Impact of weight loss on fat tissue signaling in muscles

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This intervention focuses on understanding how weight loss affects the molecular signaling of intermuscular adipose tissue (IMAT) in individuals with obesity. Participants will undergo a 12-week dietary intervention aimed at weight loss, with assessments including body composition, blood tests, strength testing, and thigh muscle biopsies before and after the intervention. The study aims to determine how inflammatory molecules from IMAT contribute to muscle insulin resistance and how these molecules change following weight loss. Outcomes will be compared between those who successfully lose weight and those who do not.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Generally healthy men and women aged 18-70
* BMI between 30-40
* Less than 1 hour of exercise per week
* Women:

  1. may be pre or post menopausal

Exclusion Criteria:

* Type 1 or Type 2 diabetes
* Thyroid disease
* History of lung disease
* Active use of nicotine
* Severe plasma lipid disorders
* Taking hormone replacement drugs, blood thinners, or thiazoladinediones
* Women:

  1. Currently going through menopause or peri-menopause
  2. Pregnant or breastfeeding
  3. History of Polycystic Ovary Syndrome

Where it's running

• University of Colorado Anschutz
  Aurora, Colorado, United States Recruiting

Study contacts

• Study coordinator: Bryan Bergman, PhD
• Email: bryan.bergman@cuanschutz.edu
• Phone: 3037243919

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.