Understanding How Insulin Works in Diabetes and Insulin Resistance
Alterations in Post-Receptor Insulin Signaling in Diabetes and Insulin Resistance
This project aims to understand how insulin and similar hormones send messages inside our cells and what goes wrong in people with diabetes and insulin resistance.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Joslin Diabetes Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11127512 on NIH RePORTER |
What this research studies
Our bodies use hormones like insulin and IGF-1 to send important signals to cells, affecting how they grow and use energy. For many years, our lab has been working to understand these internal cell messages and how they change when someone has a disease. We have learned a lot about the key steps in this process and how they can be altered in conditions like diabetes. This work helps us build a complete picture of how insulin signals work and where problems might occur, using advanced techniques to look at all the proteins involved.
Who could benefit from this research
Good fit: This foundational research is relevant to individuals living with adult-onset diabetes mellitus and those experiencing insulin resistance.
Not a fit: Patients without diabetes or insulin resistance are unlikely to directly benefit from this specific research.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of diabetes and insulin resistance, potentially paving the way for new treatments that target the root causes of these conditions.
How similar studies have performed: This project builds upon many years of successful research from the same lab, which has extensively characterized key components of insulin signaling.
Where this research is happening
Boston, United States
- Joslin Diabetes Center — Boston, United States (Active)
Researchers
- Principal investigator: Kahn, C Ronald — Joslin Diabetes Center
- Study coordinator: Kahn, C Ronald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.