects people with Clostridioides difficile infections, which can happen after taking antibiotics, to see if changing what you eat could help improve your gut health and fight the infection.

  NIH research University of Nevada Las Vegas · Las Vegas, United States · NIH-10515273

Related topics

Quick answers

How many Clostridioides Difficile Infection clinical trials are recruiting right now?

16, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 30 countries. The most sites are in United States (5 trials), Canada (4 trials), China (3 trials), France (3 trials), Denmark (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 3: 2, Phase 2: 2, Phase 1/2: 1, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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