Condition

Polycystic Ovary Syndrome clinical trials and research

• 29Clinical trials
• 26NIH research projects
• 13Countries

Newest Polycystic Ovary Syndrome clinical trials

All recruiting trials (29)

• Precision acupuncture and lifestyle for PCOS

  This trial tests whether a precision acupuncture approach combined with a personalized lifestyle plan helps improve insulin resistance in people with PCOS compared with conventional acupuncture and standard lifestyle changes.

  Recruiting Peking University Third Hospital · Beijing, Beijing Municipality and 1 other locations · NCT07809503

• Orlistat for metabolic and hormonal features in women with PCOS

  This trial tests whether adding orlistat to lifestyle advice helps improve metabolic and hormonal aspects in women with PCOS compared to lifestyle advice alone.

  Recruiting Khyber Medical University Peshawar · Abbottābād, Khyber Pakhtunkhwa · NCT07747909

• Physical activity program for women with PCOS and fatty pancreas plus subclinical hypothyroidism

  A program of exercise is being tested to see if it helps women with PCOS who also have fatty pancreas and subclinical hypothyroidism, compared to usual care.

  Recruiting Cairo University · Giza · NCT07591246

• Glucose monitoring in women with polycystic ovary syndrome

  This project will use continuous glucose monitors to see if daily glucose patterns differ among adult women with different PCOS phenotypes.

  Recruiting Centre Hospitalier Universitaire, Amiens · Salouël · NCT07483723

• Adding regular exercise to a low‑calorie diet and metformin for women with PCOS and asthma

  This study will test whether adding regular treadmill walking to a low‑calorie diet and daily metformin helps women who have both PCOS and asthma.

  Recruiting Cairo University · Giza, Dokki · NCT07446985

• Identifying insulin-resistant PCOS with LMNA-related lipodystrophy in young women

  We’re testing whether women with a genetic insulin resistance and lipodystrophy differ from women with PCOS by age and BMI matching.

  Recruiting Assistance Publique - Hôpitaux de Paris · Paris · NCT07412028

• Combining Dlbs 3233 with clomiphene citrate for PCOS

  This will test whether adding Dlbs 3233 to clomiphene citrate helps women with PCOS improve insulin resistance (HOMA-IR), follicle maturation, and menstrual cycle regularity.

  Recruiting Early Phase 1 Inlacinpenelitian · Yogyakarta, DIY · NCT07403201

• Exercise and diet to reduce eye dryness in women with PCOS and obesity

  We will test whether adding regular treadmill walking to metformin and a low-calorie diet helps reduce eye dryness in obese women with PCOS.

  Recruiting Cairo University · Giza, Dokki · NCT07366944

• Treadmill walking plus diet for women with psoriasis and PCOS.

  This will test whether adding 40-minute treadmill walks three times a week to a low-calorie diet and daily metformin helps women who have both psoriasis and PCOS.

  Recruiting Cairo University · Giza, Dokki · NCT07289399

• Low‑dose oral contraceptives plus resistant starch for metabolic health in PCOS

  This study will test whether adding resistant starch to standard low‑dose oral contraceptives improves cardiometabolic markers and the gut microbiome in overweight women aged 18–40 with PCOS.

  Recruiting Phase 2 University of Pennsylvania · Philadelphia, Pennsylvania · NCT06852365

• Effect of a nutritional supplement on women with Polycystic Ovary Syndrome

  This study is testing whether a nutritional supplement can help women with Polycystic Ovary Syndrome feel better and improve their health.

  Recruiting Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana · Valencia, Valencia · NCT06551285

• Effects of weight loss and weight regain on androgen levels and insulin resistance in PCOS.

  This program sees if a high-protein diet with exercise and behavioral support, and different amounts of weight loss or regain, improve androgen levels and insulin resistance in women with PCOS.

  Recruiting Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT06545721

• Investigating mitochondrial dysfunction in women with PCOS and infertility

  This study is trying to see if problems with energy production in cells are linked to polycystic ovary syndrome (PCOS) and infertility in women.

  Recruiting Semmelweis University · Budapest · NCT06167135

• Using stem cells from umbilical cords to treat Polycystic Ovary Syndrome

  This study is testing whether stem cells from umbilical cords can help women with Polycystic Ovary Syndrome feel better and improve their symptoms.

  Recruiting at 2 sites Phase 1 The Foundation for Orthopaedics and Regenerative Medicine · Naples, Florida and 1 other locations · NCT06143527

• Identifying Women at Risk for Placental Dysfunction

  This study is trying to see if a new tool can help identify pregnant women at risk for placental problems by looking at their health information and blood tests.

  Recruiting Oulu University Hospital · Oulu · NCT06115122

• Lifestyle medicine program to help rural adults with multiple chronic conditions

  This program will try supervised exercise and lifestyle coaching for rural adults aged 18–64 who have two or more chronic conditions to see if access to a wellness facility improves their health.

  Recruiting West Virginia School of Osteopathic Medicine · Lewisburg, West Virginia · NCT06049420

• Understanding and treating Polycystic Ovary Syndrome

  This study is trying to gather information from women with polycystic ovary syndrome to find new ways to understand and treat their condition better.

  Recruiting Shanghai 10th People's Hospital · Shanghai, Shanghai Municipality · NCT06047574

• Investigating fasting insulin and insulin resistance across different demographics

  This study looks at how fasting insulin levels and insulin resistance vary among different groups of people based on age, sex, race, weight, and conditions like PCOS to better understand metabolic health.

  Recruiting Lilli Health · Houston, Texas · NCT05950282

• Research on Polycystic Ovary Syndrome with patient involvement

  This study is working with people who have Polycystic Ovary Syndrome (PCOS) to find out what questions matter most to them and to improve research on their experiences.

  Recruiting PCOS Challenge: The National Polycystic Ovary Syndrome Association · Bethesda, Maryland · NCT05797909

• Understanding the causes of Polycystic Ovary Syndrome

  This study is trying to understand what causes Polycystic Ovary Syndrome (PCOS) and its related problems to find new treatment options for women with PCOS and reproductive issues.

  Recruiting University of Oxford · Oxford, Oxfordshire · NCT05177562

• Using spironolactone to normalize hormone levels in pubertal girls with high androgen levels

  This study is testing if the medication spironolactone can help normalize hormone levels in pubertal girls with high androgen levels by looking at how it affects their sleep and hormone pulses.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT04723862

• Vitamin D's effect on ovulation in women with PCOS

  This study tests if taking vitamin D can help women with PCOS have more regular ovulation.

  Recruiting at 2 sites The University of Hong Kong · Hong Kong and 2 other locations · NCT04650880

• Observational study on women's menstrual health using an app

  This study is trying to learn more about women's menstrual health and related conditions by having women use an app to share their experiences.

  Recruiting Apple Inc. · Boston, Massachusetts · NCT04196595

• Improving pregnancy outcomes in women with PCOS using a new oocyte retrieval method

  This study is testing a new way to help women with PCOS get pregnant by using a special method to collect eggs and see if it improves their chances of having a baby.

  Recruiting Brown Fertility · Jacksonville, Florida · NCT04149496

• Understanding Androgen Excess and Metabolic Issues in Women with PCOS

  This study is trying to find out how to predict metabolic problems in women with PCOS by looking at their health data and grouping them based on similar traits.

  Recruiting Imperial College London · Birmingham, West Midlands · NCT03911297

• Assessing Estradiol's Effect on Hormone Secretion in Women with Polycystic Ovary Syndrome

  This study is testing how a hormone called estradiol affects other hormones in women with polycystic ovary syndrome (PCOS) to see if they respond differently than women without PCOS.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT03401047

• Investigating hormone treatment effects in girls with high androgen levels

  This study is testing if a medication called spironolactone can help girls with high androgen levels by making another hormone treatment more effective in lowering certain hormone pulses.

  Recruiting Early Phase 1 University of Virginia · Charlottesville, Virginia · NCT03068910

• Myo-inositol supplementation for women with polycystic ovarian syndrome

  This study is testing if taking Myo-inositol can help women with polycystic ovarian syndrome get pregnant more easily when combined with a fertility medication called Clomiphene Citrate.

  Recruiting Phase 3 University Hospital, Lille · Lille · NCT03059173

• Understanding Polycystic Ovary Syndrome in Women

  This study is trying to see how stress hormones, body composition, and bone health affect the quality of life for women with Polycystic Ovary Syndrome (PCOS).

  Recruiting Odense University Hospital · Odense · NCT02010814

NIH-funded research (26)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• SMAD5 and PCOS/PMOS: a new genetic clue to infertility

  A research project at Baylor College of Medicine is studying a genetic variant in SMAD5 that may cause a form of PCOS/PMOS and could lead to new ways to diagnose or treat infertility.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11595517

• TLR4 blocker for improving fertility in PCOS

  A promising, already-approved drug (disulfiram) will be tested to see if it can reduce inflammation and improve ovulation in women with PCOS.

  NIH research University of California-Irvine · Irvine, United States · NIH-11456298

• Genetic clues to PCOS: how genes shape a common women's health condition

  A doctor-scientist team at Boston Children’s Hospital is studying how genetic factors contribute to polycystic ovary syndrome (PCOS) across women, men, and children to understand the root causes.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11402645

• Semaglutide to help restore ovulation in youth and adults with PCOS

  A study tests an oral GLP-1 receptor agonist (semaglutide) to improve ovulation and hormonal balance in people with polycystic ovary syndrome (PCOS).

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11378816

• Understanding how PCOS develops during adolescence

  This grant looks at how polycystic ovary syndrome begins in teenagers and what early signs help doctors diagnose it accurately.

  NIH research Cornell University · Ithaca, United States · NIH-11378637

• AI-powered ultrasound tool to help diagnose PCOS

  A new AI-based tool uses ultrasound images to help doctors reliably identify polycystic ovary syndrome (PCOS) in reproductive-age women.

  NIH research Cornell University · Ithaca, United States · NIH-11378391

• Resistant starch to help heart and gut health in PCOS women

  A study tests whether resistant starch can improve heart and metabolic health and the gut bacteria in women with PCOS who have high androgens.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11377590

• NAFLD in PCOS: Do androgens drive liver injury and fatty liver progression?

  Young women with PCOS may face liver disease progression due to high androgen levels, and this research looks at targeted ways to slow or prevent that progression.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11345167

• Early infancy hormone patterns and PCOS risk

  This project looks at hormone levels during the first months of life in baby girls whose mothers have PCOS to find early signs that might predict later PCOS.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-11307059

• Comparing diets to lower blood sugar in polycystic ovary syndrome

  This compares different diet plans to help women with PCOS lower blood sugar, lose weight, and improve insulin-related hormone levels.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11238894

• Obesity's role in blood pressure and insulin resistance in PCOS

  This work explores how excess body fat and male hormones affect blood pressure and insulin resistance in women with PCOS.

  NIH research University of Mississippi Med Ctr · Jackson, United States · NIH-11235104

• Semaglutide to help restore monthly ovulation in teens and adults with PCOS

  This project gives semaglutide to teens and adults with polycystic ovary syndrome (PCOS) to help with weight, insulin control, and return to regular ovulation.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-11188966

• Resistant starch for polycystic ovary syndrome and heart health

  This research explores how a special type of fiber called resistant starch might help women with polycystic ovary syndrome (PCOS) improve their heart health and gut bacteria.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11177752

• Investigating brain neurons involved in polycystic ovary syndrome

  This study is looking at how certain brain cells affect hormone signals related to fertility in women with polycystic ovary syndrome (PCOS), hoping to find new ways to help improve reproductive health for those affected.

  NIH research Kent State University · Kent, United States · NIH-11172548

• Using inositol to improve reproductive and metabolic health in women with PCOS

  This study is looking at how taking inositol might help women with polycystic ovary syndrome (PCOS) by checking its effects on hormone levels and overall health over three months.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11167238

• Understanding SMAD5 Signaling in Polycystic Ovary Syndrome

  This project looks at how a specific signal, SMAD5, might be involved in Polycystic Ovary Syndrome (PCOS) to better understand its link to overall health.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11143252

• How maternal genetics of polycystic ovary syndrome affects children's health outcomes

  This study is looking at how a mother's genes related to polycystic ovary syndrome (PCOS) might affect her child's health, especially regarding birth outcomes and conditions like obesity, to help find ways to support kids who may be at risk.

  NIH research Boston Children's Hospital · Boston, United States · NIH-11119811

• How Androgens Affect Liver Health in Women with PCOS

  This project explores how elevated androgen levels in women with Polycystic Ovary Syndrome (PCOS) may lead to liver damage and the progression of fatty liver disease.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11115746

• Comparing diets to improve health in women with polycystic ovary syndrome

  This study is looking at how different diets can help women with polycystic ovary syndrome (PCOS) manage their weight and blood sugar levels, especially comparing a very low-carb diet to other options, so if you’re a woman with PCOS who is overweight or obese, this research could offer helpful insights for your health.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-10996151

• How obesity affects blood pressure and insulin resistance in women with Polycystic Ovary Syndrome

  This study is looking at how being overweight, blood pressure, and insulin levels are connected in women with Polycystic Ovary Syndrome (PCOS), and it hopes to find new ways to help manage heart health for those affected.

  NIH research University of Mississippi Med Ctr · Jackson, United States · NIH-10991667

• Investigating the role of SMAD5 signaling in Polycystic Ovary Syndrome

  This study is looking at how reproductive health and overall well-being are connected in women with Polycystic Ovary Syndrome (PCOS), focusing on how certain hormones affect both reproductive and other health issues, and it invites women with PCOS to help by sharing health information and samples.

  NIH research Baylor College of Medicine · Houston, United States · NIH-10975693

• The impact of androgens on liver health in women with Polycystic Ovary Syndrome.

  This study is looking at how high levels of certain hormones in women with PCOS might harm their liver and lead to fatty liver disease, and it hopes to find ways to help improve liver health for those affected.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-10914973

• Investigating how semaglutide can help restore ovulation in people with polycystic ovary syndrome.

  This study is looking at how the medication semaglutide can help people with polycystic ovary syndrome (PCOS) by restoring their ovulation and improving their hormone balance, especially for those who are overweight or obese.

  NIH research University of Colorado Denver · Aurora, UNITED STATES · NIH-10904665

• Understanding the genetic causes of Polycystic Ovary Syndrome

  This study is looking at the genes that might play a role in Polycystic Ovary Syndrome (PCOS) to help us understand why it happens and how it affects not just women, but also men and children, with the hope of finding better ways to address the condition beyond just treating the symptoms.

  NIH research Boston Children's Hospital · Boston, United States · NIH-10886797

• Investigating early signs of Polycystic Ovary Syndrome in young girls

  This study is looking at how Polycystic Ovary Syndrome (PCOS) might start in young girls, especially those whose moms have it, by checking hormone changes during a special time in infancy called 'mini puberty' to find early signs that could show if they might develop PCOS later on.

  NIH research Lurie Children's Hospital of Chicago · Chicago, United States · NIH-10815753

• Using inositol to improve reproductive and metabolic health in women with PCOS

  This study is looking at how taking inositol might help women with Polycystic Ovary Syndrome (PCOS) by checking if it can improve hormone levels and insulin response over three months.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-10475570

Related topics

Quick answers

How many Polycystic Ovary Syndrome clinical trials are recruiting right now?

29, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 13 countries. The most sites are in United States (10 trials), Egypt (4 trials), China (3 trials), France (3 trials), United Kingdom (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Early Phase 1: 4, Phase 1: 1, Phase 3: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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