Comparing muscle control in trained and untrained older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to measure how the nervous system controls skeletal muscle activity in adults aged 60-85 who are either long-term resistance exercisers or untrained. Participants will undergo a series of assessments including blood tests, body composition analysis, muscle strength tests, and brain MRI scans. The study will utilize transcranial magnetic stimulation (TMS) combined with electromyography (EMG) to evaluate changes in muscle excitability. A total of 40 participants will be recruited, with equal representation from both trained and untrained groups, matched by age, sex, and BMI.

Why it matters

Who can join: the full rules

Inclusion Criteria

* Participant must have a BMI between 18.5 and 38
* Participant be aged between 60 and 85
* Regularly exercises at least 5 days a week a minimum of 30 minutes per day.
* Engages in less than 2 days of exercise less than 30 minutes each day.
* Participant must use the Mayo Clinic patient online portal.
* Participant must be able to understand English without the need of an interpreter.
* Must be willing to be contacted for research
* Participant must be willing and capable to provide consent.
* Participants shall be generally healthy as deemed acceptable by the principal investigator
* Men and women will be participant in this study. Women cannot be pregnant during this study.

Exclusion Criteria:

* Surgical History - Gastric surgery, pacemaker placement, weight loss surgery, metabolic and obstetric surgery.
* Smokers will be excluded from the study.
* Medications: Insulins, common diabetic drugs, anti-hyperglycemic drugs, beta blockers cardiac selective, beta-blockers noncardiac selective, oral steroids, opioids anti-depressants, and hormones
* Conidiations and Diagnosis: Disorder of coronary artery, hepatic failure, gastroparesis, disorder of the adrenal gland, drug related disorders, substance abuse, malignant neoplastic disease, psychotic disorders, disorder of skeletal muscle, finding of brain, chronic kidney disease, renal failure syndrome, disorder of pulmonary circulation, cerebrovascular disease, neuro developmental disorder, disorder of immune function, disorder of central nervous system.
* Participants are not to have an abnormal value as part of a lipid panel within the past 6 months.
* Participant will be excluded if they have recreational drug use or a history of alcohol abuse
* Inability or unwillingness of individual or legal guardian/representative to give written informed consent.
* Current or past participation within a specified timeframe in another clinical trial, as warranted by the administration of this intervention.
* Participant will be excluded if they have epilepsy.
* Participant will be excluded if they have cranial metal/device implants
* Participant will be excluded if they are pregnant

Where it's running

• Mayo Clinic
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: K. S. Nair, M.D., Ph.D. — Mayo Clinic
• Study coordinator: Emmett Oldham
• Email: oldham.emmett@mayo.edu
• Phone: 507-538-7772

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.