Effects of lipid delivery on insulin resistance in muscle

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how the delivery of different types of lipids affects insulin resistance in muscle tissue among healthy, non-obese adults. Participants will receive either an overnight infusion of palm oil or Intralipid, with a saline control, to assess how these lipids influence fatty acid trafficking and insulin signaling. The study aims to clarify the role of intramyocellular fatty acids in muscle insulin resistance, which is a key factor in conditions like Type 2 diabetes. By measuring changes in muscle fat storage and glucose disposal rates, the research seeks to provide insights into metabolic health.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women and Men (Women premenopausal)
* BMI 18-27
* Weight stable
* Not pregnant/nursing

Exclusion Criteria:

* Ischemic heart disease
* Atherosclerotic valvular disease
* Smokers (\> 20 cigarettes per week)
* Bilateral oophorectomy
* Concomitant use of medications that can alter serum lipid profile (high dose fish oil, statins, niacin, fibrates, thiazolinediones, beta-blockers, atypical antipsychotics)
* Lidocaine allergy

Where it's running

• Mayo Clinic
  Rochester, Minnesota, United States Recruiting

Study contacts

• Principal investigator: Michael D Jensen, MD — Mayo Clinic
• Study coordinator: Pamela Reich
• Email: Reich.Pamela@mayo.edu
• Phone: 507-255-6062

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.