How insulin resistance affects exercise capacity in diabetes
Official title: Role of Microvascular insulin resistance and cardiorespiratory fitness in diabetes
Funded at University of Colorado Denver · NIH-11085267 · Data updated 2026-11-12
This study is looking at how insulin resistance affects exercise ability in people with type 2 diabetes, and it hopes to find out if exercise training can help improve insulin function and blood flow, making it easier for you to be active and stay healthy.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | April 1, 2021 |
| Project end | March 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $711,928 |
| NIH project number | 5R01DK124344-04 |
| Project ID | NIH-11085267 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults aged 21 and older who have been diagnosed with type 2 diabetes.
✕Less likely to help
Patients who do not have type 2 diabetes or those under 21 years old may not benefit from this research.
What this research studies
This research investigates the connection between insulin resistance and exercise capacity in individuals with type 2 diabetes. It aims to understand how impaired insulin regulation affects blood flow in the heart and muscles, which may limit physical performance. The study will involve assessing how exercise training can improve insulin function and enhance blood flow, potentially leading to better exercise outcomes for patients. By exploring these relationships, the research seeks to provide insights into improving cardiovascular health in those with diabetes.
Why it matters
Potential benefit: If successful, this research could lead to improved exercise capacity and cardiovascular health for patients with type 2 diabetes.
How similar studies have gone: Previous research has shown promising results in improving exercise capacity through interventions targeting insulin resistance, suggesting that this approach may be effective.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Reusch, Jane E — University of Colorado Denver
- Study coordinator: Reusch, Jane E
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.