Mesenteric Fat Freeze to Improve Insulin Control
Official title: Mesenteric Fat Cryolipolysis to Reverse Insulin Resistance
Funded at B2m Medical, INC. · NIH-11313888 · Data updated 2026-11-12
A new treatment using targeted fat-freezing, aimed at adults with type 2 diabetes to help improve blood sugar control.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | B2m Medical, INC. NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project start | September 19, 2022 |
| Project end | July 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $746,360 |
| NIH project number | 2R44DK133015-02 |
| Project ID | NIH-11313888 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with type 2 diabetes who have visceral mesenteric fat and meet safety criteria for the procedure.
✕Less likely to help
Individuals without type 2 diabetes or without mesenteric fat who don’t meet safety criteria may not benefit.
What this research studies
This project explores whether removing a specific type of belly fat called mesenteric fat through a non-surgical freezing method can help people with type 2 diabetes better manage their blood sugar. It builds on evidence that visceral fat contributes to insulin resistance and that reducing this fat may improve glycemic outcomes. The study plans to test a safe, controlled fat-freezing approach and monitor effects on insulin sensitivity, glucose control, and quality of life. Participation would involve screening, the treatment session, and follow-up visits to track safety and metabolic results. The goal is to offer a less invasive option to improve diabetes management and reduce complications.
Why it matters
Potential benefit: If successful, patients could achieve better blood sugar control and potentially reduce diabetes-related complications.
How similar studies have gone: Prior studies in animals and some humans suggest fat reduction can improve insulin sensitivity, but this specific mesenteric fat freezing approach is novel.
Where this research is happening
-
B2m Medical, INC.
Irvine, United States Active
Researchers
- Principal investigator: Mazor, Rafi — B2m Medical, INC.
- Study coordinator: Mazor, Rafi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.