Timed-Restricted Eating for Improving Metabolic Health

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effects of isocaloric timed-restricted eating (TRE) on metabolic health, liver fat, brain function, inflammation, and sleep quality in individuals with obesity and insulin resistance. Participants will be assigned to either early or late TRE schedules to assess how meal timing influences their metabolic outcomes. The study aims to align eating patterns with the body's circadian rhythms to enhance metabolic flexibility and overall health. By examining these factors, the research seeks to provide insights into effective dietary interventions for obesity-related conditions.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Ability to provide informed consent;
* BMI \> 30kg/m\^2;
* Insulin resistance, as defined by fasting plasma insulin \> 62 pmol/L and/or prediabetes, as defined by fasting plasma glucose \> 5.3 and \< 7.0 mmol/L;
* Stable weight for 3 months prior to study inclusion
* For women, 1 year after last menstrual cycle

Exclusion Criteria:

* Use of any medication, except for those related to treatment of metabolic syndrome;
* Any medical condition interfering with study outcomes or design;
* History of any psychiatric disorder, including eating disorders;
* Performing shift work
* Performing intensive sports (\>3 hours/week);
* Smoking;
* Drugs abuse or alcohol abuse (\>3 units/day);
* Contraindication for MRI;
* Known lactose/gluten intolerance;
* Known soy, egg, milk or peanut allergy;
* Childhood onset of obesity

Where it's running

• Amsterdam UMC, location AMC
  Amsterdam, North Holland, Netherlands Recruiting

Study contacts

• Principal investigator: Mireille JM Serlie, MD PhD — Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
• Study coordinator: Jur Kroon, BSc
• Email: jur.kroon@amsterdamumc.nl
• Phone: +31 683238752

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.