Investigating mitochondrial dysfunction in women with PCOS and infertility
Polycystic Ovary Syndrome, Insulin Resistance, Infertility, Obesity, and the Associated Mitochondrial Dysfunction With These Disorders in Hungarian Patients
This study is trying to see if problems with energy production in cells are linked to polycystic ovary syndrome (PCOS) and infertility in women.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 150 (estimated) |
| Ages | 20 Years to 45 Years |
| Sex | Female |
| Sponsor | Semmelweis University Academic / other |
| Locations | 1 site (Budapest) |
| Trial ID | NCT06167135 on ClinicalTrials.gov |
What this trial studies
This observational study aims to enroll 150 women of fertile age diagnosed with polycystic ovary syndrome (PCOS), insulin resistance, infertility, or mitochondrial disease, along with an equal number of age- and sex-matched controls. The research will examine biomarkers associated with mitochondrial dysfunction and common mitochondrial DNA abnormalities. The study hypothesizes that mitochondrial dysfunction may play a significant role in the development of PCOS and insulin resistance, which are common causes of infertility. By exploring these connections, the study seeks to enhance understanding of the underlying mechanisms affecting these conditions.
Who should consider this trial
Good fit: Ideal candidates include women of reproductive age diagnosed with PCOS, insulin resistance, infertility, or mitochondrial dysfunction.
Not a fit: Patients without a diagnosis of PCOS, insulin resistance, or mitochondrial dysfunction are unlikely to benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved diagnostic and therapeutic strategies for women suffering from infertility related to PCOS and mitochondrial dysfunction.
How similar studies have performed: While the role of mitochondrial dysfunction in these conditions has been explored to some extent, this specific approach is relatively novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Presence of polycystic ovary syndrome (PCOS) or insulin resistance (IR) associated with other multisystemic phenotypes, mitochondrial dysfunction * history of infertility associated with other multisystemic phenotypes, mitochondrial dysfunction * a known history of mitochondrial dysfunction and PCOS and/or IR * general health is good and there is no serious general medical condition that would prevent participation would make participation highly risky Exclusion Criteria: * poor cooperation * refusal to participate in the study
Where this trial is running
Budapest
- Semmelweis University — Budapest, Hungary (Recruiting)
Study contacts
- Study coordinator: Vera Várhegyi, MD
- Email: varhegyi.vera@semmelweis.hu
- Phone: +36206663493
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.