How young adults' thigh muscles change after five days of strict bedrest

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Healthy, recreationally active adults aged 18–30 will complete baseline testing, a free-living control period, and a 5-day inpatient horizontal bedrest period with repeat testing. Measurements before and after each period include thigh muscle MRI, strength testing, mixed-meal insulin sensitivity and exogenous glucose oxidation, muscle biopsies, and blood sampling. The protocol is designed to quantify changes in muscle volume, muscle protein synthesis, mitochondrial function, and whole-body metabolic responses caused by short-term disuse. Data will compare within-subject changes from the control period to the bedrest period to isolate the effects of short-term inactivity.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Males and females 18-30 years
* BMI between 18.5-28 kg/m2
* Weight stable (within ±2kg for 6 months)
* Generally healthy as assessed by medical and physical activity questionnaires
* recreationally active

Exclusion Criteria:

* a BMI \< 18.5 and \> 28 kg/m2
* the use of insulin to control blood glucose levels
* a history of any cardiovascular, respiratory, metabolic diseases, neuromuscular or bone-wasting diseases
* the use of any medication that may affect muscle protein turnover (e.g. androgen or anabolic hormone therapy, chemotherapy)
* a (family) history of thrombosis, platelet or coagulation disorders, or antiplatelet therapy and the use of anticoagulant medications
* the presence of any unremoved, or partially removed metals underneath the skin
* a history of head or eye injury involving metal fragments
* have some type of implanted electrical device (such as a cardiac pacemaker or neurostimulator)
* have implanted metal objects as a result of surgery, such as artificial joints, aneurysm clips, metal staples
* are, or may be, pregnant
* are wearing metal braces on their teeth.

Where it's running

• Queen's Univeristy
  Kingston, Ontario, Canada Recruiting

Study contacts

• Principal investigator: Chris McGlory, PhD. — Queen's University
• Study coordinator: Chris McGlory, PhD.
• Email: chris.mcglory@queensu.ca
• Phone: 6135336000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.