Condition

Insulin Sensitivity clinical trials and research

• 19Clinical trials
• 30NIH research projects
• 5Countries

Newest Insulin Sensitivity clinical trials

All recruiting trials (19)

• Improve Teen Sleep to Support Healthy Blood Sugar and Metabolism

  This study tests whether extending and timing teens’ sleep, with melatonin and morning light, can improve insulin sensitivity and energy use in overweight adolescents.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT07618117

• Weekly physiologic insulin sessions to improve insulin sensitivity and memory in Alzheimer’s

  This trial will test whether weekly short (up to two-hour) physiologic insulin sessions can improve how the body uses glucose and help thinking and memory in adults with Alzheimer’s disease.

  Recruiting Pennington Biomedical Research Center · Baton Rouge, Louisiana · NCT07265323

• Colchicine to improve insulin sensitivity in people with type 1 diabetes and low-grade inflammation

  This trial will test whether adding colchicine to usual care can improve insulin sensitivity in adults with type 1 diabetes who have chronic low-grade inflammation.

  Recruiting Phase 2 University Hospital, Gentofte, Copenhagen · Gentofte Municipality · NCT07247734

• Understanding how different meals affect metabolism

  This study tests how different types of meals affect metabolism in young adults to see how their bodies respond to various nutrients.

  Recruiting Instituto Nacional de Medicina Genomica · Mexico City · NCT06878781

• Investigating how exercise affects muscle insulin sensitivity

  This study tests how a single session of one-legged exercise affects how well young healthy men’s muscles respond to insulin.

  Recruiting University of Copenhagen · Copenhagen · NCT06776094

• Effects of Lipids on Health in Night Shift Workers

  This study is testing how certain fats in the body affect heart health and blood sugar in people who work night shifts, while also trying a new eating schedule to see if it helps.

  Recruiting Colorado State University · Fort Collins, Colorado · NCT06550115

• Investigating the impact of a GLP-1 medication on brain insulin response

  This study is testing if a medication called semaglutide can change how the brain responds to insulin in people of different weights to see if it helps with thinking and eating habits.

  Recruiting University Hospital Tuebingen · Tübingen · NCT06487832

• Evaluating the best time for resistance exercise to improve insulin sensitivity and sleep

  This study is testing whether doing resistance exercises in the morning or evening helps people aged 50-74 with overweight or obesity improve their insulin sensitivity and sleep quality.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06366399

• Increasing sleep duration to improve health in people with obesity

  This study is testing if getting an extra 2 hours of sleep each night can help people with obesity improve their health and insulin sensitivity.

  Recruiting University of Utah · Salt Lake City, Utah · NCT06180837

• Endoscopic sleeve gastroplasty for people with obesity and MASH

  This study will test whether endoscopic sleeve gastroplasty plus lifestyle changes helps adults with obesity and MASH lose weight and improve liver health compared with lifestyle changes alone.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT06138821

• Impact of weight loss on fat tissue signaling in muscles

  This study is testing how losing weight affects fat tissue in muscles and whether it helps people with obesity improve their insulin sensitivity.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT06129110

• Effects of ultrasound treatment on insulin sensitivity in diabetes

  This study is testing whether ultrasound treatment can help improve insulin sensitivity in people with Type 2 diabetes.

  Recruiting Yale University · New Haven, Connecticut · NCT06042517

• Identifying predictors of weight loss and metabolic health after bariatric surgery

  This study is trying to find out what factors can help predict how well people with insulin resistance will lose weight and improve their health after having bariatric surgery.

  Recruiting Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) · Gouda, South Holland and 2 other locations · NCT05987631

• Improving cardiometabolic health through circadian interventions

  This study is testing whether changing sleep habits and reducing nighttime light and eating can help people with overweight and obesity who don’t get enough sleep improve their health over eight weeks.

  Recruiting University of Utah · Salt Lake City, Utah · NCT05943626

• Investigating the links between obesity, insulin resistance, and long COVID

  This study is trying to see if obesity and insulin resistance make long-lasting COVID-19 symptoms worse, by looking at fat tissue and its role in inflammation and the virus.

  Recruiting Stanford University · Palo Alto, California and 1 other locations · NCT05833217

• Effects of weight loss with and without exercise on metabolic health

  This study is testing whether losing weight with exercise helps improve metabolic health more than just losing weight through dieting alone for people with obesity.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT05806801

• Investigating how exercise affects insulin sensitivity through mTOR

  This study is testing if a medication that blocks a specific pathway in the body can change how exercise helps young healthy men improve their insulin sensitivity.

  Recruiting University of Copenhagen · Copenhagen · NCT05233722

• Effects of Metformin and Automated Insulin Delivery on Youth with Type 1 Diabetes

  This study is testing if adding metformin and an automated insulin delivery system can help young people with type 1 diabetes improve their kidney and heart health.

  Recruiting Phase 1 Seattle Children's Hospital · Aurora, Colorado and 1 other locations · NCT05065372

• Effects of Estradiol on Cardiometabolic Health in Transgender Youth

  This study tests how estradiol affects insulin sensitivity and blood vessel health in transgender girls aged 13-16 compared to girls who are not transgender.

  Recruiting University of Colorado, Denver · Aurora, Colorado · NCT04596592

NIH-funded research (30)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How clock-watching lifestyle affects fats, blood vessels, and insulin in night-shift workers

  This study looks at how being awake and active at night changes lipids in the blood and muscle and what that means for blood vessel function and insulin in adults who work night shifts.

  NIH research Colorado State University · Fort Collins, United States · NIH-11518622

• How bile acids affect insulin and metabolism in humans

  A study using humanized mouse models and human cell systems will explore how a specific group of bile acids (12HBAs) influence insulin signaling and metabolic health in adults.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11391045

• Placental miRNAs and insulin sensitivity in pregnancy

  This grant explores whether tiny molecules from the placenta help control how the mother’s body handles insulin during pregnancy, with potential implications for gestational diabetes.

  NIH research Tufts Medical Center · Boston, United States · NIH-11377301

• Understanding how fat tissue changes affect insulin health

  This grant supports a clinician-scientist to explore how fat tissue in adults with obesity influences insulin sensitivity using human data and advanced analyses.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11374963

• Regulation of a new adipokine that improves insulin sensitivity

  A scientist-led study will explore how a newly found adipokine called NRN1 helps fat tissue control insulin and glucose in adults with obesity and type 2 diabetes.

  NIH research University of California Berkeley · Berkeley, United States · NIH-11358325

• Understanding how lipids affect blood vessels and insulin in night-shift workers

  A study will look at how specific fats circulating in the blood and in tissues relate to blood vessel function and insulin sensitivity in adults who work night shifts.

  NIH research Colorado State University · Fort Collins, United States · NIH-11261650

• Investigating the effects of metformin and automated insulin delivery on kidney and heart health in youth with Type 1 Diabetes

  This study is looking at whether taking metformin along with an automated insulin delivery system can help improve kidney and heart health in young people aged 12-21 with Type 1 Diabetes.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11210200

• How bile acids affect insulin and blood sugar

  Researchers are seeing whether certain bile acids called 12HBAs change how adults' bodies respond to insulin and control blood sugar.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11180238

• Effects of tirzepatide and bimagrumab on body fat, insulin sensitivity, and bone health in adults with obesity

  A study in adults with obesity will look at how two drugs, tirzepatide and bimagrumab, affect fat loss, insulin sensitivity, and bone health.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11179342

• How the placenta affects insulin during pregnancy

  This research explores how tiny molecules from the placenta might control how a mother's body uses insulin during pregnancy.

  NIH research Tufts Medical Center · Boston, United States · NIH-11139571

• A diet with reduced carbohydrates to improve liver health in adolescents with fatty liver disease

  This study is looking at how a diet with fewer carbohydrates can help teenagers with non-alcoholic fatty liver disease improve their liver health and insulin sensitivity, making it easier for them to avoid more serious health issues later on.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11109565

• Using medication to help adolescents with obesity and type 2 diabetes lose weight and improve health.

  This study is looking at how well a medication called liraglutide can help teenagers with obesity and type 2 diabetes lose weight and improve their blood sugar control, with the hope of keeping them healthier in the long run.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11099717

• Understanding how a cell protein affects insulin sensitivity

  This work explores how a specific protein on our cells, called integrin, influences how our bodies use insulin, which is important for people with or at risk for diabetes and heart disease.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11091633

• How liver cell miRNAs affect insulin sensitivity in obesity

  This study is looking at how tiny molecules from liver cells affect how well our bodies respond to insulin, especially in people with obesity and Type 2 diabetes, to find new ways to help improve insulin sensitivity and manage diabetes better.

  NIH research University of California, San Diego · La Jolla, United States · NIH-11084553

• How insulin sensitivity affects metformin's ability to reduce age-related inflammation

  This study is looking at how well metformin, a common diabetes medication, can help healthy people delay inflammation as they age, especially for those who are more sensitive to insulin, so we can find out who might benefit from it before any health issues arise.

  NIH research University of Kentucky · Lexington, United States · NIH-11078849

• Understanding how resistance exercise improves insulin sensitivity in diabetes

  This study is looking at how strength training can help people with type 2 diabetes build muscle and improve how their bodies use insulin, so if you join, you'll get to work out while we learn more about how these exercises can benefit your health!

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11030575

• How night shift work affects blood fats and insulin sensitivity

  This study is looking at how working night shifts might mess with your body's natural clock and affect your heart health and blood sugar, especially for people who do this kind of work, to find ways to help them stay healthier.

  NIH research Colorado State University · Fort Collins, United States · NIH-11026417

• Improving insulin sensitivity in people living with HIV through nutrition in Oklahoma

  The NOURISH OK project is looking at how what you eat can impact insulin sensitivity for people living with HIV, especially those from low-income backgrounds, and it aims to find ways to improve health by understanding the connection between food access and health challenges.

  NIH research University of Oklahoma Hlth Sciences Ctr · Oklahoma City, United States · NIH-10906104

• Investigating the effects of bimagrumab on body composition and insulin sensitivity in adults with obesity

  This study is looking at how a new drug called bimagrumab can help adults with obesity lose fat while keeping their muscles and bones healthy, and it will also include some lifestyle changes to help with weight loss.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-10898713

• Understanding how fat tissue changes affect insulin sensitivity in older adults

  This study is looking at how changes in fat tissue can affect diabetes, especially in older adults, to help us understand why some people become resistant to insulin and how we can improve their health.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10885130

• How a specific enzyme in fat tissue affects insulin sensitivity

  This study is looking at how a specific enzyme called Lipin 1 affects fat tissue and insulin sensitivity, especially in people with obesity, to help find better ways to understand and treat adult-onset diabetes.

  NIH research University of Kansas Medical Center · Kansas City, United States · NIH-10883666

• How placental microRNAs affect insulin sensitivity during pregnancy

  This study is looking at how tiny molecules from the placenta might help control blood sugar and insulin levels in pregnant women, especially those at risk for gestational diabetes, to better understand their effects on both mom and baby’s health.

  NIH research Tufts Medical Center · Boston, United States · NIH-10873280

• How inflammation affects liver function and insulin sensitivity

  This study is looking at how inflammation affects non-alcoholic fatty liver disease (NAFLD) and aims to understand how certain immune factors might help us find new ways to treat this common liver condition that currently has no approved medications.

  NIH research Ut Southwestern Medical Center · Dallas, United States · NIH-10868739

• Understanding how integrins affect insulin sensitivity

  This study is looking at how a specific protein helps control insulin sensitivity and weight, with the hope of finding new ways to improve insulin function and lower the risk of heart problems for people with diabetes.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10849837

• Investigating how insulin sensitivity affects metformin's ability to slow aging

  This study is looking at whether metformin, a medication usually used for diabetes, can help people stay healthier for longer as they age, especially focusing on how insulin sensitivity might affect its benefits for those without chronic diseases.

  NIH research Oklahoma Medical Research Foundation · Oklahoma City, United States · NIH-10791774

• How estrogen affects blood vessel development in fetuses and its impact on insulin sensitivity in offspring

  This study is looking at how estrogen helps build tiny blood vessels in unborn babies, using baboons to learn more about how this process might affect insulin and sugar levels, which can be important for preventing type 2 diabetes later in life.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-10770987

• Investigating how glucocorticoid receptors affect insulin sensitivity

  This study is looking at how a specific protein called Ehmt2 affects insulin sensitivity, especially when the body is exposed to high levels of certain hormones over time, which could help us find better ways to manage insulin resistance in people with type 2 diabetes.

  NIH research University of California Berkeley · Berkeley, United States · NIH-10746410

• Investigating how cannabis affects inflammation and insulin sensitivity

  This study is looking at how using cannabis might help with inflammation and insulin sensitivity, which could be important for people with type 2 diabetes, by checking how different compounds in cannabis affect metabolism and body weight.

  NIH research University of Colorado · Boulder, UNITED STATES · NIH-10619625

• Understanding how insulin sensitivity works in muscle cells

  This study is looking at how exercise and muscle activity can help insulin work better to move sugar into muscle cells, which is important for people with diabetes, and they’re doing this by testing different ideas in the lab.

  NIH research Saint Louis University · Saint Louis, United States · NIH-10439090

• The link between workaholism and metabolic health issues like diabetes.

  This study is looking at how being a workaholic might affect your blood sugar and overall health, especially for those who are healthy or at risk for diabetes, and it aims to find out how things like stress and sleep can play a role in this.

  NIH research East Carolina University · Greenville, United States · NIH-10351452

Related topics

Quick answers

How many Insulin Sensitivity clinical trials are recruiting right now?

19, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 5 countries. The most sites are in United States (13 trials), Denmark (3 trials), Netherlands (1 trial), Germany (1 trial), Mexico (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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