Ketone supplements and insulin sensitivity in overweight older adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

In a randomized crossover design, ten overweight but otherwise healthy adults (age 55–70, BMI 25–35) will each complete four study visits at Aarhus University Hospital and receive four different interventions in random order. Interventions are: growth hormone plus ketone supplement, growth hormone plus placebo, saline infusion plus ketone supplement, and saline plus placebo. Advanced PET/CT imaging, indirect calorimetry, and tissue biopsies will be used to measure fat breakdown, tissue glucose uptake, and whole-body energy expenditure after each intervention. The within-subject crossover design is intended to isolate the acute metabolic effects of ketone supplementation and interactions with growth hormone.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age range: 55-70 yr
* BMI: 25 - 35 kg/m2

Exclusion Criteria:

\- Any evidence of acute or chronic illnesses, apart from well-controlled hypertension, that is judged by the investigators to impact the study

Where it's running

• Aarhus University Hospital
  Aarhus N, Denmark Recruiting

Study contacts

• Study coordinator: Simon Bøggild Hansen, MD
• Email: simhan@clin.au.dk
• Phone: +45 4111 1574

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.