Understanding How Insulin Works in Diabetes and Insulin Resistance
Official title: Alterations in Post-Receptor Insulin Signaling in Diabetes and Insulin Resistance
Funded at Joslin Diabetes Center · NIH-11127512 · Data updated 2026-11-12
This project aims to understand how insulin and similar hormones send messages inside our cells and what goes wrong in people with diabetes and insulin resistance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 17, 2021 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $592,643 |
| NIH project number | 5R01DK128429-05 |
| Project ID | NIH-11127512 on NIH RePORTER |
Who could benefit from this research
✓Could help
This foundational research is relevant to individuals living with adult-onset diabetes mellitus and those experiencing insulin resistance.
✕Less likely to help
Patients without diabetes or insulin resistance are unlikely to directly benefit from this specific research.
What this research studies
Our bodies use hormones like insulin and IGF-1 to send important signals to cells, affecting how they grow and use energy. For many years, our lab has been working to understand these internal cell messages and how they change when someone has a disease. We have learned a lot about the key steps in this process and how they can be altered in conditions like diabetes. This work helps us build a complete picture of how insulin signals work and where problems might occur, using advanced techniques to look at all the proteins involved.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of diabetes and insulin resistance, potentially paving the way for new treatments that target the root causes of these conditions.
How similar studies have gone: This project builds upon many years of successful research from the same lab, which has extensively characterized key components of insulin signaling.
Where this research is happening
-
Joslin Diabetes Center
Boston, United States Active
Researchers
- Principal investigator: Kahn, C Ronald — Joslin Diabetes Center
- Study coordinator: Kahn, C Ronald
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This study is looking at how combining different treatments can help people with type 1 diabetes lower their insulin levels and improve how their bodies respond to insulin, all while keeping an eye on heart health.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.