Investigating mitochondrial dysfunction in women with PCOS and infertility

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to enroll 150 women of fertile age diagnosed with polycystic ovary syndrome (PCOS), insulin resistance, infertility, or mitochondrial disease, along with an equal number of age- and sex-matched controls. The research will examine biomarkers associated with mitochondrial dysfunction and common mitochondrial DNA abnormalities. The study hypothesizes that mitochondrial dysfunction may play a significant role in the development of PCOS and insulin resistance, which are common causes of infertility. By exploring these connections, the study seeks to enhance understanding of the underlying mechanisms affecting these conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Presence of polycystic ovary syndrome (PCOS) or insulin resistance (IR) associated with other multisystemic phenotypes, mitochondrial dysfunction
* history of infertility associated with other multisystemic phenotypes, mitochondrial dysfunction
* a known history of mitochondrial dysfunction and PCOS and/or IR
* general health is good and there is no serious general medical condition that would prevent participation would make participation highly risky

Exclusion Criteria:

* poor cooperation
* refusal to participate in the study

Where it's running

• Semmelweis University
  Budapest, Hungary Recruiting

Study contacts

• Study coordinator: Vera Várhegyi, MD
• Email: varhegyi.vera@semmelweis.hu
• Phone: +36206663493

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.